National Institutes of Health: Bronchiolitis Obliterans Syndrome trials

The registry lists 24 Bronchiolitis Obliterans Syndrome studies with National Institutes of Health as lead sponsor. 3 are open to participants now and 12 have results posted.

Phase 1 4Phase 2 17No phase 7(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic MalignanciesRecruitingNCT05327023Phase 1/2
• Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic MalignanciesRecruitingNCT04959175Phase 1/2
• Evaluation of Patients With Immune Function AbnormalitiesRecruitingNCT00128973
• Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-mediated CytopeniasTerminatedNCT05502783Phase 2Results posted
• Front Line Ibrutinib Without Corticosteroids for Newly Diagnosed Chronic Graft-versus-Host DiseaseCompletedNCT04294641Phase 2Results posted
• Topical Ruxolitinib for Cutaneous Chronic Graft Versus Host Disease (cGVHD)TerminatedNCT03395340Phase 2Results posted
• Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell TransplantationCompletedNCT02759731Phase 1/2Results posted
• Vismodegib in Treating Patients With Steroid-Refractory Chronic Graft-Versus-Host DiseaseTerminatedNCT02337517Phase 2Results posted
• A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) PatientsTerminatedNCT01972438Phase 2Results posted
• Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans SyndromeCompletedNCT01287078Phase 2Results posted
• Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis ObliteransCompletedNCT01273207Phase 2Results posted
• Imatinib Mesylate to Treat Skin Changes in Patients With Chronic Graft-Versus-Host DiseaseCompletedNCT00702689Phase 2Results posted
• Montelukast to Treat Bronchiolitis ObliteransCompletedNCT00656058Phase 2Results posted
• Dexamethasone to Prevent Oral Chronic Graft-versus-Host DiseaseCompletedNCT00391170Phase 2Results posted
• Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related StomatitisTerminatedNCT00075023Phase 2Results posted
• Study to Determine the Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects With Chronic Liver DiseaseCompletedNCT05669677
• Extension Study (Extended Access) of Syk-inhibition Using Fostamatinib to Treat Posttransplant Immune-mediated CytopeniasWithdrawnNCT05509582Phase 2
• Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell TransplantationActive, not recruitingNCT02669251Phase 1/2
• CLAD Phenotype Specific Risk Factors and MechanismsCompletedNCT02631720
• Development and Validation of a Symptom Scale for Children With Chronic Graft-versus-Host DiseaseCompletedNCT01036958
• Viral Triggers in Pediatric Lung TransplantationCompletedNCT00891865
• Can Immune Parameters Predict Acute and Chronic Rejection in Lung Recipients?CompletedNCT00340951
• Extracorporeal Photopheresis to Treat Chronic Graft-Versus-Host DiseaseCompletedNCT00048789Phase 2
• Popcorn Lung: the Discovery of a New DiseaseCompletedNCT00027235