National Institutes of Health clinical trials

Listed in the registry as: U.S. National Institutes of Health.

Also known as NIH.

The registry lists 11,571 studies whose lead sponsor is National Institutes of Health or one of its 27 institutes, centers and offices the registry lists separately. 947 are recruiting or about to start. Per ClinicalTrials.gov, last updated Oct 23, 2026.

Studies

Recruiting first, then most recently updated. Showing 50 of 11,571. Browse all 11,571 →

• A Prospective Natural History Study of Lymphatic AnomaliesRecruitingNCT05731141

  Sponsor listed in the registry: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

• Microneurographic Assessment of Peripheral Nerves in Healthy Volunteers and Individuals With Sensory Dysfunction Caused by Inherited Mutations in the PIEZO2 GeneNot yet recruitingNCT06052631

  Sponsor listed in the registry: National Center for Complementary and Integrative Health (NCCIH)

• Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)Enrolling by invitationNCT06280820

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• Brain Stimulation and Vision TestingRecruitingNCT01617408

  Sponsor listed in the registry: National Institute of Mental Health (NIMH)

• Genetic Analysis of Uncommon Disease Presentations in Non-US PopulationsRecruitingNCT06595940

  Sponsor listed in the registry: National Human Genome Research Institute (NHGRI)

• Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of HealthRecruitingNCT04573062

  Sponsor listed in the registry: National Institute of Neurological Disorders and Stroke (NINDS)

• Human Experimental Models of Pain (HEMP)Not yet recruitingNCT07549490Not applicable

  Sponsor listed in the registry: National Center for Complementary and Integrative Health (NCCIH)

• NHLBI-Emory Advanced Cardiac CT ReconstructionNot yet recruitingNCT05372627

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy VolunteersRecruitingNCT06484088Early Phase 1

  Sponsor listed in the registry: National Institute of Mental Health (NIMH)

• An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Podocyte DiseasesRecruitingNCT06664814Phase 2

  Sponsor listed in the registry: National Human Genome Research Institute (NHGRI)

• Phenotype/Genotype Correlations in Movement DisordersRecruitingNCT00018889

  Sponsor listed in the registry: National Institute of Neurological Disorders and Stroke (NINDS)

• Screening ProtocolNot yet recruitingNCT07712874

  Sponsor listed in the registry: National Center for Complementary and Integrative Health (NCCIH)

• Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)RecruitingNCT02543996

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)RecruitingNCT07169630Phase 1

  Sponsor listed in the registry: National Institute of Mental Health (NIMH)

• Deciphering the Genetic Architecture of Autoimmune DiseasesRecruitingNCT06948110

  Sponsor listed in the registry: National Human Genome Research Institute (NHGRI)

• Botulinum Toxin for the Treatment of Involuntary Movement DisordersRecruitingNCT00001208

  Sponsor listed in the registry: National Institute of Neurological Disorders and Stroke (NINDS)

• Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy VolunteersNot yet recruitingNCT07504601Phase 2

  Sponsor listed in the registry: National Center for Complementary and Integrative Health (NCCIH)

• VINTAGE (Ventricular Intramyocardial Navigation for Tachycardia Ablation Guided by Electrograms) Using Commercial Off-The-Shelf (COTS) CathetersEnrolling by invitationNCT06940752Not applicable

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive PsychotherapyRecruitingNCT07640802

  Sponsor listed in the registry: National Institute of Mental Health (NIMH)

• Establishment of Biobank of Nasal Epithelium Samples From Healthy VolunteersNot yet recruitingNCT06120244

  Sponsor listed in the registry: National Institute of Allergy and Infectious Diseases (NIAID)

• Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical TrialRecruitingNCT06274749Not applicable

  Sponsor listed in the registry: National Institute on Aging (NIA)

• Development Of Neuroimaging Methods To Assess The Neurobiology Of AddictionRecruitingNCT02535702Not applicable

  Sponsor listed in the registry: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

• Natural History of Acquired and Inherited Bone Marrow Failure SyndromesRecruitingNCT05012111

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• Augmenting Parent Management Training for Child Temper Outbursts Using a Digital ToolRecruitingNCT07764536

  Sponsor listed in the registry: National Institute of Mental Health (NIMH)

• Longitudinal Natural History Protocol for PRKN- and PINK1-Linked PDNot yet recruitingNCT07613112

  Sponsor listed in the registry: National Institute of Neurological Disorders and Stroke (NINDS)

• Advancing Transplantation Outcomes in ChildrenRecruitingNCT06055608Phase 2

  Sponsor listed in the registry: National Institute of Allergy and Infectious Diseases (NIAID)

• Neuroplasticity Enhancement From Cognitive Training Reinforced by PsilocybinRecruitingNCT07721467Phase 2

  Sponsor listed in the registry: National Institute on Aging (NIA)

• Syk Inhibition in MItigating Lung Allograft Rejection (SIMILAR): A Trial to Evaluate the Safety and Tolerability of Fostamatinib in Lung Transplant Patients With Donor-Specific AntibodiesRecruitingNCT06948097Phase 1

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE4D Imaging in Healthy VolunteersRecruitingNCT07853781Phase 1

  Sponsor listed in the registry: National Institute of Mental Health (NIMH)

• Distinguishing Tics and Functional Tics Using Clinical Neurophysiological TechniquesRecruitingNCT07137442

  Sponsor listed in the registry: National Institute of Neurological Disorders and Stroke (NINDS)

• NIAID Centralized Sequencing ProtocolRecruitingNCT03206099

  Sponsor listed in the registry: National Institute of Allergy and Infectious Diseases (NIAID)

• Amyloid PET Imaging in the Baltimore Longitudinal Study of AgingRecruitingNCT07099053

  Sponsor listed in the registry: National Institute on Aging (NIA)

• EDEN Intracardiac Electrogram Recording and Classifying SystemEnrolling by invitationNCT07137455Not applicable

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• Spironolactone in Alcohol Use Disorder (SAUD)RecruitingNCT05807139Phase 1

  Sponsor listed in the registry: National Institute on Drug Abuse (NIDA)

• Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)Not yet recruitingNCT07388550Phase 1

  Sponsor listed in the registry: National Institute of Neurological Disorders and Stroke (NINDS)

• Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia AreataRecruitingNCT05398809Phase 2

  Sponsor listed in the registry: National Institute of Allergy and Infectious Diseases (NIAID)

• Plasma Lipids-Dependent Vitamin E Metabolism During Dynamic HyperlipidemiaNot yet recruitingNCT07715890Not applicable

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• SMART-r: Substance Monitoring and Active Relapse Tracking RepositoryRecruitingNCT06676059

  Sponsor listed in the registry: National Institute on Drug Abuse (NIDA)

• Dynamic Magnetic Resonance Imaging of Human Subarachnoid Space Using Intrathecal Gadolinium ContrastNot yet recruitingNCT07796360Phase 1

  Sponsor listed in the registry: National Institute of Neurological Disorders and Stroke (NINDS)

• Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Refractory to Covalent Bruton Tyrosine Kinase Inhibitor or Pirtobrutinib and Previously Treated With a BCL2 InhibitorNot yet recruitingNCT07796373Phase 2

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)Not yet recruitingNCT06868914Phase 1

  Sponsor listed in the registry: National Institute on Drug Abuse (NIDA)

• NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label DevicesNot yet recruitingNCT07806149Not applicable

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• Environment and Alcohol: A Pilot StudyRecruitingNCT06860607Phase 1

  Sponsor listed in the registry: National Institute on Drug Abuse (NIDA)

• Treatment of Antibody-Mediated Rejection (ABMR) With CarBelRecruitingNCT06918990Phase 1

  Sponsor listed in the registry: National Institute of Allergy and Infectious Diseases (NIAID)

• Epcoritamab as Consolidative Therapy for Waldenstr(SqrRoot)(Delta)m Macroglobulinemia (WM) Treated With a Bruton Tyrosine Kinase Inhibitor (BTKi)Not yet recruitingNCT07882173Phase 2

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• Developing Transcranial Neuromodulation Protocols for Learning and Decision-MakingRecruitingNCT06561828Early Phase 1

  Sponsor listed in the registry: National Institute on Drug Abuse (NIDA)

• Evaluating the Dose, Safety, Tolerability, and Immunogenicity of Mosaic Hexavalent Influenza Vaccine VRCFLUMOS0116-00-VP (FluMos-v2) With and Without ALFQ Adjuvant in Healthy AdultsRecruitingNCT06863142Phase 1

  Sponsor listed in the registry: National Institute of Allergy and Infectious Diseases (NIAID)

• Metabolic Impact of VLCPUFA-Rich Fish Oil: A Clinical Study on Omega-3 Index Enhancement in Healthy IndividualsRecruitingNCT07882160Not applicable

  Sponsor listed in the registry: National Heart, Lung, and Blood Institute (NHLBI)

• Modeling Host-Pathogen Interaction Using Lymphoid OrganoidsRecruitingNCT06479837

  Sponsor listed in the registry: National Institute of Allergy and Infectious Diseases (NIAID)

• A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and ToxicityRecruitingNCT06406465Phase 2

  Sponsor listed in the registry: National Cancer Institute (NCI)