National Institutes of Health: Anemia, Sickle Cell trials

The registry lists 84 Anemia, Sickle Cell studies with National Institutes of Health as lead sponsor. 9 are open to participants now and 15 have results posted.

Early Phase 1 3Phase 1 19Phase 2 21Phase 3 5No phase 44(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Partial Stem Cell Transplant for Sickle Cell Disease From Matched DonorsRecruitingNCT07599176Phase 1/2
• Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell DiseaseRecruitingNCT07566494Phase 1
• Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell DiseaseRecruitingNCT06944067
• Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin LabelingRecruitingNCT06313398Early Phase 1
• Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell DiseaseRecruitingNCT05904093Phase 1
• Dietary Intake and Dietary Behaviors in Adults With Sickle Cell DiseaseRecruitingNCT05170412
• Collection of Human Biospecimens for Basic and Clinical Research Into Globin VariantsRecruitingNCT03937817
• Blood Sampling for Research Related to Sickle Cell DiseaseRecruitingNCT00542230
• Blood Collection for Research Related to Certain Diseases Involving Blood VesselsEnrolling by invitationNCT00047996
• Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ FunctionActive, not recruitingNCT06145282Phase 1/2Results posted
• Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell DiseaseCompletedNCT04514510Phase 2Results posted
• Red Cell Half Life Determination in Patients With and Without Sickle Cell DiseaseCompletedNCT04476277Early Phase 1Results posted
• A Dose-Finding Study of AG-348 in Sickle Cell DiseaseCompletedNCT04000165Early Phase 1Results posted
• Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) PatientsCompletedNCT03226691Phase 1Results posted
• Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseActive, not recruitingNCT03077542Phase 1/2Results posted
• Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell DiseaseCompletedNCT02225132Phase 1/2Results posted
• Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant FailureActive, not recruitingNCT02105766Phase 2Results posted
• Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) Follow-up Observational Study II ProtocolCompletedNCT01783990Results posted
• Decitabine for High-Risk Sickle Cell DiseaseCompletedNCT01375608Phase 2Results posted
• Haploidentical PBMC Transplant for Severe Congenital AnemiasActive, not recruitingNCT00977691Phase 1/2Results posted
• Long-Term Effects of Hydroxyurea in Children With Sickle Cell Anemia (The BABY HUG Follow-up Study)CompletedNCT00890396Results posted
• Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell DiseaseTerminatedNCT00492531Phase 2Results posted
• Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital AnemiasActive, not recruitingNCT00061568Phase 1/2Results posted
• Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell AnemiaCompletedNCT00006400Phase 3Results posted
• Investigating the Mechanistic Effects of Mitapivat in Subjects With Sickle Cell DiseaseActive, not recruitingNCT05675436
• Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults With Sickle Cell Disease (SCD)SuspendedNCT05457790Not applicable
• Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-ThalassemiaActive, not recruitingNCT05357482Phase 1/2
• Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of MitapivatActive, not recruitingNCT04610866Phase 1/2
• Living With Sickle Cell Disease in the COVID-19 PandemicCompletedNCT04417673
• Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell TraitCompletedNCT04349189
• Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle NephropathyCompletedNCT03958643
• Motivations, Expectations, and Decision-making of Sickle Cell Patients in Clinical ResearchCompletedNCT03709303
• Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary HypertensionCompletedNCT03572036
• Early Diagnosis of Sickle Acute Chest Syndrome Using a Combination of Plasma Bimarkers and Chest ImagingCompletedNCT03478917
• Examining the Knowledge, Attitudes, and Beliefs of Sickle Cell Disease Patients, Parents of Patients With Sickle Cell Disease, and Providers Towards the Integration of CRISPR in Clinical CareCompletedNCT03167450
• Pathophysiology of Acute Pain in Patients With Sickle Cell DiseaseCompletedNCT03049475
• Fertility Preservation in Women Who Will Have Gonadotoxic Therapy or Hematopoetic Stem Cell Transplantation, and in Women With Sickle Cell DiseaseCompletedNCT02225145
• Evaluation of Sickle Cell Liver DiseaseCompletedNCT01950429
• Validating Pain Scales in Children and Young AdultsCompletedNCT01639950
• Developing the Family Map: Looking at Communal CopingCompletedNCT01633021
• Microvessels and Heart Problems in Sickle Cell DiseaseCompletedNCT01602809
• Blood Flow and Pain Crises in People With Sickle Cell DiseaseCompletedNCT01568710
• Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell DiseaseWithdrawnNCT01568645Phase 1
• Carbon Monoxide Levels and Sickle Cell Disease SeverityCompletedNCT01547793
• Genetics and Pain Severity in Sickle Cell DiseaseCompletedNCT01441141
• Nitric Oxide and Sickle Cell PainTerminatedNCT01393847
• Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood DisordersCompletedNCT01316796Phase 1
• Screening for Subjects to Participate in Studies of Blood DisordersCompletedNCT00695123
• Establishing a Database of People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Data Project [C-Data])TerminatedNCT00529061
• Establishing a Repository of Blood and DNA Samples From People With Sickle Cell Disease (Comprehensive Sickle Cell Centers Collaborative Genotype-Phenotype Database and Sample Repository)TerminatedNCT00528203
• Niacin to Improve Blood Flow in People With Sickle Cell DiseaseCompletedNCT00508989Phase 2
• Pulmonary Hypertension, Hypoxia and Sickle Cell DiseaseCompletedNCT00495638
• The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell DiseaseCompletedNCT00451919
• Hypnosis to Manage Pain and Symptoms in Patients With Sickle Cell DiseaseCompletedNCT00393250Phase 3
• Pulmonary Hypertension in Patients With Sickle Cell Disease in NigeriaCompletedNCT00367523
• Hydroxyurea and Erythropoietin to Treat Sickle Cell AnemiaCompletedNCT00270478Phase 1
• Heart Disease in Sickle Cell AnemiaCompletedNCT00113152
• Therapeutic Application of Intravascular Nitrite for Sickle Cell DiseaseCompletedNCT00095472Phase 1
• Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell DiseaseCompletedNCT00072826Phase 1
• Home Based Massage and Relaxation for Sickle Cell PainCompletedNCT00066079Phase 2
• Transcranial Doppler (TCD) Ultrasound of Subjects Enrolled in BABY HUG - Ancillary to BABY HUGCompletedNCT00059293
• Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell AnemiaCompletedNCT00056433Phase 1
• Pediatrics:Chlamydia, Sickle Cell Anemia and Stroke Risk - Ancillary to STOP IICompletedNCT00037388
• Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or ThalassemiaTerminatedNCT00034528Phase 2
• Induction of Stable Chimerism for Sickle Cell AnemiaCompletedNCT00029393Phase 2
• Cord Blood Transplantation for Sickle Cell Anemia and ThalassemiaCompletedNCT00029380Phase 2
• Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary HypertensionCompletedNCT00023296Phase 1
• Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell DiseaseCompletedNCT00012545
• Secondary Pulmonary Hypertension in Adults With Sickle Cell AnemiaCompletedNCT00011648
• Nitric Oxide to Improve Blood Flow in Sickle Cell DiseaseCompletedNCT00009581Phase 2
• Stroke Prevention in Sickle Cell Anemia (STOP 2)CompletedNCT00006182Phase 3
• A Phase I/II Trial of Recombinant-Methionyl Human Stem Cell Factor (SCF) in Adult Patients With Sickling DisordersCompletedNCT00005783Phase 1
• Hemostasis in Sickle Cell Disease--Infancy to AdulthoodCompletedNCT00005703
• Indices of Severity and Prognosis for Sickle Cell DiseaseCompletedNCT00005467
• Neuropsychological Studies of Children With Sickle CellCompletedNCT00005438
• Cerebrovascular Involvement in Sickle Cell Disease - Comprehensive Sickle Cell CenterCompletedNCT00005326
• Investigation of Selected Patient Groups From The Cooperative Study of Sickle Cell DiseaseCompletedNCT00005300
• Cooperative Study of The Clinical Course of Sickle Cell DiseaseCompletedNCT00005277
• Pilot Study of Fructose for Sickle Cell CrisisCompletedNCT00004797Not applicable
• Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell AnemiaCompletedNCT00001716Phase 2
• Hydroxyurea for the Treatment of Patients With Sickle Cell AnemiaCompletedNCT00001197Phase 2
• Pediatric Hydroxyurea in Sickle Cell Anemia (PED HUG)CompletedNCT00000602Phase 2
• Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH)CompletedNCT00000586Phase 3
• Penicillin Prophylaxis in Sickle Cell Disease (PROPS)CompletedNCT00000585Phase 3