National Institutes of Health: Depressive Disorder trials

The registry lists 86 Depressive Disorder studies with National Institutes of Health as lead sponsor. 2 are open to participants now and 14 have results posted.

Phase 1 10Phase 2 23Phase 3 6Phase 4 7No phase 42(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionRecruitingNCT06511908Phase 2
• Natural History of Depression, Bipolar Disorder and Suicide RiskRecruitingNCT06462196
• Antidepressant Effects of TS-161 in Treatment-Resistant DepressionTerminatedNCT04821271Phase 2Results posted
• Phase 1 Evaluation of (2R,6R)-HydroxynorketamineCompletedNCT04711005Phase 1Results posted
• Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive DisorderCompletedNCT02484456Phase 2Results posted
• Does Enhanced Glutamate Transporter Function Produce Antidepressant Effects in People With Major Depression?TerminatedNCT02049385Phase 1/2Results posted
• Combining Medications to Enhance Depression OutcomesCompletedNCT00590863Phase 4Results posted
• Antidepressant Effects of NR2B in Major DepressionCompletedNCT00472576Phase 1Results posted
• The Antidepressant Efficacy of the Anticholinergic ScopolamineTerminatedNCT00369915Phase 2Results posted
• Org 24448 to Treat Major DepressionTerminatedNCT00113022Phase 2Results posted
• Rapid Antidepressant Effects of Ketamine in Major DepressionCompletedNCT00088699Phase 1/2Results posted
• Lexapro and Pramipexole and to Treat Major DepressionCompletedNCT00086307Phase 2Results posted
• Rapid Antidepressant Effects of Yohimbine in Major DepressionCompletedNCT00078715Phase 2Results posted
• Electroacupuncture for Major DepressionCompletedNCT00071110Phase 2Results posted
• Clinical Trial of Estrogen for Postpartum DepressionTerminatedNCT00059228Phase 2Results posted
• Raloxifene and Rimostil for Perimenopause-Related DepressionCompletedNCT00030147Phase 4Results posted
• Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)WithdrawnNCT03895658Phase 1
• PET Imaging of Brain mGluR1 Receptors Using [18F]FIMXCompletedNCT02230592
• An Investigation of the Biological and Neuronal Mechanisms of Post Traumatic Stress Disorder, Depression and Post-Concussive Syndrome Onset Following a Traumatic Brain InjuryCompletedNCT02019654
• Brain Inflammation in Major Depressive Disorder BackgroundCompletedNCT01851356
• Brain Imaging, Genetics and Treatment for Major DepressionWithdrawnNCT01568684Phase 1
• A Prospective Study of Postpartum Depression in Women With Major DepressionTerminatedNCT01328613
• Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive DisorderWithdrawnNCT01313403Not applicable
• PET Whole Body Distribution Studies Using [11C]CUMICompletedNCT01132872
• Depression Outcomes Study of ExerciseCompletedNCT00964054Phase 1
• GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major DepressionCompletedNCT00931619
• p11 Protein Levels in Patients With Major Depressive Disorder Treated With CitalopramCompletedNCT00697268
• Cognitive Behavioral Treatment of Depression in ESRD Patients on DialysisCompletedNCT00618475Not applicable
• Improving Depression Treatment for Older Minority AdultsCompletedNCT00570427Not applicable
• Assessing Treatment Emergent Suicidal Ideation in Patients With Major DepressionCompletedNCT00532103
• Brain Activity Changes and Treatment Response in Depressed People Who Are Receiving Antidepressant MedicationCompletedNCT00375843Phase 4
• Preventing Depression Recurrence in DiabetesCompletedNCT00374426Phase 4
• Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed PatientsCompletedNCT00369798Phase 1
• Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research GroupCompletedNCT00265291Phase 2
• Epidemiology of Depression and Heart Failure in AgingCompletedNCT00241761
• Integrated Treatment for Cocaine and Mood Disorders - 1CompletedNCT00227812Phase 2
• Preventing Depression in Methadone Maintenance Patients Receiving Hepatitis C Treatment - 1CompletedNCT00218556Not applicable
• Parent Psychoeducation and Cognitive Behavior Therapy for Latino Adolescents With DepressionStatus unknownNCT00118469Phase 2
• Dopamine Receptor Imaging in Mood DisordersCompletedNCT00116077
• Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood DisordersCompletedNCT00097175
• Ethyl Eicosapentanoic Acid (Ethyl-EPA) for Treating Major DepressionCompletedNCT00096798Phase 3
• Yoga for Treating People at Risk for Diabetes or With Both HIV and DepressionCompletedNCT00090506Phase 1
• Neurocardiac Control in Major DepressionCompletedNCT00084162
• Function of Catecholamines in the Brain During DepressionCompletedNCT00082030
• FMRI Study of Performance During a Probabilistic Reversal Learning Task in DepressionCompletedNCT00075296
• Evaluating Brain Responses to Facial Expressions in Major Depressive DisorderCompletedNCT00071123
• An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant DepressionCompletedNCT00070694Phase 2
• PUFA Augmentation in Treatment of Major DepressionCompletedNCT00067301Phase 3
• The Effects of Estrogen Withdrawal on Mood Symptoms in WomenCompletedNCT00060736
• Brain Regulation of Emotions in People With Depression and AnhedoniaCompletedNCT00059579
• Screening Evaluation for Women With Postpartum DepressionTerminatedNCT00056901
• Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging StudiesTerminatedNCT00055575Phase 2
• Brain Imaging in DepressionCompletedNCT00050700
• MRI Study of Brain Activity and Risk for Depression in AdolescentsCompletedNCT00047944
• Examination of a Soy-Based Supplement for Major DepressionCompletedNCT00042380Phase 2
• Clinical Trial of Memantine for Major DepressionCompletedNCT00040261Phase 3
• Major Depression and Inflammatory Risk Markers for Coronary Heart DiseaseCompletedNCT00037505
• Clinical Trial of Felbamate for Treatment-Resistant Bipolar DepressionCompletedNCT00034229Phase 2
• Treatment of Depression With Massage in HIVCompletedNCT00033852Phase 2
• Serotonin Function During DepressionCompletedNCT00033787
• The Treatment of Children and Adolescents With Treatment-Resistant DepressionCompletedNCT00029640
• Magnetic Stimulation for Parkinson DiseaseCompletedNCT00029276Phase 1
• Qigong Therapy For Heart Device PatientsCompletedNCT00027001Not applicable
• Riluzole to Treat Major DepressionCompletedNCT00026052Phase 2
• Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress DisorderCompletedNCT00025974
• Brain Function in Mentally Ill AdolescentsCompletedNCT00025857
• Sequenced Treatment Alternatives to Relieve Depression (STAR*D)CompletedNCT00021528Phase 4
• Acupuncture in the Treatment of DepressionCompletedNCT00010517Phase 3
• Treatment for Adolescents With Depression Study (TADS)CompletedNCT00006286Phase 3
• Bone Loss in Premenopausal Women With DepressionCompletedNCT00006180Phase 4
• Depression In Juvenile DiabeticsCompletedNCT00005116Not applicable
• Treatment of Depression in Youth With Bipolar DisordersTerminatedNCT00005015Phase 3
• Treatment of Major Depression With St. John's Wort (Hypericum)CompletedNCT00005013Not applicable
• Heart Disease Risk Factors in Major DepressionCompletedNCT00001969
• Use of Bone Biopsy to Better Understand the Causes of Decreased Bone Mineral Density in DepressionCompletedNCT00001916
• Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety)CompletedNCT00001770
• Consequences of Conjugal Bereavement in AdultsCompletedNCT00001659
• Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood DisordersCompletedNCT00001545Phase 2
• Treatment of Mid-Life-Related Mood DisordersCompletedNCT00001487Phase 2
• Acute Effectiveness of Additional Drugs to the Standard Treatment of DepressionCompletedNCT00001483Phase 2
• Psychosocial Correlates and Coping Strategies Associated With Long-Term Survival of HIV-Infected ChildrenCompletedNCT00001435
• Glucocorticoid Effects on Cellular Cytokine ReleaseCompletedNCT00001415
• Bone Mineral Density in Women With Major DepressionCompletedNCT00001413
• Effects of Sex Hormones on Circadian Rhythm in Men and WomenCompletedNCT00001285
• The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related DisordersCompletedNCT00001232
• Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major Depressive DisorderCompletedNCT00000375Phase 4