National Institutes of Health: Colorectal Neoplasms trials

The registry lists 91 Colorectal Neoplasms studies with National Institutes of Health as lead sponsor. 19 are open to participants now and 25 have results posted.

Phase 1 33Phase 2 53Phase 3 2No phase 11(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump TherapyNot yet recruitingNCT07715903Phase 1
• Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat TrialRecruitingNCT07551596Phase 2
• Natural History Study of Early Life Exposures in Agriculture (ELEA)Enrolling by invitationNCT07328516
• Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal CancerRecruitingNCT07147231Phase 1/2
• The Vanguard Study: Testing a New Way to Screen for CancerRecruitingNCT06995898Not applicable
• Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal CancerRecruitingNCT06696768Phase 1
• Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal CancerRecruitingNCT06654037Phase 1
• An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous PolyposisRecruitingNCT06557733Phase 2
• Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)RecruitingNCT06149481Phase 1/2
• Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal CancerRecruitingNCT06102902Phase 1
• Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable CancersRecruitingNCT05803382Phase 1
• Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and EffectivenessRecruitingNCT05691491Phase 1/2
• Testing for Safety and Colorectal Cancer Preventive Effects of ONC201RecruitingNCT05630794Phase 1
• PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical CarcinomaRecruitingNCT05286814Phase 2
• Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal HistologiesRecruitingNCT04847063Phase 1
• Metarrestin (ML-246) in Subjects With Metastatic Solid TumorsRecruitingNCT04222413Phase 1
• Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of CancerRecruitingNCT01915225
• Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic CancerRecruitingNCT01174121Phase 2
• Evaluation for NCI Surgery Branch Clinical Research ProtocolsRecruitingNCT00001823
• Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal CarcinomatosisCompletedNCT05185947Phase 2Results posted
• Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and IntestinesActive, not recruitingNCT04535401Phase 1Results posted
• Phase II Trial of Combination Immunotherapy in Subjects With Advanced Small Bowel and Colorectal CancersCompletedNCT04491955Phase 2Results posted
• VB-111 in Combination With Nivolumab in People With Metastatic Colorectal Cancer (mCRC)TerminatedNCT04166383Phase 2Results posted
• Nivolumab (Anti-PD1), Tadalafil and Oral Vancomycin in People With Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer From Colorectal or Pancreatic CancersTerminatedNCT03785210Phase 2Results posted
• Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal CancerTerminatedNCT03592641Phase 2Results posted
• Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the LiverCompletedNCT03366155Phase 2Results posted
• Dolcanatide in Preventing Colorectal Cancer in Healthy VolunteersCompletedNCT03300570Phase 1Results posted
• A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory Colorectal CancerCompletedNCT03206073Phase 1/2Results posted
• Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated Metastatic Colorectal Cancer QUILT-2.004TerminatedNCT03050814Phase 2Results posted
• Aspirin in Preventing Colorectal Cancer in Patients With Colorectal AdenomaActive, not recruitingNCT02965703Phase 2Results posted
• Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of Developing Colon CancerCompletedNCT02961374Phase 2Results posted
• Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung CancerActive, not recruitingNCT02888743Phase 2Results posted
• AMP-224, a PD-1 Inhibitor, With Stereotactic Body Radiation Therapy in Metastatic Colorectal CancerCompletedNCT02298946Phase 1Results posted
• Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon PolypsActive, not recruitingNCT02134925Phase 2Results posted
• Surgery Plus Sulindac or Surgery Alone for Advanced Colorectal CancerTerminatedNCT01856322Phase 2Results posted
• ISIS 183750 With Irinotecan for Advanced Solid Tumors or Colorectal CancerCompletedNCT01675128Phase 1/2Results posted
• MK-2206 and AZD6244 in Patients With Advanced Colorectal CarcinomaCompletedNCT01333475Phase 2Results posted
• Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMICompletedNCT01312467Phase 2Results posted
• A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H...CompletedNCT00923481Phase 2Results posted
• Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal CancerCompletedNCT00828984Phase 2Results posted
• Curcumin in Treating Patients With Familial Adenomatous PolyposisCompletedNCT00641147Phase 2Results posted
• BAY 43-9006 Plus Cetuximab to Treat Colorectal CancerCompletedNCT00326495Phase 2Results posted
• Celecoxib With or Without Eflornithine in Preventing Colorectal Cancer in Patients With Familial Adenomatous PolyposisCompletedNCT00033371Phase 2Results posted
• Surgery With or Without Thalidomide in Treating Patients With Recurrent or Metastatic Colorectal CancerTerminatedNCT00019747Phase 2Results posted
• CBX-12 for the Treatment of Metastatic Chemotherapy-Refractory Microsatellite Stable Colorectal CancerWithdrawnNCT06730100Phase 2
• A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal MalignanciesWithdrawnNCT06690281Phase 2
• Immunotherapies in Combination With Stereotactic Body Radiation Radiotherapy in Microsatellite Stable (MSS) Metastatic Colorectal Cancer (mCRC)WithdrawnNCT06603818Phase 2
• A Phase II Study Evaluating an Organ Preservation Strategy Using Immune Checkpoint Blockade for Participants With Primary Colorectal or Gastroesophageal CancerWithdrawnNCT06410534Phase 2
• Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic CancerActive, not recruitingNCT06253520Phase 1
• Testing a Combination of Vaccines for Cancer Prevention in Lynch SyndromeActive, not recruitingNCT05419011Phase 2
• Testing Obeticholic Acid for Familial Adenomatous PolyposisTerminatedNCT05223036Phase 2
• Cancer Preventive Vaccine Nous-209 for Lynch Syndrome PatientsActive, not recruitingNCT05078866Phase 1/2
• Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH TrialActive, not recruitingNCT04704661Phase 1
• National Cancer Institute "Cancer Moonshot Biobank"Active, not recruitingNCT04314401
• Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer, Moonshot StudyCompletedNCT03707574
• Testing the Addition of Atezolizumab to Combination Chemotherapy or Atezolizumab Alone for Metastatic Colon or Rectal Cancer, the COMMIT StudyActive, not recruitingNCT02997228Phase 3
• M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by SurgeryActive, not recruitingNCT02595931Phase 1
• Phase I/II Study of the Anti-Programmed Death Ligand-1 Durvalumab Antibody (MEDI4736) in Combination With Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal Can...Active, not recruitingNCT02484404Phase 1/2
• Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)Active, not recruitingNCT02465060Phase 2
• Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced CancerActive, not recruitingNCT02298959Phase 1
• Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal CancerCompletedNCT02188264Phase 1
• Colon Cancer Study of Fecal Samples in Shanghai, ChinaCompletedNCT01778595
• Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver DysfunctionCompletedNCT01638533Phase 1
• TKM 080301 for Primary or Secondary Liver CancerCompletedNCT01437007Phase 1
• Safety and Pharmacokinetics of Treating Liver Cancer With Drug-Eluting BeadsTerminatedNCT01336985Phase 1
• Prospective Randomized Trial Evaluating Mandatory Second Look Surgery With HIPEC and CRS vs. Standard of Care in Subjects at High Risk of Developing Colorectal Peritoneal MetastasesWithdrawnNCT01095523Phase 2
• An Open Label Phase I Study to Eval the Safety and Tolerability of a Vaccine (GI-6207) Consisting of Whole, Heat-killed Recombinant Saccharomyces Cerevisiae (Yeast) Genetically Modified to Express CEA Protein in Adults With Metastatic CEA-expressing ...CompletedNCT00924092Phase 1
• The Natural History of Solid Organ Cancer Stem Cells (SOCSC)TerminatedNCT00923052
• Studying a Quality of Life Questionnaire in Patients With Colorectal CancerCompletedNCT00564694
• Isolated Hepatic Perfusion With Melphalan Followed by Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal CancerCompletedNCT00103298Phase 2
• Isolated Hepatic Perfusion With Melphalan in Treating Patients With Unresectable Colorectal Cancer That Has Metastasized to the LiverCompletedNCT00089401Phase 2
• Bevacizumab Plus Fluorouracil and Leucovorin in Treating Patients With Locally Advanced or Metastatic Stage IV Colorectal Cancer That Has Progressed After Standard ChemotherapyCompletedNCT00066846Phase 2
• Celecoxib in Preventing Cancer in Patients With Rectal Polyps or Colorectal NeoplasiaCompletedNCT00043043Phase 2
• Massage Therapy for Cancer-Related FatigueCompletedNCT00039793Phase 2
• Combination Chemotherapy in Treating Patients With Advanced Colorectal CancerCompletedNCT00039611Not applicable
• Acupuncture to Reduce Symptoms of Advanced Colorectal CancerCompletedNCT00034034Phase 1
• ZD 1839 Plus Combination Chemotherapy in Treating Patients With Locally Advanced, Locally Recurrent, or Metastatic Colorectal CancerCompletedNCT00026364Phase 1
• Chemotherapy With or Without Isolated Hepatic Perfusion With Melphalan in Treating Patients With Colorectal Cancer That Has Spread to the LiverCompletedNCT00020501Phase 3
• Vaccine Therapy in Treating Patients With Metastatic CancerCompletedNCT00020267Phase 1
• Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colorectal Cancer That is Metastatic to the LiverCompletedNCT00019760Phase 2
• Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Locally Advanced or Metastatic Colorectal CancerCompletedNCT00019591Phase 1/2
• Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Previously Treated With IrinotecanCompletedNCT00016978Phase 2
• Combination Chemotherapy Plus Trastuzumab in Treating Patients With Advanced, Recurrent, or Metastatic Colorectal CancerTerminatedNCT00006015Phase 2
• SU5416 in Treating Patients With Metastatic or Locally Recurrent Colorectal CancerTerminatedNCT00006001Phase 2
• Rebeccamycin Analog in Treating Patients With Metastatic or Locally Recurrent Colorectal CancerCompletedNCT00005085Phase 2
• Study of the Results of Education and Counseling for Persons Undergoing Genetic Testing for Hereditary Nonpolyposis Colon CancerCompletedNCT00004210Not applicable
• Monoclonal Antibody Plus Chemotherapy in Treating Patients With Advanced Colorectal Cancer That Overexpresses HER2CompletedNCT00003995Phase 2
• Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and CarriersCompletedNCT00001693Phase 1
• A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the LiverCompletedNCT00001576Phase 1
• Phase II Study of the Role of Anti-CEA Antibody Immunoscintigraphy & Positron Emission Tomography in the Localization of Recurrent Colorectal Carcinoma in Patients With Rising Serum CEA Levels in the Absence of Imageable Disease by Conventional ModalitiesCompletedNCT00001568Phase 2
• A Phase II Study of 5-Fluorouracil Administered as a One Hour Infusion in Combination With Calcium Leucovorin and Interferon Alpha-2A in Advanced Colorectal CancerCompletedNCT00001428Phase 2