National Institutes of Health: Colorectal Neoplasms, Hereditary Nonpolyposis trials
The registry lists 10 Colorectal Neoplasms, Hereditary Nonpolyposis studies with National Institutes of Health as lead sponsor. 1 are open to participants now and 1 have results posted.
Phase 1 5Phase 2 2Phase 3 1No phase 3(a study in two phases counts in both)
Studies
Open to participants first, then studies with results posted, then the rest; newest registration first within each.
- Men at High Genetic Risk for Prostate CancerRecruitingNCT03805919
- Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch RepairActive, not recruitingNCT02912559Phase 3Results posted
- Testing a Combination of Vaccines for Cancer Prevention in Lynch SyndromeActive, not recruitingNCT05419011Phase 2
- Cancer Preventive Vaccine Nous-209 for Lynch Syndrome PatientsActive, not recruitingNCT05078866Phase 1/2
- Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI StudyWithdrawnNCT04500548Phase 1
- Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or MedulloblastomaActive, not recruitingNCT02359565Phase 1
- Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch SyndromeCompletedNCT02052908Phase 1
- Uncertain Genetic Test Results for Lynch SyndromeCompletedNCT01646112
- Psychosocial Aspects of Genetic Testing for Hereditary Nonpolyposis Colon CancerCompletedNCT00341575
- Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and CarriersCompletedNCT00001693Phase 1