National Institutes of Health: Von Hippel-Lindau Disease trials

The registry lists 12 Von Hippel-Lindau Disease studies with National Institutes of Health as lead sponsor. 0 are open to participants now and 6 have results posted.

Phase 1 5Phase 2 5No phase 4(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist RanibizumabCompletedNCT02859441Phase 1/2Results posted
• Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine TumorsCompletedNCT01967537Phase 2Results posted
• Sunitinib Malate to Treat Advanced Eye Disease in Patients With Von Hippel-Lindau SyndromeTerminatedNCT00673816Phase 1/2Results posted
• Phase II Study of Vandetanib in Individuals With Kidney CancerCompletedNCT00566995Phase 2Results posted
• 17AAG to Treat Kidney Tumors in Von Hippel-Lindau DiseaseCompletedNCT00088374Phase 2Results posted
• Natural History and Management of Pancreatic Lesions in Von Hippel-Lindau DiseaseCompletedNCT00062166Results posted
• Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)CompletedNCT02108002Phase 1
• Ranibizumab Injections to Treat Retinal Tumors in Patients With Von Hippel-Lindau SyndromeCompletedNCT00089765Phase 1
• Genetic Study to Identify Gene Mutations in Participants Previously Enrolled in Clinical Trial NCI-99-C-0053 Who Have Von Hippel-Lindau Syndrome or Are at Risk for Von Hippel-Lindau SyndromeCompletedNCT00075348
• EYE001 to Treat Retinal Tumors in Patients With Von Hippel-Lindau SyndromeCompletedNCT00056199Phase 1
• Von Hippel-Lindau Disease Genetic Epidemiology StudyTerminatedNCT00001803
• Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac TumorsCompletedNCT00001668