National Institutes of Health: Diabetes Mellitus trials

The registry lists 155 Diabetes Mellitus studies with National Institutes of Health as lead sponsor. 12 are open to participants now and 23 have results posted.

Early Phase 1 1Phase 1 16Phase 2 41Phase 3 10Phase 4 4No phase 86(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Evaluation of the Clinical Spectrum of Diabetes and Obesity in Youth and AdultsNot yet recruitingNCT07388537
• Effects of Meal Macronutrients on Postprandial LipidsNot yet recruitingNCT07313787Phase 2
• A Natural History Study of Metabolic Sizing in Health and DiseaseRecruitingNCT05398783
• Caregiving Networks Across Disease Context and the Life CourseRecruitingNCT05007990
• Early Tracking of Childhood Health Determinants (ETCHED) StudyRecruitingNCT03481829
• Taste Bud-Derived Stem Cells in HumansRecruitingNCT03366168
• New Heart Imaging Techniques to Evaluate Possible Heart DiseaseRecruitingNCT01399385Not applicable
• Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora PopulationsEnrolling by invitationNCT01316783
• Personalized Environment and Genes StudyRecruitingNCT00341237
• Urinary Vitamin C Loss in Diabetic SubjectsRecruitingNCT00071526
• Genetic Studies of Insulin and DiabetesRecruitingNCT00001987
• Diabetes and Heart Disease Risk in BlacksRecruitingNCT00001853
• Prebiotics and Metformin Improve Gut and Hormones in Type 2 Diabetes in Youth (MIGHTY-fiber)CompletedNCT04209075Phase 2Results posted
• Hydroxychloroquine in Individuals At-risk for Type 1 Diabetes MellitusTerminatedNCT03428945Phase 2Results posted
• Title: Therapeutic Targets in African-American Youth With Type 2 DiabetesCompletedNCT02960659Phase 1/2Results posted
• Tocilizumab (TCZ) in New-onset Type 1 DiabetesCompletedNCT02293837Phase 2Results posted
• ATG-GCSF in New Onset Type 1 DiabetesCompletedNCT02215200Phase 2Results posted
• Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and DiabetesCompletedNCT02107976Not applicableResults posted
• CTLA4-Ig (Abatacept)for Prevention of Abnormal Glucose Tolerance and Diabetes in Relatives At -Risk for Type 1CompletedNCT01773707Phase 2Results posted
• A Research Trial of Aralast in New Onset Diabetes (RETAIN)TerminatedNCT01183468Phase 1Results posted
• Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk"CompletedNCT01030861Phase 2Results posted
• Inducing Remission in Type 1 Diabetes With AlefaceptTerminatedNCT00965458Phase 2Results posted
• Canakinumab Study in Individuals With Newly Diagnosed Type 1 DiabetesCompletedNCT00947427Phase 2Results posted
• Novel Therapy to Preserve Beta Cell Function in New Onset Type 1 DiabetesTerminatedNCT00837759Phase 2Results posted
• Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset SubjectsCompletedNCT00529399Phase 2Results posted
• Study of Antithymocyte Globulin for Treatment of New-onset T1DMTerminatedNCT00515099Phase 2Results posted
• Intravenous CTLA4-lg Treatment in Recent Onset Type 1 Diabetes MellitusCompletedNCT00505375Phase 2Results posted
• Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes MellitusCompletedNCT00419562Phase 3Results posted
• The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy VolunteersCompletedNCT00339833Phase 4Results posted
• Rituximab in New Onset Type 1 DiabetesCompletedNCT00279305Phase 2Results posted
• Autoimmunity-blocking Antibody for Tolerance in Recently Diagnosed Type 1 DiabetesCompletedNCT00129259Phase 2Results posted
• New Onset of Type 1 Diabetes Mycophenolate Mofetil-Daclizumab Clinical TrialCompletedNCT00100178Phase 2Results posted
• Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY)CompletedNCT00081328Phase 3Results posted
• Diabetes Prevention Program Outcomes StudyCompletedNCT00038727Phase 3Results posted
• Action to Control Cardiovascular Risk in Diabetes (ACCORD)CompletedNCT00000620Phase 3Results posted
• Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With ObesityCompletedNCT05017571Phase 2
• The Influence of Malnutrition, Diabetes Mellitus, and Helminth Infections on Biosignatures in Latent Tuberculosis in a South Indian PopulationCompletedNCT04526613
• Dietary Behavior Intervention in African Americans at Risk for Cardiovascular DiseaseActive, not recruitingNCT04305431Not applicable
• People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral AgentsActive, not recruitingNCT03520660Phase 4
• Methyldopa for Reduction of DQ8 Antigen Presentation in At-Risk Subjects for Type 1 DiabetesWithdrawnNCT03396484Phase 2
• Compassionate Use of Metreleptin in Previously Treated People With Generalized LipodystrophyActive, not recruitingNCT02262832Phase 3
• Compassionate Use of Metreleptin in Previously Treated People With Partial LipodystrophyActive, not recruitingNCT02262806Phase 2
• Links Between Inflammation and Cardiometabolic DiseasesCompletedNCT01934660
• Identifying Risk for Diabetes and Heart Disease in WomenCompletedNCT01809288
• Developing the Family Map: Looking at Communal CopingCompletedNCT01633021
• Healthy Lifestyle in PregnancyWithdrawnNCT01585454
• Family Genetics Health Education and Healthy BehaviorsCompletedNCT01498276
• TODAY2 Phase 1 Immediate Post-Intervention Observational Follow-up StudyCompletedNCT01364350
• Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS)Active, not recruitingNCT01323322
• Immunosuppressive Medications for Participants in ITN005CT (NCT00014911)No longer availableNCT01309022
• CARDIA Brain MRI SubstudyCompletedNCT01273311
• A Research Trial of Aralast NP in New Onset Diabetes (RETAIN) - Part IIWithdrawnNCT01183455Phase 2
• Type 2 Diabetes and Obesity in Mexican Pimas: Gene-Environment InteractionCompletedNCT01168297
• Molecular and Clinical Profile of Diabetes Mellitus and Its ComplicationsSuspendedNCT01105858
• Effects of Caloric Restriction Alone Versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients With Diabetes MellitusTerminatedNCT01083108Phase 2
• Partners for Better Health in Adolescent Type 2 Diabetes: The Buddy StudyCompletedNCT01007266Phase 2
• Cultivating Healthy Environments in Families With Type 1 Diabetes (CHEF)CompletedNCT00999375Phase 2
• Natural History of Autoimmune Diabetes and Its ComplicationsTerminatedNCT00896610
• Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese WomenCompletedNCT00862433Phase 1
• Community Health Workers in Diabetes Care in American SamoaCompletedNCT00850824Not applicable
• Adolescent Self-Management of Type 1 Diabetes: an Intervention (Completed)CompletedNCT00848705Early Phase 1
• Parental Management of Young Children's DiabetesCompletedNCT00847327Not applicable
• Genetics of Type 2 Diabetes Among Han ChineseCompletedNCT00837408
• Genetics of Type 2 Diabetes in West AfricansCompletedNCT00837122
• Treatment With hOKT3gamma1(Ala-Ala) in T1DMTerminatedNCT00806572Phase 2
• Assessment of Beta Cell Mass by PET Scans With [11C] Dihydrotetrabenazine (DTBZ) in Longstanding Type 1 Diabetes.CompletedNCT00738907
• A Trial of Two Diets for Weight and Diabetes ManagementCompletedNCT00729196Not applicable
• Circuit Training and Motivational Interviewing to Reduce Type 2 Diabetes in YouthCompletedNCT00693511Not applicable
• Effect of Physical Activity on Metabolic Syndrome in Pregnancy & Fetal OutcomeCompletedNCT00647595Phase 3
• Computer Based Intervention for Type 2 Diabetes in YouthCompletedNCT00570466Not applicable
• Relation of White Blood Cell Function to DiabetesCompletedNCT00570154
• Blood Glucose Response to Meals of Varying Glycemic Index in Youth With Type 1 & 2 DiabetesCompletedNCT00545727Not applicable
• Changing Physical Activity Behavior in Individuals With Type 2 Diabetes Using Counceling and Information From Continuous Glucose MonitoringCompletedNCT00542698Phase 1
• Proleukin and Rapamune in Type 1 DiabetesCompletedNCT00525889Phase 1
• Risk Communication Within Mexican-American FamiliesCompletedNCT00469339
• Strategies to Improve Islet SurvivalCompletedNCT00464555Phase 2
• Middle-School Based Primary Prevention Trial of Type 2 DiabetesCompletedNCT00458029Not applicable
• Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 DiabetesCompletedNCT00434850Phase 2
• Islet Transplantation in Type 1 DiabetesCompletedNCT00434811Phase 3
• Preventing Depression Recurrence in DiabetesCompletedNCT00374426Phase 4
• Assessment of Beta Cell Mass in Type 1 Diabetes With 11C-Dihydrotetrabenazine and PET ScanCompletedNCT00351650
• Family Investigation of Nephropathy and Diabetes (F.I.N.D.)Active, not recruitingNCT00342927
• Family Management of Childhood Diabetes StudyCompletedNCT00340938Phase 1
• Management of Type 1 Diabetes Among AdolescentsCompletedNCT00340639
• Diabetes Management Personal TrainerCompletedNCT00340093Phase 1
• Mapping Genes for Type 2 (Non-Insulin Dependent) Diabetes MellitusCompletedNCT00339885
• Predictive and Protective Factors in the Cause of Diabetes - A Study in TwinsCompletedNCT00339781
• Prospective Studies of the Natural History of Diabetes Mellitus and Its Complications in the Gila River Indian CommunityCompletedNCT00339482
• Food Intake and Appetite in the Children of Mothers With DiabetesCompletedNCT00339313
• Nutritional Intervention to Prevent DiabetesCompletedNCT00333554Not applicable
• The Family Investigation of Nephropathy and Diabetes StudyCompletedNCT00301249
• The Diabetes TeleCare StudyCompletedNCT00288132Not applicable
• Family Management of Type 1 Diabetes in ChildrenCompletedNCT00273286Phase 2
• A Self-care Intervention for Latino Adults With DiabetesCompletedNCT00263835Phase 2
• Use of Midlevel Providers in Diabetes ManagementCompletedNCT00237094Not applicable
• A Study of the Function of Hormones Present In Taste BudsCompletedNCT00233298
• Iron Depletion Therapy for Type 2 DM and NAFLDCompletedNCT00230087Not applicable
• T Cell Validation Study Using Blood Samples From Subjects With Recent Onset Type 1 Diabetes MellitusCompletedNCT00212329
• Exercise Training in Type 2 Diabetes and HypertensionCompletedNCT00212303Phase 4
• Breaking Down Barriers to Diabetes Self-CareCompletedNCT00142922Not applicable