National Institutes of Health: Alcoholism trials

The registry lists 89 Alcoholism studies with National Institutes of Health as lead sponsor. 17 are open to participants now and 22 have results posted.

Early Phase 1 2Phase 1 14Phase 2 37Phase 3 2Phase 4 8No phase 30(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)RecruitingNCT07559500Phase 1
• Human Laboratory Study of Apremilast for Alcohol Use DisorderRecruitingNCT07325266Phase 2
• Hepatic Lipid Metabolism-Alcohol Use DisorderRecruitingNCT07191561
• Tirzepatide in MetALDRecruitingNCT07046819Phase 2
• Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)RecruitingNCT07027839Phase 1
• Environment and Alcohol: A Pilot StudyRecruitingNCT06860607Phase 1
• PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use DisorderRecruitingNCT06795581Phase 1
• The Impact of Heavy Alcohol Use on Saliva and Oral HealthRecruitingNCT06684483
• SMART-r: Substance Monitoring and Active Relapse Tracking RepositoryRecruitingNCT06676059
• Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRPRecruitingNCT06552741
• Suvorexant for Alcohol Use Disorder (AUD): Neural MechanismsRecruitingNCT06484075Phase 1/2
• Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use DisorderRecruitingNCT06269627Phase 4
• Spironolactone in Alcohol Use Disorder (SAUD)RecruitingNCT05807139Phase 1
• Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)RecruitingNCT05677321
• Addictions Neuroclinical Assessment (ANA)Enrolling by invitationNCT04946851
• COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History StudyRecruitingNCT04391816
• NIAAA Natural History ProtocolRecruitingNCT02231840
• Human Laboratory Study of ASP8062 for Alcohol Use DisorderCompletedNCT05096117Phase 2Results posted
• HLAB-002 of ANS-6637 for Alcohol Use DisorderTerminatedNCT03970109Phase 2Results posted
• Manipulating Ghrelin Signaling Via GOAT Inhibition in Alcohol Use DisorderCompletedNCT03896516Phase 1/2Results posted
• Intranasal Oxytocin for the Treatment of Alcohol Use DisorderCompletedNCT03878316Phase 2Results posted
• RCT of Web-Based Behavioral Sleep Intervention for Individuals With Alcohol Use DisorderCompletedNCT03493958Not applicableResults posted
• Ketogenic Diet (KD) in AlcoholismCompletedNCT03255031Not applicableResults posted
• Human Laboratory Study of Varenicline for Alcohol Use DisorderCompletedNCT03035708Phase 1/2Results posted
• A Novel Compound for Alcoholism Treatment: A Translational Strategy - Part IITerminatedNCT02707055Phase 2Results posted
• HORIZANT (Gabapentin Enacarbil Extended-Release Tablets) for the Treatment of Alcohol Use DisorderCompletedNCT02252536Phase 2Results posted
• Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy DrinkersCompletedNCT01779024Phase 2Results posted
• Baclofen for Treating Anxiety and AlcoholismCompletedNCT01751386Phase 2Results posted
• Role of Proinflammatory Signaling in Alcohol CravingTerminatedNCT01631630Phase 2Results posted
• ABT-436 for Alcohol DependenceCompletedNCT01613014Phase 2Results posted
• Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism in Anxious Alcoholics^CompletedNCT01227980Phase 2Results posted
• CRF1 Antagonist GSK561679 in AlcoholismCompletedNCT01187511Phase 2Results posted
• Varenicline for Alcohol DependenceCompletedNCT01146613Phase 2Results posted
• Levetiracetam XR in Very Heavy DrinkersCompletedNCT00970814Phase 2Results posted
• The Effect of NK1R Antagonism on Alcohol Craving and PTSD Symptoms in Alcohol Dependent Patients With PTSDCompletedNCT00896038Phase 2Results posted
• Modulation of Pharmacologically Induced Alcohol Craving in Recently Detoxified AlcoholicsCompletedNCT00605904Phase 2Results posted
• Study of the Effectiveness of Quetiapine for the Treatment of Alcohol DependencyCompletedNCT00498628Phase 2Results posted
• Effect of LY686017 on Alcohol CravingCompletedNCT00310427Phase 2Results posted
• Acamprosate to Reduce Symptoms of Alcohol WithdrawalCompletedNCT00106106Phase 2Results posted
• Semaglutide Therapy for Alcohol Reduction (STAR)Active, not recruitingNCT06015893Phase 2
• Exploring Gut-Brain and Brain-Gut Interactions in Alcohol Use Disorder Via Microbiota Investigations: A Pilot StudyCompletedNCT03152760
• Oxytocin in Alcohol Use DisorderWithdrawnNCT02711189Phase 1
• Study of Structural ImagingCompletedNCT02564991
• Epi-Genetic Modulators of Fear Extinction in Alcohol DependenceCompletedNCT02438969
• Brain Inflammation and Function in AlcoholismCompletedNCT02233868Early Phase 1
• Traits Associated With Early Life Stress Among Treatment-Seeking AlcoholicsWithdrawnNCT02181608
• Sleep Disturbance and Relapse in Individuals With Alcohol Dependence: An Exploratory Mixed Methods StudyCompletedNCT02181569
• Neural Substrates of Approach-Avoidance ConflictCompletedNCT02119624
• Characterization Imaging Instruments in Alcoholics and Non-AlcoholicsCompletedNCT02108080
• Behavioral and Functional Task Development, Implementation, and TestingCompletedNCT02108054Not applicable
• A Novel Compound for Alcoholism TreatmentCompletedNCT02039349Phase 1
• Deep Brain Stimulation for Refractory AlcoholismWithdrawnNCT01798888Phase 1
• Evaluating Alternative Aftercare Models for Ex-offendersCompletedNCT01586689Phase 2
• Genetics of the Acute Response to Alcohol in Social DrinkersTerminatedNCT01375556Phase 1
• Aripiprazole and Topiramate on Free-Choice Alcohol UseCompletedNCT00884884Phase 2/3
• Alcohol Early Intervention for FreshmenStatus unknownNCT00852033Not applicable
• Imaging Cannabinoid CB1 Receptors in Alcohol DependenceCompletedNCT00816439
• Cognitive Behavioral Stress Management for HIV+ Drug AbusersCompletedNCT00722644Phase 1
• The Effect of Naltrexone on Alcohol Craving and on Brain Activity During Alcohol InfusionCompletedNCT00667771Early Phase 1
• Aftercare for Adolescents Treated for Alcohol Abuse and DependenceCompletedNCT00561041Phase 2
• The Stress-Hormone System in Alcohol-Dependent SubjectsCompletedNCT00536146
• Student Athlete Testing Using Random NotificationCompletedNCT00451854Not applicable
• Medication and Counseling for Controlled Drinking (Project SMART)CompletedNCT00444418Phase 3
• OPRM1 A118G SNP, Alcohol Response, and Striatal DopamineCompletedNCT00401999
• Individualized Treatment Program for Alcohol ProblemsCompletedNCT00298792Phase 1
• Treatment of Patients With Alcoholism and Attention Deficit DisorderCompletedNCT00261872Phase 4
• A Placebo-Controlled Trial of Memantine for Alcohol DependenceCompletedNCT00246415Phase 2
• Project RAP: Reaching Adolescents for PreventionStatus unknownNCT00183157Phase 2
• Alcoholism Assessment and TreatmentCompletedNCT00106093
• Serotonin Transporters in AlcoholismCompletedNCT00085865
• Bupropion as a Smoking Cessation Aid in AlcoholicsCompletedNCT00044434Phase 4
• Combined Pharmacotherapies for Alcoholism (Naltrexone/Ondansetron)CompletedNCT00027079Phase 2
• Serotonin in AlcoholismCompletedNCT00011752
• Comparing Gabapentin and Lorazepam for Treating Alcohol WithdrawalCompletedNCT00011297Phase 2
• Preliminary Human Trial of NPI-028WithdrawnNCT00010907Phase 2
• Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)CompletedNCT00006204Phase 4
• The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and NonalcoholicsCompletedNCT00001675
• Screening Evaluation for Studies of the National Institute on Alcohol Abuse and Alcoholism (NIAAA)CompletedNCT00001673
• Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex TraitsCompletedNCT00001500
• Genetic Factors and Interrelationships for Sexual Orientation, Susceptibility to HIV and Kaposi's Sarcoma, Alcoholism and Psychological Traits, and Histocompatibility AntigensCompletedNCT00001294
• Sertraline and Cognitive Therapy in Depressed AlcoholicsCompletedNCT00000458Phase 2
• Naltrexone Treatment of Alcohol DependenceCompletedNCT00000452Phase 4
• Behavior and Naltrexone Treatment for AlcoholicsCompletedNCT00000449Phase 4
• Drug Treatment for Alcoholics With Post-Traumatic Stress DisorderCompletedNCT00000446Phase 2
• Use of Naltrexone in a Clinical SettingCompletedNCT00000445Phase 4
• Ondansetron Treatment for AlcoholismCompletedNCT00000443Phase 2
• Drug Therapy for Alcohol DetoxificationCompletedNCT00000441Phase 4
• Sertraline and Naltrexone for Alcohol DependenceCompletedNCT00000440Phase 2
• Drug Treatment for Alcoholics With Bipolar DisorderCompletedNCT00000439Phase 2