National Institutes of Health: Infections trials

The registry lists 375 Infections studies with National Institutes of Health as lead sponsor. 16 are open to participants now and 43 have results posted.

Phase 1 89Phase 2 100Phase 3 47Phase 4 7No phase 144(a study in two phases counts in both)

Studies

Page 1 of 4. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Rechallenge With a Low Pathogenicity Avian H10N7 Influenza Virus in Healthy Human Volunteers Previously Challenged With H10N7 InfluenzaEnrolling by invitationNCT07215871Phase 1
• High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) RecipientsRecruitingNCT05947071Phase 2
• NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)RecruitingNCT05189925Phase 1
• Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)RecruitingNCT05026138
• Inflammatory and Infectious Diseases of the Nervous SystemRecruitingNCT02435810
• Pathogenesis and Genetics of Disseminated or Refractory CoccidioidomycosisRecruitingNCT02190266
• Improving White Blood Cell Collection From Healthy DonorsRecruitingNCT01553214Phase 4
• Diagnosis and Management of Inflammatory and Infectious DiseasesRecruitingNCT00557726
• Evaluation of Patients With Immune Function AbnormalitiesRecruitingNCT00128973
• Study of Lung Proteins in Patients With PneumoniaRecruitingNCT00077909
• Evaluation, Treatment, and Follow-up of Patients With Lyme DiseaseRecruitingNCT00028080
• Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)RecruitingNCT00006150
• Study of Chediak-Higashi SyndromeRecruitingNCT00005917
• Recruitment and Apheresis Collection of Peripheral Blood Hematopoietic Stem Cells, Mononuclear Cells and GranulocytesRecruitingNCT00001405
• Detection and Characterization of Host Defense DefectsRecruitingNCT00001355
• Evaluation and Long-Term Follow-up of Patients With Inflammatory DisordersEnrolling by invitationNCT00001351
• A Clinical Trial to Evaluate the Safety and Immunogenicity of BG505 MD39.3, BG505 MD39.3 gp151, and BG505 MD39.3 gp151 CD4KO HIV Trimer mRNA Vaccines in Healthy, HIV-uninfected Adult ParticipantsActive, not recruitingNCT05217641Phase 1Results posted
• Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial)CompletedNCT04870138Phase 1Results posted
• A Study of SARS CoV-2 Infection and Potential Transmission in Individuals Immunized With Moderna COVID-19 VaccineCompletedNCT04811664Phase 3Results posted
• Evaluating the Safety and Immunogenicity of AGS-v PLUS, a Universal Mosquito-Borne Disease and Mosquito Control VaccineCompletedNCT04009824Phase 1Results posted
• Clinical Study of a Diagnostic Device for NG, TV and CT in WomenCompletedNCT03852316Not applicableResults posted
• Experimental Human Infection With Neisseria GonorrhoeaeCompletedNCT03840811Phase 1Results posted
• Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS)TerminatedNCT03697993Phase 4Results posted
• Challenge Infection of Healthy Adult Volunteers With RSV A2CompletedNCT03388645Phase 1Results posted
• Placebo-Controlled Trial of Antibiotic Therapy in Adults With Suspect Lower Respiratory Tract Infection (LRTI) and a Procalcitonin LevelTerminatedNCT03341273Not applicableResults posted
• Asymptomatic Congenital CMV TreatmentTerminatedNCT03301415Phase 2Results posted
• YCFM (Youth Correctional Facilities Males)CompletedNCT03249935Phase 2Results posted
• VRC 705: A Zika Virus DNA Vaccine in Healthy Adults and AdolescentsCompletedNCT03110770Phase 2Results posted
• Evaluating the Safety and Pharmacokinetics of Maraviroc in HIV-1-Exposed Infants at Risk of Acquiring HIV-1 InfectionCompletedNCT02778204Phase 1Results posted
• Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection Among Men and Transgender Persons Who Have Sex With MenCompletedNCT02716675Phase 2Results posted
• Safety and Therapeutic Efficacy of the VRC01 Antibody in Patients Who Initiated Antiretroviral Therapy During Early Acute HIV InfectionCompletedNCT02664415Phase 2Results posted
• Evaluating the Safety and Efficacy of the VRC01 Antibody in Reducing Acquisition of HIV-1 Infection in WomenCompletedNCT02568215Phase 2Results posted
• A Safety and Immune Response Study of 2 Experimental HIV VaccinesCompletedNCT02404311Phase 1/2Results posted
• Putative Investigational Therapeutics in the Treatment of Patients With Known Ebola InfectionCompletedNCT02363322Phase 1/2Results posted
• Plerixafor Versus G-CSF in the Treatment of People With WHIM SyndromeCompletedNCT02231879Phase 2/3Results posted
• Evaluating the Safety and Effectiveness of Interferon-Free Treatment of Hepatitis C Virus Infection in HIV-Coinfected Adults on Antiretroviral TherapyTerminatedNCT02194998Phase 2Results posted
• Safety and Effectiveness of Low-Dose Methotrexate for Reducing Inflammation in HIV-Infected Adults on ARV MedicationsCompletedNCT01949116Phase 2Results posted
• Cabozantinib S-Malate in Treating Patients With Advanced Solid Tumors and Human Immunodeficiency VirusCompletedNCT01822522Phase 1Results posted
• Safety and Pharmacokinetics of Raltegravir in HIV-1-Exposed Newborn Infants at Risk of Acquiring HIV-1 InfectionCompletedNCT01780831Phase 1Results posted
• Valganciclovir Therapy in Infants and Children With Congenital CMV Infection and Hearing LossCompletedNCT01649869Phase 2Results posted
• The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children"CompletedNCT01595529Phase 2Results posted
• Evaluating the Safety and Tolerability of Antiretroviral Drug Regimens Used as Pre-Exposure Prophylaxis to Prevent HIV Infection in At-Risk Men Who Have Sex With Men and in At-Risk WomenCompletedNCT01505114Phase 2Results posted
• Evaluating the Effectiveness of Boceprevir, Pegylated-Interferon Alfa 2b and Ribavirin in Treating Hepatitis C Virus (HCV) Infection in Adults With HIV and HCV InfectionCompletedNCT01482767Phase 3Results posted
• Quadrivalent HPV Vaccine to Prevent Anal HPV in HIV-infected Men and WomenCompletedNCT01461096Phase 3Results posted
• Brief Rifapentine-Isoniazid Evaluation for TB Prevention (BRIEF TB)CompletedNCT01404312Phase 3Results posted
• A Safety and Tolerability Study of Nitazoxanide in HIV-HCV Treatment FailuresCompletedNCT01185028Phase 1/2Results posted
• Nitazoxanide Plus Ribavirin and Peginterferon for Therapy of Treatment Naive HCV Genotype 1 and HIV Coinfected SubjectsCompletedNCT00991289Phase 2Results posted
• Safety and Immune Response of a Rotavirus Vaccine in HIV-infected and Uninfected Children Born to HIV-infected MothersCompletedNCT00880698Phase 2Results posted
• Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-Resistant Staphylococcus AureusCompletedNCT00730028Phase 2Results posted
• Effect of Ranitidine on Hyper-IgE Recurrent Infection (Job's) SyndromeTerminatedNCT00527878Phase 2Results posted
• Short-Term vs. Long-Term Valganciclovir Therapy for Symptomatic Congenital CMV InfectionsCompletedNCT00466817Phase 3Results posted
• Pioglitazone to Treat Fatty Liver in People With HIV InfectionCompletedNCT00441272Phase 2Results posted
• Development of Immune Globulin Treatment for Avian FluTerminatedNCT00383071Phase 2Results posted
• Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug UsersTerminatedNCT00270257Phase 3Results posted
• Effect of Intermittent Aldesleukin Treatment With or Without Anti-HIV Drugs in HIV Infected PeopleCompletedNCT00110812Phase 2Results posted
• Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at BirthCompletedNCT00102960Phase 3Results posted
• Cyclosporine A in Combination With Abacavir Sulfate, Lamivudine, and Zidovudine and Lopinavir/Ritonavir in HIVCompletedNCT00084149Phase 2Results posted
• Peginterferon Alpha-2b And Ribavirin to Treat Hepatitis C in HIV-Infected PatientsCompletedNCT00018031Phase 2Results posted
• An International Study to Evaluate Recombinant Interleukin-2 in HIV Positive Patients Taking Anti-retroviral TherapyCompletedNCT00004978Phase 3Results posted
• Adjunctive Clindamycin Versus Linezolid for β-lactam Treated Patients With Invasive Group A Streptococcal InfectionsActive, not recruitingNCT06126263
• A Study of Doxycycline to Treat Chlamydial InfectionCompletedNCT05840159Phase 4
• Bevacizumab in Adults With Recurrent Respiratory Papillomatosis (RRP)Active, not recruitingNCT05797246Phase 2
• Community Dynamics of Malaria Transmission in Humans and Mosquitoes in Fleh-la and Marshansue, Salala District, Bong County, LiberiaActive, not recruitingNCT04704674
• Malaria Transmission in Humans and Mosquitoes at the Area of Sabou, Burkina FasoCompletedNCT04650815
• Trimethoprim-Sulfamethoxazole vs Levofloxacin as Targeted Therapy for Stenotrophomonas Maltophilia Infections: a Retrospective Cohort StudyCompletedNCT04639817
• Surveillance of Individuals Following SARS-CoV-2 InfectionCompletedNCT04383444
• Plasmodium and Other Parasites in Pregnant Women and Children Around Margibi and Montserrado Counties, LiberiaCompletedNCT03719599
• A Systems Biology Approach to Malaria ImmunityCompletedNCT03014258Phase 1
• Zika Virus and Related Arbovirus Infections in Deferred Blood Donors (ZVADD)CompletedNCT02794181
• Feasibility of Measuring Immune Resp, Activation in Foreskin/Mucosa in HIV-, Uncircumcised High-HIV-risk MSM, Lima PeruCompletedNCT02630082Not applicable
• Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 InfectionTerminatedNCT02527460Phase 1
• Collection of Plasma From People Who Recovered From or Were Vaccinated to Emerging Infectious DiseasesCompletedNCT02338986
• Human Immunity Against Staphylococcus Aureus Skin InfectionCompletedNCT02262819Phase 1
• Immune Responses to Mycobacterium Tuberculosis (Mtb) in People With Latent Tuberculosis Infection With or Without Concomitant Helminth InfectionTerminatedNCT02225158
• Navitoclax and Sorafenib Tosylate in Treating Patients With Relapsed or Refractory Solid TumorsCompletedNCT02143401Phase 1
• Erlotinib Hydrochloride in Treating Non-Small Cell Lung Cancer That is Metastatic or Cannot be Removed by Surgery in Patients With HIV InfectionTerminatedNCT02134886Phase 1
• Zoonotic Influenza Infections of Swine Origin at Ohio Agricultural FairsCompletedNCT02124096
• Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV InfectionTerminatedNCT02109224Phase 1
• VRC 601: A Phase I, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC HIVMAB060-00-AB (VRC01), With Broad HIV-1 Neutralizing Activity, Administered Intravenously or Subcutaneously to HIV-Infected...CompletedNCT01950325Phase 1
• Sildenafil for PNTM InfectionCompletedNCT01853540Phase 1/2
• Human Rhinovirus Infection and Airway Remodeling MediatorsTerminatedNCT01847768Not applicable
• Gene Expression in HIV and Tuberculosis Co-infectionCompletedNCT01611402
• Effect of Filarial Infection on Immune Responses in Latent TuberculosisCompletedNCT01547884
• Evaluating the Safety and Immune Response to Two Pneumococcal Vaccines in HIV-Infected Pregnant WomenWithdrawnNCT01443117Phase 2
• DAS181 in Patients With ParainfluenzaWithdrawnNCT01441024Phase 2
• Long-Term Study of Liver Disease in People With Hepatitis B and/or Hepatitis C With or Without HIV InfectionCompletedNCT01350648
• Cross-sectional Characterization of Idiopathic BronchiectasisCompletedNCT01264055
• Multiplex Microarray Chip-Based Diagnosis of Respiratory InfectionsTerminatedNCT01212042
• Evaluation of the Safety and Immunogenicity of a Live Attenuated Virus Vaccine for the Prevention of H2N3 InfluenzaCompletedNCT01175122Phase 1
• Evaluation of the Cellular Pharmacology of Tenofovir and Emtricitabine According to HIV Infection StatusCompletedNCT01040091Phase 1
• A Phase I Study of Mozobil in the Treatment of Patients With WHIMSCompletedNCT00967785Phase 1/2
• Longitudinal Studies of HIV-Associated Lung Infections and Complications (Lung HIV)CompletedNCT00933595Not applicable
• Early Molecular Detection for the Improved Diagnosis of Invasive Pulmonary Aspergillosis and Invasive Pulmonary ZygomycosisCompletedNCT00923832
• Host Factors in Invasive and Recurrent Staphylococcus Aureus InfectionTerminatedNCT00911430
• Physician Focused Intervention to Improve Adherence With HIV AntiretroviralsCompletedNCT00870792Not applicable
• Safety of Acidform Lubricant in HIV-Uninfected WomenCompletedNCT00850837Phase 1
• An Hepatitis B Vaccine Model for HIV Vaccine Trials in Drug UsersCompletedNCT00841477Phase 3
• Hepatitis B and HIV Co-Infection in Patients in UgandaCompletedNCT00782158
• Bone Mineral Density Substudy - An Ancillary Study to MTN-003CompletedNCT00729573
• Safety and Tolerability of a Therapeutic DNA Dendritic Cell Vaccine in HIV-Infected Children, Adolescents, and Young AdultsWithdrawnNCT00614640Phase 1/2