National Cancer Institute (NCI) clinical trials
Listed in the registry as: U.S. National Institutes of Health.
The registry lists 3,554 studies whose lead sponsor is National Cancer Institute (NCI). 334 are recruiting or about to start. Per ClinicalTrials.gov, last updated Oct 23, 2026.
Keep track of what changes. Save the National Cancer Institute (NCI) studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesFocus areas
Conditions National Cancer Institute (NCI) leads ten or more studies in, by study count. A broader condition is left out when almost all its studies are already in a narrower one listed here.
Carcinoma341Lymphoma322Neoplasms318Leukemia271Breast Neoplasms253Lung Neoplasms224Melanoma199Prostatic Neoplasms185Lymphoma, Non-Hodgkin167Carcinoma, Non-Small-Cell Lung155Leukemia, Myeloid, Acute153Sarcoma145Multiple Myeloma135Precursor Cell Lymphoblastic Leukemia-Lymphoma131Neoplasm Metastasis121Glioblastoma120Carcinoma, Renal Cell118Leukemia, Lymphocytic, Chronic, B-Cell115Glioma112Pancreatic Neoplasms110Ovarian Neoplasms105Lymphoma, Large B-Cell, Diffuse104Adenocarcinoma99Myelodysplastic Syndromes98
Show all 195 areas
Carcinoma, Ovarian Epithelial85Colonic Neoplasms85Brain Neoplasms84Lymphoma, B-Cell84Colorectal Neoplasms83Lymphoma, Follicular82Gliosarcoma81Lymphoma, Mantle-Cell80Burkitt Lymphoma78Rectal Neoplasms71Fallopian Tube Neoplasms70Astrocytoma69Liver Neoplasms68Urinary Bladder Neoplasms66Hodgkin Disease65Neuroblastoma64Carcinoma, Squamous Cell61Kidney Neoplasms61Stomach Neoplasms61Carcinoma, Hepatocellular60Lymphoma, B-Cell, Marginal Zone60Squamous Cell Carcinoma of Head and Neck60Leukemia, Myelogenous, Chronic, BCR-ABL Positive59Small Cell Lung Carcinoma59Uterine Cervical Neoplasms57Head and Neck Neoplasms53Plasmablastic Lymphoma53Osteosarcoma52Oropharyngeal Neoplasms51Central Nervous System Neoplasms50Lymphoma, Large-Cell, Immunoblastic50Endometrial Neoplasms49Leukemia, Myelomonocytic, Acute49Waldenstrom Macroglobulinemia49Ependymoma48Breast Neoplasms, Male47Lymphoma, Large-Cell, Anaplastic47Carcinoma, Transitional Cell46Medulloblastoma46Mesothelioma46Hematologic Neoplasms45Lymphoma, T-Cell, Cutaneous45Sarcoma, Ewing45Thyroid Neoplasms45Esophageal Neoplasms44Oligodendroglioma44Skin Neoplasms44Leukemia, Myelomonocytic, Chronic43Mesothelioma, Malignant43Rhabdomyosarcoma43Leukemia, Erythroblastic, Acute42Leukemia, Monocytic, Acute42Leukemia-Lymphoma, Adult T-Cell41Leukemia, Megakaryoblastic, Acute41Mycosis Fungoides41Nasopharyngeal Carcinoma41Cholangiocarcinoma39HIV Infections39Laryngeal Neoplasms39Sarcoma, Kaposi38Sezary Syndrome37Neurofibromatosis 135Blast Crisis34Leukemia, Myelomonocytic, Juvenile34Lymphomatoid Granulomatosis34Triple Negative Breast Neoplasms34Salivary Gland Neoplasms33Immunoblastic Lymphadenopathy32Neuroectodermal Tumors, Primitive, Peripheral32Lymphoma, T-Cell, Peripheral31Myeloproliferative Disorders31Gastrointestinal Neoplasms30Leukemia, Hairy Cell30Neuroendocrine Tumors30Cystadenocarcinoma, Serous29Peritoneal Neoplasms29Lymphoma, Extranodal NK-T-Cell28Bile Duct Neoplasms27Gallbladder Neoplasms27Gastrointestinal Stromal Tumors26Neoplasms, Germ Cell and Embryonal26Adenocarcinoma of Lung25Anemia, Refractory, with Excess of Blasts25Carcinoma, Neuroendocrine25Intraocular Lymphoma25Wilms Tumor25Infections24Mouth Neoplasms23Paranasal Sinus Neoplasms23Carcinoma, Verrucous22Cystadenocarcinoma22Hypereosinophilic Syndrome22Leukemia, Promyelocytic, Acute22Ureteral Neoplasms22Anemia21Anus Neoplasms21Carcinoma, Endometrioid21Carcinosarcoma21Leiomyosarcoma21Lymphoproliferative Disorders21Melanoma, Cutaneous Malignant21Rhabdoid Tumor21Myelodysplastic-Myeloproliferative Diseases20Papillomavirus Infections20Adrenocortical Carcinoma19Carcinoma, Adenosquamous19Immunologic Deficiency Syndromes19Leukemia, Basophilic, Acute19Neurofibroma, Plexiform19Leukemia, Eosinophilic, Acute18Meningioma18Neoplasms, Unknown Primary18Pinealoma18Urethral Neoplasms18Leukemia, Myeloid, Accelerated Phase17Thyroid Cancer, Papillary17Adenocarcinoma, Bronchiolo-Alveolar16Adenocarcinoma, Clear Cell16Adenocarcinoma, Mucinous16Carcinoma in Situ16Carcinoma, Adenoid Cystic16Graft vs Host Disease16Hepatoblastoma16Leukemia, Prolymphocytic16Precursor T-Cell Lymphoblastic Leukemia-Lymphoma16Brenner Tumor15Carcinoma, Basal Cell15Histiocytosis, Langerhans-Cell15Leukemia, Large Granular Lymphocytic15Neurofibrosarcoma15Papilloma15Sarcoma, Synovial15Adenocarcinoma, Follicular14Carcinoid Tumor14Choroid Plexus Neoplasms14Communicable Diseases14Leukemia, Myeloid, Chronic-Phase14Pheochromocytoma14Primary Myelofibrosis14Thymoma14Tongue Neoplasms14Carcinoma, Intraductal, Noninfiltrating13Carcinoma, Medullary13Germinoma13Histiocytoma, Malignant Fibrous13Intestinal Neoplasms13Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative13Liposarcoma13Paraganglioma13Precancerous Conditions13Thymus Neoplasms13Carcinoma, Small Cell12Esthesioneuroblastoma, Olfactory12Malignant Carcinoid Syndrome12Rhabdomyosarcoma, Embryonal12Testicular Neoplasms12Uterine Cervical Dysplasia12Breast Carcinoma In Situ11Carcinoma, Mucoepidermoid11Craniopharyngioma11Inflammatory Breast Neoplasms11Mixed Tumor, Mullerian11Polycythemia Vera11Sarcoma, Alveolar Soft Part11Spinal Cord Neoplasms11Carcinoma, Islet Cell10Carcinoma, Merkel Cell10Hypopharyngeal Neoplasms10Nasopharyngeal Neoplasms10Philadelphia Chromosome10Urogenital Neoplasms10
Studies
Recruiting first, then most recently updated. Showing 50 of 3,554. Browse all 3,554 →
- A UGT1A1 Genotype-Directed Study of Belinostat Pharmacokinetics and ToxicityRecruitingNCT06406465Phase 2
- A Multicenter Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymph...RecruitingNCT05621291Not applicable
- Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous TreatmentRecruitingNCT05432804Phase 1/2
- Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous TreatmentRecruitingNCT06589804Phase 3
- Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])RecruitingNCT04267848Phase 3
- A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)RecruitingNCT06124157Phase 2
- BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot StudyRecruitingNCT05136196Phase 2
- Study of Preoperative Radiation Therapy in Participants With Resectable Recurrent Abdominal Adrenocortical CarcinomaRecruitingNCT06487481Phase 1
- A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and NivolumabRecruitingNCT05675410Phase 3
- Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN StudyRecruitingNCT05987241Phase 2/3
- Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition SyndromeRecruitingNCT04431024
- Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular LymphomaRecruitingNCT06337318Phase 3
- Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated SarcomasRecruitingNCT06422806Phase 3
- Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal CancerRecruitingNCT00050752
- Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE TrialRecruitingNCT06203600Phase 2/3
- Testing the Investigational Medication Combination of Daratumumab and Teclistamab Compared to the Usual Treatment (Daratumumab, Pomalidomide, Dexamethasone or Daratumumab, Carfilzomib, Dexamethasone) for Patients With High-risk Multiple Myeloma Refractory or in First RelapseRecruitingNCT06948084Phase 2
- Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic MalignanciesRecruitingNCT06904066Phase 1
- Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL StudyRecruitingNCT04269902Phase 3
- Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic CancerRecruitingNCT01174121Phase 2
- MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)RecruitingNCT05564390Phase 2
- Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast CancerRecruitingNCT06058377Phase 3
- Prospective Comprehensive Molecular Analysis of Endocrine NeoplasmsRecruitingNCT01005654
- Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative NeoplasmsRecruitingNCT06303193Phase 1/2
- Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the LungRecruitingNCT05058651Phase 2/3
- Clinical Genetics Branch Eligibility Screening SurveyNot yet recruitingNCT07005297
- A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid LeukemiaRecruitingNCT07012044Phase 1
- Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low TrialRecruitingNCT07391774Phase 3
- Multitargeted Recombinant Ad5 PSA/MUC-1/Brachyury-Based Immunotherapy (TriAdeno) Vaccine With IL-15 Superagonist N-803 in Participants With Clinically Localized Prostate Cancer Undergoing Active SurveillanceNot yet recruitingNCT07574541Phase 2
- NCI Childhood Cancer Data Initiative (CCDI) Led Pediatric, Adolescent, and Young Adult Rare Cancer Registry for Very Rare Solid TumorsRecruitingNCT07489378
- Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump TherapyNot yet recruitingNCT07715903Phase 1
- Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectable Brain MetastasesRecruitingNCT07619534
- Natural History Study of Early Life Exposures in Agriculture (ELEA)Enrolling by invitationNCT07328516
- Anti-CRLF2-R/TSLPR Chimeric Antigen Receptor T Cells (TSLPR-CART) in Participants With Recurrent or Refractory CRLF2-R/TSLPR-Overexpressing B-Cell Acute Lymphoblastic Leukemia (B-ALL)RecruitingNCT07572136Phase 1
- Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial CancerRecruitingNCT07198074Phase 3
- Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC TrialRecruitingNCT07388524Phase 3
- IL-12 Genetically Engineered Myeloid Cells in Participants With Relapsed, Refractory Solid TumorsRecruitingNCT07672483Phase 1
- Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood CancersNot yet recruitingNCT07524530Phase 2
- Docetaxel and SX-682 in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma, Salivary Gland Carcinoma, and Advanced Prostate CancerRecruitingNCT07667400Phase 1/2
- Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP)Not yet recruitingNCT07756840Phase 2
- Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young AdultsNot yet recruitingNCT07891286Phase 2
- Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE TrialRecruitingNCT06096844Phase 3
- Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung CancerRecruitingNCT04181060Phase 3
- Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary TumorsRecruitingNCT03866382Phase 2
- Gene Therapy Follow-up Protocol for People Previously Enrolled in CAR-T Cell StudiesEnrolling by invitationNCT02473757
- Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and HypercortisolismRecruitingNCT06246357Phase 2
- Follow Up Protocol for Subjects Previously Enrolled on NCI Surgery Branch StudiesEnrolling by invitationNCT00923026
- Clinical and Genetic Studies of Li-Fraumeni SyndromeRecruitingNCT01443468
- Connect for Cancer Prevention Study (Connect)RecruitingNCT04609072
- Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)RecruitingNCT06577441Phase 2
- Testing Teclistamab (TECVAYLI) in Combination With Iberdomide for Relapsed or Refractory Multiple MyelomaRecruitingNCT06465316Phase 1