National Institutes of Health: Epilepsy trials

The registry lists 47 Epilepsy studies with National Institutes of Health as lead sponsor. 8 are open to participants now and 3 have results posted.

Early Phase 1 1Phase 1 2Phase 2 7Phase 3 1Phase 4 1No phase 35(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• MEHMO Natural History and BiomarkersRecruitingNCT06019182
• Study of Direct Brain Recording and Stimulation for Memory EnhancementEnrolling by invitationNCT04095026
• Investigating Epilepsy: Screening and EvaluationRecruitingNCT03478852
• Tumor Related EpilepsyRecruitingNCT02639325
• Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant EpilepsyRecruitingNCT02531880Phase 1
• Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging DatabaseRecruitingNCT02107989
• Surgery as a Treatment for Medically Intractable EpilepsyRecruitingNCT01273129
• Evaluation and Treatment of Neurosurgical DisordersRecruitingNCT00060541
• Buspirone Therapy for Localized EpilepsyTerminatedNCT01496612Phase 2Results posted
• PRX-00023 Therapy in Localization-Related EpilepsyTerminatedNCT01281956Phase 2Results posted
• Double Blind, Crossover Study of Fish Oil [EPA and DHA] for Intractable Partial SeizuresCompletedNCT00871377Phase 2Results posted
• Exercise Education for Adults With Seizure DisordersCompletedNCT01856335Early Phase 1
• Study of [11C]DPA-713 for Temporal Lobe EpilepsyCompletedNCT01793532
• Brain P-gp and Inflammation in People With EpilepsyCompletedNCT01663545
• Connectivity Analysis for Investigation of Auditory Impairment in EpilepsyTerminatedNCT01212068
• GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major DepressionCompletedNCT00931619
• Magnetoencephalography in Absence SeizuresCompletedNCT00884351
• Language Mapping in Patients With EpilepsyCompletedNCT00706160
• Relationship of HHV-6B Virus to Seizures and Brain InjuryTerminatedNCT00597285
• The Role of Serotonin in SeizuresTerminatedNCT00439387
• Electrical Brain Stimulation to Reduce Epileptic SeizuresCompletedNCT00344877
• Herpes Virus-6 and EpilepsyCompletedNCT00085683
• Language and Emotional Function in Patients With Temporal Lobe EpilepsyCompletedNCT00081432
• MRI in Autosomal Dominant Partial Epilepsy With Auditory FeaturesCompletedNCT00072813
• Activating Effects of Sleep Deprivation on Synchronized MEG-EEG Recordings of Epilepsy Patients With Non-Diagnostic EEGCompletedNCT00071370
• Non-Invasive Seizure Localization in Patients With Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG RecordingsCompletedNCT00071305
• Reducing Seizure Frequency Using Cooling of the Head and NeckCompletedNCT00067210Phase 2
• Transcranial Magnetic Stimulation to Treat EpilepsyCompletedNCT00048490Phase 2
• Role of Hormones in Susceptibility to Seizures in Women With EpilepsyCompletedNCT00044252
• Functional Coupling of Cortico-Cortical and Cortico-Muscular Connections During Motor Movements: An Electrocorticographic Study of Ipsilateral Motor ControlCompletedNCT00036595
• Hormone Replacement in Menopausal Women With EpilepsyCompletedNCT00027209Phase 2
• Study of Specimens Obtained During Epilepsy SurgeryCompletedNCT00025714
• Evaluation and Treatment of Patients With EpilepsyTerminatedNCT00013845
• Genetic Study of Familial EpilepsyCompletedNCT00006059
• Brain Infusion of Muscimol to Treat EpilepsyTerminatedNCT00005925Phase 1
• Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic SeizuresCompletedNCT00004817Phase 3
• Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard TreatmentCompletedNCT00004758Phase 2
• Ketogenic Diet for Child Epilepsy and Seizure ControlCompletedNCT00004729Not applicable
• Double-Blind, Placebo-Controlled Trial of Vitamin E as Add-on Therapy for Children With EpilepsyCompletedNCT00004637Phase 4
• Serotonin Receptors in Seizure DisordersCompletedNCT00001932
• Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With EpilepsyCompletedNCT00001672
• Transcranial Magnetic Stimulation for the Treatment of Poorly Controlled Partial EpilepsyCompletedNCT00001666
• Effect of Vigabatrin on Brain Blood Flow and Glucose MetabolismCompletedNCT00001489
• Mapping the Areas of the Brain Associated With Language in Children With EpilepsyCompletedNCT00001366
• Metabolic Abnormalities in Children With EpilepsyCompletedNCT00001325
• Brain Blood Flow Studies of Language and MemoryCompletedNCT00001288
• Monitoring Patients With Uncontrolled EpilepsyCompletedNCT00001149