National Institutes of Health: Graft vs Host Disease trials

The registry lists 54 Graft vs Host Disease studies with National Institutes of Health as lead sponsor. 4 are open to participants now and 24 have results posted.

Early Phase 1 1Phase 1 12Phase 2 31Phase 3 3No phase 14(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Phase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)RecruitingNCT05531786Phase 1/2
• Evaluation of Patients With Immune Function AbnormalitiesRecruitingNCT00128973
• Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell TransplantsRecruitingNCT00106925
• Improved Methods of Cell Selection for Bone Marrow Transplant AlternativesRecruitingNCT00001529
• Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-mediated CytopeniasTerminatedNCT05502783Phase 2Results posted
• Topical Ruxolitinib for Cutaneous Chronic Graft Versus Host Disease (cGVHD)TerminatedNCT03395340Phase 2Results posted
• Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseActive, not recruitingNCT03077542Phase 1/2Results posted
• Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell TransplantationCompletedNCT02759731Phase 1/2Results posted
• Early Treatment of Acute Graft Versus Host Disease With Bone Marrow-Derived Mesenchymal Stem Cells and CorticosteroidsTerminatedNCT02379442Phase 1/2Results posted
• Calcineurin Inhibitor-Free Interventions BMT CTN 1301 for Prevention of Graft-versus-Host Disease (BMT CTN 1301)CompletedNCT02345850Phase 3Results posted
• Vismodegib in Treating Patients With Steroid-Refractory Chronic Graft-Versus-Host DiseaseTerminatedNCT02337517Phase 2Results posted
• Biomarkers in Acute Graft-Versus-Host Disease and Extracorporeal Photopheresis Added to Investigator Chosen Therapies of Steroid Refractory Acute GVHDTerminatedNCT02322190Phase 2Results posted
• Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)CompletedNCT02208037Phase 2Results posted
• Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant FailureActive, not recruitingNCT02105766Phase 2Results posted
• A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) PatientsTerminatedNCT01972438Phase 2Results posted
• Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological MalignanciesCompletedNCT01789255Phase 2Results posted
• Pomalidomide for Chronic Graft-versus-Host DiseaseCompletedNCT01688466Phase 2Results posted
• Clobetasol for Oral Graft-Versus-Host DiseaseCompletedNCT01557517Phase 2Results posted
• Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans SyndromeCompletedNCT01287078Phase 2Results posted
• Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis ObliteransCompletedNCT01273207Phase 2Results posted
• Haploidentical PBMC Transplant for Severe Congenital AnemiasActive, not recruitingNCT00977691Phase 1/2Results posted
• Low-Intensity Stem Cell Transplantation With Multiple Lymphocyte Infusions to Treat Advanced Kidney CancerCompletedNCT00923845Phase 2Results posted
• Imatinib Mesylate to Treat Skin Changes in Patients With Chronic Graft-Versus-Host DiseaseCompletedNCT00702689Phase 2Results posted
• Montelukast to Treat Bronchiolitis ObliteransCompletedNCT00656058Phase 2Results posted
• Dexamethasone to Prevent Oral Chronic Graft-versus-Host DiseaseCompletedNCT00391170Phase 2Results posted
• Treatment for Acute Graft-Versus-Host Disease (BMT CTN 0302)CompletedNCT00224874Phase 2Results posted
• Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related StomatitisTerminatedNCT00075023Phase 2Results posted
• Selective T-Cell Depletion to Reduce GVHD (Patients) Receiving Stem Cell Tx to Treat Leukemia, Lymphoma or MDSCompletedNCT00025662Phase 2Results posted
• Extension Study (Extended Access) of Syk-inhibition Using Fostamatinib to Treat Posttransplant Immune-mediated CytopeniasWithdrawnNCT05509582Phase 2
• Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and SirolimusWithdrawnNCT04370795Phase 1/2
• Pediatric cGVHD Symptom ScaleActive, not recruitingNCT04044365
• Optimizing PTCy Dose and TimingActive, not recruitingNCT03983850Phase 1/2
• Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant CyclophosphamideActive, not recruitingNCT03910452Early Phase 1
• Chronic Graft-versus-Host Disease in the Oral Cavity of Patients Following Allogeneic Hematopoietic Stem Cell Transplant and Including Healthy ControlsCompletedNCT03602599
• Evaluation of Budesonide and How It Interacts With Antifungal Drugs in People With Gastrointestinal Graft-Versus-Host DiseaseTerminatedNCT01950507Phase 1
• Collection of Saliva and/ or Peripheral Blood From Healthy Volunteers for ResearchCompletedNCT01851382
• Bone Marrow Stromal Cell Infusions for Stem Cell Transplant ComplicationsCompletedNCT01633229Phase 1
• The Natural History of Graft-Versus-Host Disease in the EyesCompletedNCT01369914
• Development and Validation of a Symptom Scale for Children With Chronic Graft-versus-Host DiseaseCompletedNCT01036958
• Natural History and Pathophysiology of Gastrointestinal Graft-versus-Host DiseaseWithdrawnNCT00723593
• Cyclosporine Implant for Ocular Graft-Versus-Host DiseaseCompletedNCT00102583Phase 1
• Extracorporeal Photopheresis to Treat Chronic Graft-Versus-Host DiseaseCompletedNCT00048789Phase 2
• Blood and Marrow Transplant Clinical Research NetworkCompletedNCT00023530Not applicable
• Potential of Transplanted Stem Cells to Mature Into Salivary Gland and Cheek CellsCompletedNCT00023491
• Study of the Pharmacokinetics of Mycophenolate Mofetil in Patients Who Have Undergone Orthotopic Liver TransplantationCompletedNCT00007059Not applicable
• The Role of Cyclosporine in Blood Cell Transplants With T-Cell Add-Back for Blood CancersCompletedNCT00001873Phase 2
• Cell Selection for Bone Marrow Transplants to Prevent Graft-Versus-Host-DiseaseCompletedNCT00001872
• Donor Th2 Cells to Prevent Graft-Versus-Host Disease in Bone Marrow TransplantsCompletedNCT00001830Phase 1
• HLA-Mismatched Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematological MalignanciesCompletedNCT00001748Phase 1
• Immunosuppressive Preparation Followed by Blood Cell Transplant for the Treatment of Blood Cancers in Older AdultsCompletedNCT00001637Phase 2
• Bone Marrow Transplant Studies for Safe and Effective Treatment of LeukemiaCompletedNCT00001623Not applicable
• Active Immunization of Sibling Bone Marrow Transplant Donors Against Purified Myeloma Protein of the Recipient Undergoing Allogeneic Bone Marrow TransplantationCompletedNCT00001561Phase 3
• Modified Bone Marrow Stem Cell Transplantation for Chronic Myelogenous LeukemiaCompletedNCT00001144Phase 2
• T-Cell Depletion in Unrelated Donor Marrow TransplantationCompletedNCT00000591Phase 3