National Institutes of Health: Cardiovascular Diseases trials

The registry lists 534 Cardiovascular Diseases studies with National Institutes of Health as lead sponsor. 13 are open to participants now and 10 have results posted.

Phase 1 6Phase 2 33Phase 3 70Phase 4 3No phase 423(a study in two phases counts in both)

Studies

Page 1 of 6. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT ImagingRecruitingNCT07613099Phase 3
• Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort StudyRecruitingNCT06730113
• Thrombosis and Inflammation in Vessels Initiative (TIVI)RecruitingNCT06552767
• The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVDRecruitingNCT05440422Phase 2
• Natural History Study of CADASILRecruitingNCT05072483
• Technical Development of Cardiovascular Magnetic Resonance ImagingRecruitingNCT04927429
• Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy VolunteersRecruitingNCT04216342Phase 1
• Clinical and Molecular Characteristics of Primary Aldosteronism in BlacksRecruitingNCT03374215
• Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)RecruitingNCT02543996
• Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss InterventionRecruitingNCT01927783
• New Heart Imaging Techniques to Evaluate Possible Heart DiseaseRecruitingNCT01399385Not applicable
• Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora PopulationsEnrolling by invitationNCT01316783
• Diabetes and Heart Disease Risk in BlacksRecruitingNCT00001853
• Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African Americans Study (GENE-FORECAST): Sodium Intervention Trial (SIT)CompletedNCT04717336Not applicableResults posted
• Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study)CompletedNCT04216589Phase 2Results posted
• CT COMPARE: CT Coronary Angiography to Measure Plaque ReductionTerminatedNCT02740699Phase 4Results posted
• Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected AdultsCompletedNCT02344290Phase 3Results posted
• Effects of Niacin Therapy on Lipoprotein Composition and FunctionCompletedNCT02322203Not applicableResults posted
• Evaluation of Oral Alpha-Cyclodextrin for Decreasing Serum CholesterolCompletedNCT01131299Phase 2Results posted
• Myocardial Function & FFA Metabolism in HIV Metabolic SyndromeCompletedNCT00656851Not applicableResults posted
• Exercise and Pioglitazone for HIV-Metabolic SyndromesCompletedNCT00639457Not applicableResults posted
• Folic Acid for Vascular Outcome Reduction In Transplantation (FAVORIT)CompletedNCT00064753Phase 2/3Results posted
• Action to Control Cardiovascular Risk in Diabetes (ACCORD)CompletedNCT00000620Phase 3Results posted
• Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST): Prospective COVID-19 Natural History StudyCompletedNCT05484882
• People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral AgentsActive, not recruitingNCT03520660Phase 4
• Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in AdultsCompletedNCT03372733Phase 2
• Extracellular RNAs in Relation to Cardiometabolic RiskCompletedNCT03225196
• RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2CompletedNCT03225183
• Impact of Elastin Mediated Vascular Stiffness on End OrgansCompletedNCT02840448
• CADASIL Disease DiscoveryCompletedNCT02821780
• Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue BankCompletedNCT02706639
• WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)CompletedNCT02692846
• Effects of Tart Cherry and Aroniaberry Supplementation on Endothelial Function and Cardiovascular Measures in Healthy Older Adults: Interactions With Genotype and ProteomeWithdrawnNCT02379403
• Effect of Fasting on the NLRP3 InflammasomeCompletedNCT02122575
• Hispanic Community Health Study / Study of LatinosActive, not recruitingNCT02060344
• Study of the Effects of Blackcurrant Extract and Omega-3 Fats on the Health of the Heart and Blood VesselsWithdrawnNCT02019680
• Links Between Inflammation and Cardiometabolic DiseasesCompletedNCT01934660
• The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI)CompletedNCT01778569
• Developing the Family Map: Looking at Communal CopingCompletedNCT01633021
• Blood Vessel StudyCompletedNCT01524549
• Simplified Cardiovascular Management StudyCompletedNCT01503814Not applicable
• Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS)Active, not recruitingNCT01323322
• Gulf Long-Term Follow-Up StudyActive, not recruitingNCT01287000
• The Perceived Impact of Children s Risk Status for Hypertrophic Cardiomyopathy on Families: an Exploratory StudyCompletedNCT01160536
• Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of PathophysiologyCompletedNCT01089114
• Human Atherosclerotic Plaque Inflammation Imaged Using PDG-PET/CTCompletedNCT00958815
• Improving Neurologic Outcomes in People With Diabetes Who Are Undergoing Heart SurgeryCompletedNCT00836329Phase 3
• Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected AdultsCompletedNCT00776412
• A Web-Based Cardiovascular Intervention for the WorkplaceStatus unknownNCT00763308Phase 1
• Effect of a PPAR-Alpha Agonist on the Age Related Changes in Myocardial Metabolism and Mechanical FunctionStatus unknownNCT00627653Not applicable
• Using Differences in Peripheral Blood Leukocyte Gene Expression to Determine Cardiovascular Disease RiskCompletedNCT00613158
• Association Between Abdominal Body Composition, Inflammation, and Risk for Cardiovascular Disease (The MESA ABD Study)CompletedNCT00612365
• Evaluating Electrocardiogram (ECG) Abnormalities From Young Adulthood Through Middle AgeCompletedNCT00556751
• Effectiveness of an Anger and Stress Management Program on Reducing Blood Pressure Levels in YouthCompletedNCT00508612Phase 2
• Effect of Diet on Vascular Disease in Pre-Menopausal WomenCompletedNCT00484861
• Cardiovascular Disease ScreeningTerminatedNCT00483951
• Reduction of Smoking in Cardiac Disease PatientsCompletedNCT00469885Phase 2
• Risk Communication Within Mexican-American FamiliesCompletedNCT00469339
• Factors Associated With Coronary Heart Disease in African Americans in the Jackson Heart StudyCompletedNCT00415415
• Catheter-Based Treatment of Cardiovascular DiseaseCompletedNCT00380016Not applicable
• Lifetime Risk for Cardiovascular Disease Among Non-White Ethnic GroupsCompletedNCT00377702
• Effect of Aerobic Exercise on Blood Pressure ChangesCompletedNCT00358137Not applicable
• Genetic Susceptibility to Cardiovascular Disease in Patients on Kidney DialysisCompletedNCT00340119
• Genetic Predictors of Cardiovascular DiseaseCompletedNCT00339599
• Prospective Studies of the Natural History of Diabetes Mellitus and Its Complications in the Gila River Indian CommunityCompletedNCT00339482
• Effects of Age and Exercise on Blood Pressure RegulationStatus unknownNCT00319397
• School-Based Intervention to Increase Physical Activity Among Adolescent FemalesCompletedNCT00296101Not applicable
• Conditioned Placebo Effects and Treatment of HypertensionCompletedNCT00269269Phase 2
• Stepped Intervention for Meds Adherence and Blood Pressure ControlCompletedNCT00257101Not applicable
• Calcium Channel Splice Variant Expression in Cardiovascular Disease and AgingCompletedNCT00251615
• Vascular Aging: The Link That Bridges Age to Atherosclerosis (The VALIDATE Study)TerminatedNCT00246493
• Acipimox to Improve Hyperlipidemia and Insulin Sensitivity Associated With HIVCompletedNCT00246402Not applicable
• Preschool Based Obesity Prevention Effectiveness TrialCompletedNCT00241878Not applicable
• Epidemiology of Depression and Heart Failure in AgingCompletedNCT00241761
• Guideline Adherence for Heart HealthCompletedNCT00224848Phase 2
• Peripheral Effects of Exercise on Cardiovascular Health (STRRIDE I)CompletedNCT00200993Phase 2
• Adherence to Weight Loss for Hypertension in African American WomenCompletedNCT00142649Not applicable
• Tailored Videos to Reduce Tobacco Smoke Exposure Among Pregnant Women and NewbornsStatus unknownNCT00142623Not applicable
• Effects of Exercise Training on Diastolic Heart Function in Postmenopausal WomenCompletedNCT00125476Not applicable
• Estrogen Replacement to Reduce Risk of Neurologic Injury After Coronary Artery Bypass Graft SurgeryTerminatedNCT00123539Not applicable
• Patient-Physician Partnership to Improve High Blood Pressure AdherenceCompletedNCT00123045Phase 4
• Work, Weight, and Wellness Program: The 3W ProgramCompletedNCT00123019Not applicable
• Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs)CompletedNCT00119834
• Fluoxetine as a Quit Smoking AID for Depression ProneCompletedNCT00113737Not applicable
• Promoting Smoking Cessation and Reducing Weight GainCompletedNCT00113711Not applicable
• Effect of Exercise on Elevated C-reactive Protein Concentrations in Formerly Inactive AdultsCompletedNCT00113061Not applicable
• 20 Year Changes in Fitness & Cardiovascular Disease Risk - Ancillary to CARDIACompletedNCT00106457
• Hypertension Education and Treatment Partnership for Reducing Ethnic Differences in the Risk of Cardiovascular DiseaseCompletedNCT00101504
• STORIES-Stories to Communicate Risk About TobaccoCompletedNCT00101491Not applicable
• CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of EnergyCompletedNCT00099151Not applicable
• MRI-Guided Balloon Angioplasty to Treat Blood Flow Blockage in the LegsCompletedNCT00094783Phase 1
• Long-Term Predictors of Morbidity in Older AgeCompletedNCT00094263
• HEARTS: Heart, Exercise, and Resistance Training StudyWithdrawnNCT00094250Not applicable
• Pharmacogenetics and Cardiovascular EventsCompletedNCT00094198
• Genetics and Cardiovascular Reactivity in Young TwinsCompletedNCT00083850
• Gene-Specific Responses to Exercise in Discordant TwinsCompletedNCT00083837
• HYPGENE-Genetics Fitness Obesity & Risk of HypertensionCompletedNCT00083811
• Estrogen Receptor Variants, HDL, and AtherosclerosisCompletedNCT00081705
• Logical Analysis of Data and Cardiac Surgery RiskCompletedNCT00081666
• Gender, Obesity, C-Reactive Protein, and Oxidative StressCompletedNCT00079963Not applicable