National Institutes of Health: Lipodystrophy trials

The registry lists 29 Lipodystrophy studies with National Institutes of Health as lead sponsor. 3 are open to participants now and 9 have results posted.

Phase 1 2Phase 2 10Phase 3 3Phase 4 1No phase 14(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Effects of Meal Macronutrients on Postprandial LipidsNot yet recruitingNCT07313787Phase 2
• Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)RecruitingNCT05996536
• Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With LipodystrophyRecruitingNCT05419037
• Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label ExtensionCompletedNCT02639286Phase 2Results posted
• Short-term Effects of Leptin in People With LipodystrophyCompletedNCT01778556Phase 2Results posted
• Myocardial Function & FFA Metabolism in HIV Metabolic SyndromeCompletedNCT00656851Not applicableResults posted
• Exercise and Pioglitazone for HIV-Metabolic SyndromesCompletedNCT00639457Not applicableResults posted
• Rosiglitazone Effect on Mitochondria and LipoatrophyCompletedNCT00367744Phase 2Results posted
• Effects of a Uridine Supplement on HIV Infected Adults With LipoatrophyCompletedNCT00307164Phase 2/3Results posted
• Observational Study of Fat Loss in HIV Infected Adults Taking Nucleoside Reverse Transcriptase Inhibitors (NRTIs)CompletedNCT00119405Results posted
• Effectiveness of Nucleoside Supplementation or Switch to Tenofovir in Reversing Fat Loss in HIV Infected AdultsCompletedNCT00119379Phase 2Results posted
• Leptin to Treat LipodystrophyCompletedNCT00025883Phase 2Results posted
• Compassionate Use of Metreleptin in Previously Treated People With Generalized LipodystrophyActive, not recruitingNCT02262832Phase 3
• Compassionate Use of Metreleptin in Previously Treated People With Partial LipodystrophyActive, not recruitingNCT02262806Phase 2
• Observational Study of Changes in Fat Distribution and Blood Metabolites in HIV Infected AdultsStatus unknownNCT00331448
• A Study of Physical and Metabolic Abnormalities in HIV Infected and Uninfected Children and YouthCompletedNCT00069004
• Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV PatientsCompletedNCT00028314Not applicable
• Changing to Nonprotease Inhibitor Treatment to Improve Side EffectsCompletedNCT00021463Phase 2
• The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering DrugsCompletedNCT00017758Phase 1
• Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat AbnormalitiesCompletedNCT00015691Not applicable
• Safety and Effectiveness of Fenofibrate and Pravastatin in HIV-Positive Patients With Abnormal Blood LipidsCompletedNCT00006412Phase 3
• Perceived Changes in Body Build and Image in Patients Who Are Now Taking or Recently Have Stopped Taking Anti-HIV DrugsCompletedNCT00006290
• A Study to Determine How and Why HIV-Infected Subjects on Anti-viral Treatment Develop LipodystrophyCompletedNCT00006190Phase 4
• Underlying Abnormalities in Fat and Muscle Leading to Lipodystrophy SyndromeCompletedNCT00006185Phase 1
• The Effect of Anti-HIV Treatment on Body Characteristics of HIV-Infected ChildrenCompletedNCT00006064
• Leptin to Treat LipodystrophyCompletedNCT00005905Phase 2
• Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional LipoatrophyCompletedNCT00004329
• Comparing Magnetic Resonance Imaging/Spectroscopy TechniquesTerminatedNCT00001219
• Metabolism and Body Shape of Healthy Children and Children With Chronic InfectionsCompletedNCT00001142