National Institutes of Health: Cystic Fibrosis trials

The registry lists 33 Cystic Fibrosis studies with National Institutes of Health as lead sponsor. 3 are open to participants now and 1 have results posted.

Phase 1 4Phase 2 4Phase 3 3No phase 23(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Natural History of Noncirrhotic Portal HypertensionRecruitingNCT02417740
• Natural History of BronchiectasisRecruitingNCT00943514
• Role of Genetic Factors in the Development of Lung DiseaseRecruitingNCT00001532
• A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas AeruginosaCompletedNCT05453578Phase 1/2Results posted
• Longitudinal Assessment of Transient Elastography in Cystic FibrosisCompletedNCT03001388
• MRI to Characterize and Predict CF Liver Disease in PUSH CohortCompletedNCT02979340
• Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial InfectionCompletedNCT01150721
• Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic FibrosisCompletedNCT01144507
• Disclosing a Cystic Fibrosis Diagnosis to a Dating PartnerCompletedNCT00485082
• Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung DiseaseCompletedNCT00368446
• Increased Gluconeogenesis is One Cause of Cystic Fibrosis Related Diabetes (CFRD)CompletedNCT00082238Not applicable
• Diabetes Therapy to Improve BMI and Lung Function in CFCompletedNCT00072904Phase 3
• The Role of Bacteria and Genetic Variations in Cystic FibrosisCompletedNCT00043225
• Role of Toxins in Lung Infections Caused by Pseudomonas AeruginosaCompletedNCT00027183
• Quantification of Pulmonary Neutrophil Activity in Cystic Fibrosis Using Radiolabeled Fluorodeoxyglucose and PET ImagingStatus unknownNCT00023465
• Tissue Collection From People With Cystic FibrosisCompletedNCT00015756
• Benefits and Risks of Newborn Screening for Cystic FibrosisCompletedNCT00014950Not applicable
• Study of Metabolic Effects of Pregnancy in Women With Cystic FibrosisTerminatedNCT00014768
• Pressure Support Ventilation During CF ExacerbationsSuspendedNCT00008775Not applicable
• Bone Health of People With Cystic FibrosisCompletedNCT00008762
• A Study of the Safety and Efficacy of Tobramycin for Inhalation in Young Children With Cystic FibrosisCompletedNCT00006280Phase 2
• Study of Total Energy Expenditure in Infants and Children With Moderate to Severe Cystic FibrosisStatus unknownNCT00006273
• Behavioral Treatment of Weight Gain in CFCompletedNCT00006169Phase 3
• Randomized Study of Pancrelipase With Bicarbonate (PANCRECARB) Capsules in Reducing Steatorrhea in Patients With Cystic FibrosisCompletedNCT00006063Not applicable
• Growth Hormone Use in Cystic Fibrosis - a Multicenter StudyCompletedNCT00005112Phase 3
• A Multi-Centered Study of the Long-Term Effect of Salmeterol and Albuterol in Cystic FibrosisSuspendedNCT00005110Not applicable
• Phase I Pilot Study of Ad5-CB-CFTR, an Adenovirus Vector Containing the Cystic Fibrosis Transmembrane Conductance Regulator Gene, in Patients With Cystic FibrosisCompletedNCT00004779Phase 1
• Phase II Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Mucoid Exopolysaccharide Pseudomonas Aeruginosa Immune Globulin for Cystic FibrosisCompletedNCT00004747Phase 2
• Phase I Randomized Study of Adeno-Associated Virus-CFTR Vector in Patients With Cystic FibrosisCompletedNCT00004533Phase 1
• Phase II Pilot Study to Compare the Bioavailability of Buffered, Enteric-Coated Ursodiol With Unmodified Ursodiol for Chronic Cholestatic Liver Disease and Cystic Fibrosis-Associated Liver DiseaseStatus unknownNCT00004315Phase 2
• Multicenter Study of Nontuberculous Mycobacteria in Cystic Fibrosis PatientsCompletedNCT00004296
• Phase I Study of the Third Generation Adenovirus H5.001CBCFTR in Patients With Cystic FibrosisCompletedNCT00004287Phase 1
• Diagnosis and Treatment of Patients With Cystic FibrosisTerminatedNCT00001223