National Institutes of Health: Down Syndrome trials

The registry lists 10 Down Syndrome studies with National Institutes of Health as lead sponsor. 2 are open to participants now and 0 have results posted.

Phase 2 1Phase 3 1No phase 8(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without ThymectomyRecruitingNCT07416201
• A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)RecruitingNCT04546399Phase 2
• A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic LeukemiaActive, not recruitingNCT03914625Phase 3
• Parent Supported Weight Reduction in Down SyndromeCompletedNCT01256112Not applicable
• Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and DementiaStatus unknownNCT00966017
• Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down SyndromeStatus unknownNCT00965835
• The Experience of Caregivers of Children With Down SyndromeCompletedNCT00695695
• Down Syndrome - Comparison of Screening Methods in the 1st and 2nd TrimestersStatus unknownNCT00006445Not applicable
• Reproduction and Survival After Cardiac Defect RepairCompletedNCT00005190
• Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian DisordersTerminatedNCT00001178