National Institutes of Health: Immunologic Deficiency Syndromes trials

The registry lists 106 Immunologic Deficiency Syndromes studies with National Institutes of Health as lead sponsor. 16 are open to participants now and 10 have results posted.

Early Phase 1 1Phase 1 22Phase 2 21Phase 3 6Phase 4 3No phase 59(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Base-Edited Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of CXCR4-WHIMEnrolling by invitationNCT07775313Phase 1/2
• Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without ThymectomyRecruitingNCT07416201
• Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated ColitisRecruitingNCT05333471Phase 1/2
• A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) SyndromeRecruitingNCT05027945Phase 2
• Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman DiseaseRecruitingNCT03300830
• Natural History of Noncirrhotic Portal HypertensionRecruitingNCT02417740
• Pathogenesis and Genetics of Disseminated or Refractory CoccidioidomycosisRecruitingNCT02190266
• Allogeneic Hematopoietic Stem Cell Transplant for GATA2 MutationsRecruitingNCT01861106Phase 2
• Apheresis of Patients With ImmunodeficiencyRecruitingNCT01212055
• Natural History Study of SCID DisordersEnrolling by invitationNCT01186913
• The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known ImmunocompromiseRecruitingNCT01011712
• Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ LymphocytopeniaRecruitingNCT00867269
• Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)RecruitingNCT00006150
• Genetic Analysis of Immune DisordersRecruitingNCT00001467
• Detection and Characterization of Host Defense DefectsRecruitingNCT00001355
• Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIVRecruitingNCT00001281
• Allogeneic Hematopoietic Stem Cell Transplantation With Briquilimab-Based Conditioning in Participants With GATA2 DeficiencyActive, not recruitingNCT05907746Phase 2Results posted
• A Clinical Trial to Evaluate the Safety and Immunogenicity of BG505 MD39.3, BG505 MD39.3 gp151, and BG505 MD39.3 gp151 CD4KO HIV Trimer mRNA Vaccines in Healthy, HIV-uninfected Adult ParticipantsActive, not recruitingNCT05217641Phase 1Results posted
• COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and DysregulationsCompletedNCT04852276Results posted
• Dose, Safety, Tolerability, and Immunogenicity of an HIV-1 Vaccine, VRC-HIVRGP096-00-VP, With Alum in Healthy AdultsCompletedNCT03783130Phase 1Results posted
• Plerixafor Versus G-CSF in the Treatment of People With WHIM SyndromeCompletedNCT02231879Phase 2/3Results posted
• Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous DiseaseTerminatedNCT01147042Phase 4Results posted
• Pilot and Feasibility Study of Reduced-Intensity Hematopoietic Stem Cell Transplant for MonoMACCompletedNCT00923364Phase 2Results posted
• Effect of Ranitidine on Hyper-IgE Recurrent Infection (Job's) SyndromeTerminatedNCT00527878Phase 2Results posted
• Treatment for Growth Failure in Patients With X-Linked Severe Combined Immunodeficiency: Phase 2 Study of Insulin-Like Growth Factor-1TerminatedNCT00490100Phase 1/2Results posted
• Donor Stem Cell Transplantation for Congenital ImmunodeficienciesCompletedNCT00426517Early Phase 1Results posted
• Sample Collection for Systems Evaluation of Patients With Unknown or Incompletely Characterized Immune DefectsCompletedNCT04408950
• Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined ImmunodeficiencyStatus unknownNCT03315078Phase 1/2
• Breadth of Donor Options for People With Inherited Diseases Requiring Allogeneic Hematopoietic Stem Cell Transplant in the Era of Alternative Donor Transplants Using Post-Transplantation CyclophosphamideCompletedNCT03188419
• Feasibility of Measuring Immune Resp, Activation in Foreskin/Mucosa in HIV-, Uncircumcised High-HIV-risk MSM, Lima PeruCompletedNCT02630082Not applicable
• Participation in a Research Registry for Immune DisordersCompletedNCT01953016
• Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 DeficiencyActive, not recruitingNCT01176006Phase 2
• A Phase I Study of Mozobil in the Treatment of Patients With WHIMSCompletedNCT00967785Phase 1/2
• Screening Protocol for Genetic Diseases of Allergic InflammationCompletedNCT00852943
• Relationship of Viral Resistance Development to CD4 Monitoring Alone or With Viral Load MonitoringCompletedNCT00434070
• Decision-Making of Hispanics and African-Americans With HIV/AIDS Participating in Clinical TrialsCompletedNCT00394004
• STA-5326 Meslylate to Treat Gut Inflammation Associated With Common Variable ImmunodeficiencyCompletedNCT00263237Phase 1
• Developing Newborn Screening for Infants With Primary ImmunodeficiencyCompletedNCT00113464
• Retrovirus Epidemiology Donor Study-II (REDS-II)CompletedNCT00097006
• Efficacy of Elevated CD4 Counts on CMV RetinitisCompletedNCT00091884
• Analysis of Immune Responses to HIV VaccinesCompletedNCT00068978
• Relaxation Response With Acupuncture for HIV PatientsCompletedNCT00064740Phase 2
• Computer-Assisted Adherence Program for Patients Taking Anti-HIV DrugsTerminatedNCT00051766Not applicable
• Treatment of Depression With Massage in HIVCompletedNCT00033852Phase 2
• Immune Restoration by Lipoic Acid in AIDSCompletedNCT00033176Phase 2
• The Use of Reiki for Patients With Advanced AIDSCompletedNCT00032721Phase 2
• Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID)CompletedNCT00028236Phase 1
• Antibody Production in Immune DisordersTerminatedNCT00023504Phase 4
• Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) DeficiencyCompletedNCT00018018Phase 1
• Immune System and Gut Abnormalities in Patients With Common Variable Immunodeficiency With and Without Gastrointestinal SymptomsCompletedNCT00015431
• Influences on Female Adolescents' Decisions Regarding Testing for Carrier Status of XSCIDCompletedNCT00006335
• Molecular and Clinical Studies of Primary Immunodeficiency DiseasesActive, not recruitingNCT00006319
• Randomized Study of Two Doses of Oral Valacyclovir in Immunocompromised Patients With Uncomplicated Herpes ZosterCompletedNCT00006131Not applicable
• HIV Diversity and Pathogenesis in Donor-Recipient ClustersCompletedNCT00005360
• Cardiac Autonomic Control in Children of HIV Positive MothersCompletedNCT00005353
• Effectiveness of AIDS Antibody ScreeningCompletedNCT00005303
• Transfusion Safety Study (TSS)CompletedNCT00005301
• Retrovirus Epidemiology Donor Study I (REDS I)CompletedNCT00005278
• Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2)CompletedNCT00005274
• Pulmonary Complications of HIV Infection Study (PACS)CompletedNCT00005273
• HIV-Associated Heart DiseaseCompletedNCT00005229
• AIDS-Associated Heart Disease -- Incidence and EtiologyCompletedNCT00005228
• AIDS-Associated CardiomyopathyCompletedNCT00005227
• Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus RetinitisCompletedNCT00004794Phase 2
• Randomized Placebo-Controlled Study of Aerobic Exercise and Resistance Training Plus Megestrol Acetate for HIV-WastingCompletedNCT00004664Not applicable
• Once-Daily Drug Regimen for HIV-Infected PatientsCompletedNCT00001968Phase 1
• Genetic Basis of Primary ImmunodeficienciesTerminatedNCT00001788
• Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex InfectionCompletedNCT00001763Phase 1
• A Pilot Study of Adherence to Oral Medication and Health Beliefs of Adolescents With HIV and Their MothersCompletedNCT00001699
• Use of Bromodeoxyuridine to Study White Blood Cell Replication and Survival in HIV-Infected PatientsCompletedNCT00001650
• White Blood Cell Infusions to Treat HIV InfectionCompletedNCT00001647Phase 1
• Voriconazole vs. Amphotericin B in the Treatment of Invasive AspergillosisCompletedNCT00001646Phase 3
• Immune Activity Against CVM RetinitisCompletedNCT00001611
• Clinical, Laboratory and Epidemiologic Pilot Studies of Individuals at High Risk for Viral-Associated CancersCompletedNCT00001560
• Fluconazole Prophylaxis of Thrush in AIDSCompletedNCT00001542Phase 4
• Phase I Study of APL 400-003, a Candidate HIV Vaccine, in HIV-Negative VolunteersCompletedNCT00001538Phase 1
• Twins Study of Gene Therapy for HIV InfectionCompletedNCT00001535Phase 1
• Thalidomide to Treat Oral Lesions in HIV-Infected PatientsCompletedNCT00001524Phase 2
• Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex TraitsCompletedNCT00001500
• Home Treatment of HIV-Infected Patients With Interleukin-2 With or Without a Tumor Necrosis Factor AntagonistCompletedNCT00001475Phase 2
• A Phase I /II Study of the Protease Inhibitor Indinavir (MK-0639) in Children With HIV InfectionCompletedNCT00001443Phase 1
• A Pilot Study of the Combination of Retinoic Acid and Interferon-Alpha2a for the Treatment of Lymphoproliferative Disorders in Children With Immunodeficiency SyndromesCompletedNCT00001438Phase 2
• Psychosocial Correlates and Coping Strategies Associated With Long-Term Survival of HIV-Infected ChildrenCompletedNCT00001435
• Evaluation and Natural History of Children With Cancer and AIDSCompletedNCT00001424
• Phase I Protocol for the Evaluation of the Safety and Immunogenicity of Vaccination With Synthetic HIV Envelope Peptides in Patients With Early Human Immunodeficiency Virus InfectionCompletedNCT00001386Phase 1
• Interleukin-2 Therapy for HIV Infection - Supplemental ProceduresCompletedNCT00001354Phase 2
• Safety and Survival of Genetically Modified White Blood Cells in HIV-Infected Persons - A Study in Identical Twin PairsCompletedNCT00001353
• In Vitro Studies of Immunological and Stem Cell Function in Peripheral Blood Mononuclear Cells in PatientsCompletedNCT00001336
• A Randomized Pilot Study for the Treatment of AIDS or AIDS Related Complex With an Alternating or Simultaneous Combination Regimen of AZT and 2',3'-DideoxyinosineCompletedNCT00001267Phase 3
• Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History StudyCompletedNCT00001255
• Studies of the Immune Response in Normal Subjects and Patients With Disorders of the Immune SystemCompletedNCT00001158
• Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Suspected Latent Tuberculous InfectionCompletedNCT00000959Not applicable
• A Placebo-Controlled, Phase I, Pilot Clinical Trial to Evaluate the Safety and Immunogenicity of ENV 2-3, a Yeast-Derived Recombinant Envelope Protein of Human Immunodeficiency Virus-1, in Combination With MTP-PE/MF59 in Individuals With HIV Infection (Placebo Patients Receive MF59 Emulsion Only)CompletedNCT00000958Phase 1
• Two-Stage Tuberculin (PPD) Skin Testing in Individuals With Human Immunodeficiency Virus (HIV) InfectionCompletedNCT00000955Not applicable
• Phase I Pharmacokinetic and Tolerance Study of Ribavirin in Human Immunodeficiency Virus (HIV) - Infected PatientsCompletedNCT00000733Phase 1
• Foscarnet Treatment of Serious CMV Retinitis Infection in Patients With Acquired Immunodeficiency SyndromeCompletedNCT00000726Phase 1
• A Phase I Evaluation of Azidothymidine (AZT) in Children With Acquired Immune Deficiency Syndrome (AIDS) or AIDS Related Complex (ARC)CompletedNCT00000701Phase 1
• A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCPCompletedNCT00000700Phase 3
• Continuous High-Dose Intravenous Dextran Sulfate in Human Immunodeficiency Virus-Infected IndividualsCompletedNCT00000684Not applicable
• A Phase I Multicenter, Randomized, Double-Blind Trial to Evaluate the Safety and Immunogenicity of Recombinant Vaccinia Virus Expressing the Envelope Glycoproteins of Human Immunodeficiency VirusCompletedNCT00000683Phase 1