National Institutes of Health: Rectal Neoplasms trials

The registry lists 72 Rectal Neoplasms studies with National Institutes of Health as lead sponsor. 1 are open to participants now and 23 have results posted.

Early Phase 1 1Phase 1 37Phase 2 33Phase 3 7No phase 3(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 PatientsRecruitingNCT03190941Phase 1/2
• HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated CancersCompletedNCT04432597Phase 1/2Results posted
• Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal CancerTerminatedNCT04406857Phase 1Results posted
• Combination Immunotherapy in Subjects With Advanced HPV Associated MalignanciesCompletedNCT04287868Phase 1/2Results posted
• Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 PatientsTerminatedNCT03745326Phase 1/2Results posted
• Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal CancerTerminatedNCT03592641Phase 2Results posted
• Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal CancerTerminatedNCT03300544Phase 1Results posted
• Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal CancerCompletedNCT02921256Phase 2Results posted
• Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by SurgeryCompletedNCT01802320Phase 2Results posted
• Screening for Colorectal Cancer in Older Patients (PLCO Screening Trial)Active, not recruitingNCT01696981Not applicableResults posted
• A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the RectumTerminatedNCT01134601Phase 1Results posted
• RO4929097 in Treating Patients With Metastatic Colorectal CancerCompletedNCT01116687Phase 2Results posted
• Azacitidine and Entinostat in Treating Patients With Metastatic Colorectal CancerCompletedNCT01105377Phase 2Results posted
• Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by SurgeryTerminatedNCT00835679Early Phase 1Results posted
• Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or AdenomaCompletedNCT00754494Phase 2Results posted
• Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal CancerCompletedNCT00551421Phase 1/2Results posted
• Dasatinib in Treating Patients With Previously Treated Metastatic Colorectal CancerCompletedNCT00504153Phase 2Results posted
• Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line TherapyTerminatedNCT00499369Phase 3Results posted
• VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal CancerCompletedNCT00407654Phase 2Results posted
• AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer or Rectal CancerTerminatedNCT00397878Phase 2Results posted
• Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Nonmetastatic Rectal CancerCompletedNCT00321685Phase 2Results posted
• SB-715992 in Treating Patients With Advanced or Metastatic Colorectal CancerCompletedNCT00103311Phase 2Results posted
• Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal CancerCompletedNCT00100841Phase 2Results posted
• Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal CancerCompletedNCT00068692Phase 3Results posted
• Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF MutationActive, not recruitingNCT05308446Phase 2
• Therapy Adapted for High Risk and Low Risk HIV-Associated Anal CancerActive, not recruitingNCT04929028Phase 2
• Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal CancerActive, not recruitingNCT04751370Phase 2
• Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)Active, not recruitingNCT02465060Phase 2
• Ropidoxuridine in Treating Patients With Advanced Gastrointestinal Cancer Undergoing Radiation TherapyActive, not recruitingNCT02381561Phase 1
• Sorafenib Tosylate, Bevacizumab, Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Metastatic Colorectal CancerCompletedNCT01383343Phase 1
• Evaluation of Cancer Care Coordination in the National Cancer Institutes Community Cancer Center ProgramsCompletedNCT01346280
• Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients With Metastatic Colorectal CancerWithdrawnNCT01270438Phase 2
• Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck CancerCompletedNCT01254617Phase 1
• Veliparib, Oxaliplatin, and Capecitabine in Treating Patients With Advanced Solid TumorsTerminatedNCT01233505Phase 1
• Selumetinib and Cetuximab in Treating Patients With Refractory Solid TumorsCompletedNCT01217450Phase 1
• Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal CancerTerminatedNCT01198535Phase 1
• RO4929097 and Capecitabine in Treating Patients With Refractory Solid TumorsCompletedNCT01158274Phase 1
• Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid TumorsCompletedNCT01131234Phase 1
• Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung CancerTerminatedNCT00937482Phase 1
• Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By SurgeryCompletedNCT00433576Phase 1
• Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal CancerCompletedNCT00397384Phase 1
• Suberoylanilide Hydroxamic Acid, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Progressive Metastatic or Unresectable Colorectal Cancer or Other Solid TumorsCompletedNCT00138177Phase 1
• Sorafenib, Cetuximab, and Irinotecan in Treating Patients With Advanced or Metastatic Colorectal CancerCompletedNCT00134069Phase 1
• Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung CancerCompletedNCT00101348Phase 1/2
• Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With Metastatic Lung Cancer or Metastatic Colorectal CancerTerminatedNCT00088933Phase 1
• EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung CancerTerminatedNCT00087191Not applicable
• GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid TumorsCompletedNCT00084643Phase 1
• Bevacizumab and Cetuximab With or Without Irinotecan in Treating Patients With Irinotecan-Refractory Metastatic Colorectal CancerCompletedNCT00077298Phase 2
• Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With Resectable Liver Metastases Secondary to Colorectal CancerTerminatedNCT00070265Phase 2
• Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced, Metastatic, or Recurrent Colorectal CancerTerminatedNCT00070122Phase 3
• A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal CancerCompletedNCT00060411Phase 1
• Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal CancerTerminatedNCT00052585Phase 2
• Bevacizumab, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II or Stage III Rectal CancerCompletedNCT00052559Phase 1
• Imatinib Mesylate in Treating Patients With Stage IV Colorectal CancerCompletedNCT00041340Phase 2
• Erlotinib in Treating Patients With Recurrent or Metastatic Colorectal CancerCompletedNCT00032110Phase 2
• 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)CompletedNCT00031681Phase 1
• Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney DysfunctionCompletedNCT00030498Phase 1
• Vaccine Therapy With or Without Sargramostim in Treating Patients With Advanced or Metastatic CancerCompletedNCT00028496Phase 1
• Hepatic Arterial Infusion Plus Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the LiverCompletedNCT00026234Phase 2
• Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously TreatedCompletedNCT00025337Phase 3
• Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Recurrent or Persistent Metastatic Colorectal CancerCompletedNCT00023933Phase 1
• Vaccine Therapy in Treating Patients With Metastatic CancerCompletedNCT00020267Phase 1
• Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the LiverCompletedNCT00019760Phase 2
• Vaccine Therapy in Treating Patients With Colon, Pancreatic, or Lung CancerCompletedNCT00019006Phase 1
• Oxaliplatin, Fluorouracil, and External-Beam Radiation Therapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the RectumCompletedNCT00006094Phase 1/2
• SU5416 and Irinotecan in Treating Patients With Advanced Colorectal CancerCompletedNCT00005818Phase 1/2
• Celecoxib to Prevent Colorectal Cancer in Patients Who Have Undergone Surgery to Remove PolypsCompletedNCT00005094Phase 3
• Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal CancerCompletedNCT00005036Phase 3
• Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/NeuCompletedNCT00004074Phase 1
• Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal CancerCompletedNCT00003873Phase 3
• Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Rectal CancerCompletedNCT00003799Phase 1
• Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal CancerTerminatedNCT00002796Phase 1/2