National Institutes of Health: Cocaine-Related Disorders trials

The registry lists 106 Cocaine-Related Disorders studies with National Institutes of Health as lead sponsor. 0 are open to participants now and 3 have results posted.

Early Phase 1 1Phase 1 40Phase 2 46Phase 3 2Phase 4 4No phase 13(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Lorcaserin in the Treatment of Cocaine Use DisorderCompletedNCT03007394Phase 2Results posted
• Theta-Burst Stimulation as a Treatment for Reducing Cocaine UseTerminatedNCT02927236Not applicableResults posted
• A Multi-Center Trial of Nepicastat for Cocaine DependenceCompletedNCT01704196Phase 2Results posted
• Study to Assess Potential Interactions Between Intravenous Cocaine and Oral LorcaserinCompletedNCT02393599Phase 1
• Dopamine Rhythms in Health and AddictionWithdrawnNCT02233829Early Phase 1
• Interactions Between Intravenous (IV) Cocaine and LofexidineTerminatedNCT01148992Phase 1
• Measuring Distress Tolerance With Functional MRICompletedNCT01038232
• PET Assays of Striatal Dopamine Marker in Cocaine CravingCompletedNCT01036516
• Reward Processing in Cocaine AddictionCompletedNCT01036074
• Risk Perception in Drug-Dependent Adults With and Without SchizophreniaCompletedNCT01031563
• Brain Glutamate Receptors and Cocaine DependenceTerminatedNCT00951314
• Psychology of Reward and Punishment: Functional and Molecular Brain Imaging and Monoaminergic CorrelatesWithdrawnNCT00865332
• Aripiprazole for Prevention of Relapse to Cocaine Use in Methadone-Maintenance PatientsCompletedNCT00780702Phase 1
• Buprenorphine Naltrexone-P1 A-CocaineCompletedNCT00733720Phase 1
• Effects of Propranolol on Responses to Drug-Related Imagery ScriptsTerminatedNCT00688805Phase 1
• Vigabatrin Ph 1 Cocaine Interaction StudyCompletedNCT00626834Phase 1
• Metabolic Effects of CocaineCompletedNCT00451230Not applicable
• Effect of Clonidine on Responses to Imagery ScriptsCompletedNCT00318760Phase 1
• Serotonin, Impulsivity, and Cocaine Dependence TreatmentCompletedNCT00297505Phase 2
• Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility StudyCompletedNCT00292136
• Combined Behavioral and Pharmacologic Treatment of Polydrug AbuseCompletedNCT00292123Phase 1
• Treatment of Heroin and Cocaine With Methadone Maintenance and Contingency ManagementCompletedNCT00292110Phase 1
• Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine - 1CompletedNCT00265265Phase 1
• Integrated Treatment for Cocaine and Mood Disorders - 1CompletedNCT00227812Phase 2
• Effectiveness of GABA Agonists in Reducing the Reinforcing Effects of CocaineCompletedNCT00218166Phase 2
• Interaction Between Vanoxerine (GBR 12909) and Cocaine in Cocaine Dependent IndividualsTerminatedNCT00218049Phase 1
• The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1CompletedNCT00158288Phase 2
• Fluoxetine to Reduce Cocaine Use in Cocaine and Opioid AddictsCompletedNCT00142779Not applicable
• Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1CompletedNCT00136825Phase 1
• Effectiveness of Tiagabine for Cocaine Dependence in Methadone-Maintained Individuals - 1CompletedNCT00129298Phase 2
• Cocaethylene as a Treatment for Cocaine Dependence - 1CompletedNCT00124696Phase 1
• Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1Status unknownNCT00100113Phase 1
• Modafinil for the Treatment of Cocaine Dependence - 1CompletedNCT00100100Phase 2
• Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1Status unknownNCT00094315Phase 1
• Interactions Between Cocaine and Ethanol and Disulfiram - 1Status unknownNCT00094289Phase 1
• GBR 12909 Study in Cocaine Experienced African American Volunteers - 1Status unknownNCT00089687Phase 1
• Interaction Between Cocaine and Quetiapine - 1Status unknownNCT00087750Phase 1
• Tiagabine for the Treatment of Cocaine Dependence - 1CompletedNCT00086255Phase 2
• Baclofen for the Treatment of Cocaine Dependence - 1CompletedNCT00082485Phase 2
• Assessment of Potential Interactions Between Cocaine and RPR 102681 - 1CompletedNCT00067535Phase 1
• Assessment of the Potential Interactions Between Cocaine and GBR 12909 - 1Status unknownNCT00051896Phase 1
• Development of Human Laboratory Study Model of Cocaine Relapse Prevention. - 1Status unknownNCT00040066Phase 1
• A Study of Cabergoline for the Treatment of Cocaine Dependence - 1CompletedNCT00033111Phase 2
• Cocaine-Metyrapone Interaction Study - 1Status unknownNCT00033098Phase 1
• Ondansetron for the Treatment of Cocaine Dependence - 1CompletedNCT00033085Phase 2
• Assessment of Potential Interactions Between Cocaine and Tolcapone - 1Status unknownNCT00033059Phase 1
• Evaluation of Modafinil as a Cocaine Treatment Medication and Interactions With Cocaine - 1Status unknownNCT00033046Phase 1
• Reserpine for the Treatment of Cocaine Dependence - 1CompletedNCT00033033Phase 2
• Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1CompletedNCT00032929Phase 3
• Drug Interaction Study With NS2359 and Cocaine in Cocaine Experienced Volunteers - 1Status unknownNCT00032916Phase 1
• Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11CompletedNCT00015301Phase 4
• Pathophysiological Subtyping of Abnormalities in Cocaine Dependence - 9CompletedNCT00015275Phase 4
• Prepulse Inhibition of Startle in Cocaine Dependence - 7CompletedNCT00015249Phase 1
• Modeling Impaired Judgement in Cocaine Abusers - 6CompletedNCT00015236Phase 4
• Methylphenidate in the Treatment of Cocaine Dependent Patients With Adult Attention Deficit Hyperactivity Disorder - 5CompletedNCT00015223Phase 2
• Tiagabine, Sertraline, or Donepezil for the Treatment of Cocaine Dependence - 9CompletedNCT00015132Phase 2
• Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7CompletedNCT00015106Phase 2
• Naltrexone in Treatment of Cocaine Dependence - 5CompletedNCT00015080Phase 2
• Cocaine-Methylphendidate Interaction Study - 4CompletedNCT00015067Phase 1
• Methylphendidate Treatment of Cocaine Dependent Patients With Attention Deficit Hyperactivity Disorder - 3CompletedNCT00015054Phase 2
• Infusion Laboratory: Protocol 5 (Flupenthixol) - 14Status unknownNCT00000349Phase 1
• Infusion Laboratory: Protocol 4 (Dihydrexidine) - 13Status unknownNCT00000348Phase 1
• Risperidone for Treatment of Cocaine Dependence in Outpatients - 12CompletedNCT00000347Phase 2
• Risperidone for the Treatment of Cocaine Dependence - 7CompletedNCT00000342Phase 2
• Pemoline in the Treatment of Stimulant Dependence - 5WithdrawnNCT00000340Phase 2
• Infusion Laboratory: Protocol 3 (Risperidone) - 4Status unknownNCT00000339Phase 1
• Infusion Laboratory: Protocol 2 (Lisuride) - 3Status unknownNCT00000338Phase 1
• Infusion Laboratory: Protocol 1 - Selegeline - 2CompletedNCT00000337Phase 1
• Selegiline in Outpatient Treatment for Cocaine Dependence - 1CompletedNCT00000336Phase 2
• Evaluation of Benztropine for Cocaine Craving - 2CompletedNCT00000333Phase 2
• High Dose Nimodipine Treatment Adjunct - 1CompletedNCT00000332Phase 2
• Psychostimulant Abuse - Novel Treatment Approaches - 1CompletedNCT00000325Phase 1
• Tryptophan and Behavior Therapy for Cocaine Abuse - 1CompletedNCT00000324Phase 2
• Therapeutic Potential of Kappa-Opioids Against Cocaine - 1CompletedNCT00000323
• Human Dopamine Transported Imaging in Cocaine Abuse: 2 - 2CompletedNCT00000316Phase 1
• Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1CompletedNCT00000315Phase 1
• M-CPP and Fenfluramine in Cocaine Addicts - 3CompletedNCT00000314Phase 2
• Predictive Values of Serotonergic Alterations for Outcome - 2TerminatedNCT00000313Phase 1
• Alterations in Serotonergic Functions in Cocaine Addicts - 1CompletedNCT00000312Phase 1
• Serotonin/Dopamine Antagonism of Cocaine Effect: 2 - 2TerminatedNCT00000310Phase 2
• Dextroamphetamine-Cocaine Behavioral Intervention - 5CompletedNCT00000308Phase 2
• Naltrexone as Adjunct in Alcoholic Cocaine Dependent Patients - 4CompletedNCT00000307Phase 2
• Dextroamphetamine as Adjunct in Cocaine/Opiate Dependent Patients - 3CompletedNCT00000306Phase 2
• Dextroamphetamine as an Adjunct in Cocaine Treatment - 1CompletedNCT00000304Phase 2
• Effects of Carvedilol on Cocaine Use in Humans - 11CompletedNCT00000294Phase 2
• Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10CompletedNCT00000293Phase 3
• Acute Withdrawal From Smoked Cocaine - 9CompletedNCT00000292Phase 1
• Effects of Labetalol on Human Cocaine Use - 8CompletedNCT00000291Phase 2
• Stress Hormones and Human Cocaine Use - 7CompletedNCT00000290Phase 1
• Relapse Patterns in Female Cocaine Users - 4CompletedNCT00000287
• Effects of Nefazodone on Treatment of Female Cocaine Abusers - 3CompletedNCT00000286Phase 2
• Effects of Phenytoin on Cocaine Use in Humans - 2CompletedNCT00000285Phase 1
• Cocaine Abuse and ADHD - 10CompletedNCT00000275Phase 2
• Flupenthixol and Haloperidol for Treating Cocaine Abuse Schizophrenics - 9CompletedNCT00000274Phase 2
• Pergolide Treatment for Substance Abusers - 4CompletedNCT00000269Phase 2
• Cocaine Abuse and Attention Deficit Disorder - 3CompletedNCT00000268Not applicable
• Risperidone Treatment in Dually-Diagnosed Individuals - 2CompletedNCT00000267Phase 2
• Flupenthixol Treatment in Schizophrenic Cocaine Abusers - 1CompletedNCT00000266Phase 2
• Evaluation of a Desipramine Ceiling in Cocaine Abuse - 1CompletedNCT00000245Phase 2
• Pharmacotherapy and Intensive Treatment - 2CompletedNCT00000218Phase 4