National Institute of Mental Health (NIMH) clinical trials
Listed in the registry as: U.S. National Institutes of Health.
The registry lists 367 studies whose lead sponsor is National Institute of Mental Health (NIMH). 45 are recruiting or about to start. Per ClinicalTrials.gov, last updated Oct 23, 2026.
Keep track of what changes. Save the National Institute of Mental Health (NIMH) studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesFocus areas
Conditions National Institute of Mental Health (NIMH) leads ten or more studies in, by study count. A broader condition is left out when almost all its studies are already in a narrower one listed here.
Depression87Depressive Disorder65Depressive Disorder, Major47Mood Disorders39Bipolar Disorder38Schizophrenia35Mental Disorders24Attention Deficit Disorder with Hyperactivity17Autistic Disorder17Autism Spectrum Disorder15Obsessive-Compulsive Disorder15Alzheimer Disease14Psychotic Disorders13Stress Disorders, Post-Traumatic11
Studies
Recruiting first, then most recently updated. Showing 50 of 367. Browse all 367 →
- Brain Stimulation and Vision TestingRecruitingNCT01617408
- Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy VolunteersRecruitingNCT06484088Early Phase 1
- PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)RecruitingNCT07169630Phase 1
- Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive PsychotherapyRecruitingNCT07640802
- Augmenting Parent Management Training for Child Temper Outbursts Using a Digital ToolRecruitingNCT07764536
- First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE4D Imaging in Healthy VolunteersRecruitingNCT07853781Phase 1
- A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying PubertyRecruitingNCT01434368
- Characterization and Treatment of Adolescent DepressionRecruitingNCT03388606
- A Longitudinal Natural History Study of Immune Biomarkers in Neuropsychiatric IllnessRecruitingNCT07877246
- PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use DisorderRecruitingNCT06795581Phase 1
- Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) ArrayRecruitingNCT04950309Not applicable
- Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderRecruitingNCT03065335Phase 1
- Studies of Blood Flow to the Brain During ThoughtRecruitingNCT00001360
- Study of Neuro-Cognitive Correlates of Pediatric Anxiety DisordersRecruitingNCT00018057Phase 2
- Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety DisordersRecruitingNCT00397111
- Neurobiology of SuicideRecruitingNCT02543983Phase 2
- Defining the Brain Phenotype of Children With Williams SyndromeRecruitingNCT01132885
- MRS Measurement of Glutamate and GABA Metabolism in BrainRecruitingNCT00109174Not applicable
- Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric AnxietyRecruitingNCT06595953Phase 2
- Ecological Momentary Assessment of State-Dependent Decision-Making and Metacognition Across a Psychopathology ContinuumNot yet recruitingNCT07801079
- Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II TrialRecruitingNCT05608434Phase 1/2
- Psychological Treatments for Youth With Severe Irritability.RecruitingNCT02531893
- Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and MuscleRecruitingNCT01266577Not applicable
- NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar DisorderRecruitingNCT05669703
- Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionRecruitingNCT06511908Phase 2
- Role of Theta Frequency Oscillations in Proactive and Reactive Control Processes in Youth With Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)RecruitingNCT07566468
- State-dependent Interoception, Value-based Decision-making, and IntrospectionRecruitingNCT05666726Not applicable
- Evaluation of Patients With Mood and Anxiety Disorders and Healthy VolunteersRecruitingNCT00024635
- Natural History of Depression, Bipolar Disorder and Suicide RiskRecruitingNCT06462196
- [18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PETRecruitingNCT05703685Phase 1
- Long-term Observation of Participants With Mood DisordersRecruitingNCT04877977
- Evaluation of [11C]ZTP-1 to Image PDE4BRecruitingNCT07625345Phase 1
- The Neurodevelopmental and Behavioral Phenotyping Screening ProtocolRecruitingNCT00271622
- PET Imaging of Noradrenergic Transmission in the BrainRecruitingNCT07686393Phase 1
- Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural StudiesRecruitingNCT03304665
- Developing Brain, Impulsivity and CompulsivityRecruitingNCT04631042
- Studies of Brain Function and Course of Illness in Pediatric Bipolar DisorderRecruitingNCT00025935
- PET Imaging of Cyclooxygenases in Neurodegenerative Brain DiseaseRecruitingNCT04396873Phase 1
- Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionRecruitingNCT03973268Phase 1
- Top-Down Attentional Control of Visual-ProcessingRecruitingNCT01087281
- PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)RecruitingNCT04582916Phase 1
- Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy VolunteersRecruitingNCT06874205Phase 1
- PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)RecruitingNCT06920628Phase 1
- Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)RecruitingNCT07027839Phase 1
- Role of GABAergic Transmission in Auditory Processing in Autism Spectrum DisorderRecruitingNCT04798274Not applicable
- Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy VolunteersCompletedNCT00001246
- Perimenopause-Related Mood and Behavioral DisordersCompletedNCT00001231
- Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric PopulationsActive, not recruitingNCT04639830
- Studying Childhood-onset Behavioral, Psychiatric, and Developmental DisordersCompletedNCT01778504
- Studies of Frontal Lobe Brain Functioning in SchizophreniaCompletedNCT00001258