National Institutes of Health: Depression trials

The registry lists 118 Depression studies with National Institutes of Health as lead sponsor. 12 are open to participants now and 19 have results posted.

Early Phase 1 1Phase 1 17Phase 2 30Phase 3 6Phase 4 10No phase 57(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Ecological Momentary Assessment of State-Dependent Decision-Making and Metacognition Across a Psychopathology ContinuumNot yet recruitingNCT07801079
• Longitudinal Deep Phenotyping of Central Mechanisms in Dysosmia: A Pilot Study Using Electrobulbogram (EBG), Functional MRI (fMRI), and Diffusion-Weighted Imaging (DWI)RecruitingNCT07149428
• Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionRecruitingNCT06511908Phase 2
• Natural History of Depression, Bipolar Disorder and Suicide RiskRecruitingNCT06462196
• [18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PETRecruitingNCT05703685Phase 1
• Long-term Observation of Participants With Mood DisordersRecruitingNCT04877977
• PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)RecruitingNCT04582916Phase 1
• Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionRecruitingNCT03973268Phase 1
• Characterization and Treatment of Adolescent DepressionRecruitingNCT03388606
• Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderRecruitingNCT03065335Phase 1
• Neurobiology of SuicideRecruitingNCT02543983Phase 2
• Evaluation of Patients With Mood and Anxiety Disorders and Healthy VolunteersRecruitingNCT00024635
• [11C]-(R)-Rolipram to Measure cAMP Signaling Before and After KetamineTerminatedNCT05522673Phase 1Results posted
• Managing Cancer and Living Meaningfully (CALM) Therapy in Individuals Diagnosed With a Primary Brain TumorCompletedNCT04852302Not applicableResults posted
• Antidepressant Effects of TS-161 in Treatment-Resistant DepressionTerminatedNCT04821271Phase 2Results posted
• Title: Evaluation of a Novel PET Radioligand for Phosphodiesterase-4D (PDE4D)CompletedNCT03861000Phase 1/2Results posted
• PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive SubjectsCompletedNCT03581305Phase 1Results posted
• Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive DisorderCompletedNCT02484456Phase 2Results posted
• Does Enhanced Glutamate Transporter Function Produce Antidepressant Effects in People With Major Depression?TerminatedNCT02049385Phase 1/2Results posted
• Combining Medications to Enhance Depression OutcomesCompletedNCT00590863Phase 4Results posted
• Antidepressant Effects of NR2B in Major DepressionCompletedNCT00472576Phase 1Results posted
• The Antidepressant Efficacy of the Anticholinergic ScopolamineTerminatedNCT00369915Phase 2Results posted
• Org 24448 to Treat Major DepressionTerminatedNCT00113022Phase 2Results posted
• The Effects of Smell on Mood and Physical ResponsesCompletedNCT00097253Phase 1Results posted
• Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral ContraceptivesTerminatedNCT00089414Phase 2Results posted
• Rapid Antidepressant Effects of Ketamine in Major DepressionCompletedNCT00088699Phase 1/2Results posted
• Lexapro and Pramipexole and to Treat Major DepressionCompletedNCT00086307Phase 2Results posted
• Rapid Antidepressant Effects of Yohimbine in Major DepressionCompletedNCT00078715Phase 2Results posted
• Electroacupuncture for Major DepressionCompletedNCT00071110Phase 2Results posted
• Clinical Trial of Estrogen for Postpartum DepressionTerminatedNCT00059228Phase 2Results posted
• Raloxifene and Rimostil for Perimenopause-Related DepressionCompletedNCT00030147Phase 4Results posted
• Mental Health Impact of the COVID-19 Pandemic on Amish and Mennonite Participants in AMBiGenCompletedNCT04684615
• An Investigation of the Biological and Neuronal Mechanisms of Post Traumatic Stress Disorder, Depression and Post-Concussive Syndrome Onset Following a Traumatic Brain InjuryCompletedNCT02019654
• Brain Inflammation in Major Depressive Disorder BackgroundCompletedNCT01851356
• A Pilot Study to Extend the K-SADS-PL to Adolescents and Young AdultsCompletedNCT01778478
• Brain Imaging, Genetics and Treatment for Major DepressionWithdrawnNCT01568684Phase 1
• Mood and Insulin Resistance in Adolescents At-Risk for DiabetesCompletedNCT01425905Phase 2
• A Prospective Study of Postpartum Depression in Women With Major DepressionTerminatedNCT01328613
• Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive DisorderWithdrawnNCT01313403Not applicable
• PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1ACompletedNCT01198197Early Phase 1
• PET Whole Body Distribution Studies Using [11C]CUMICompletedNCT01132872
• Depression Outcomes Study of ExerciseCompletedNCT00964054Phase 1
• GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major DepressionCompletedNCT00931619
• Fatigue in Healthy IndividualsCompletedNCT00888563
• p11 Protein Levels in Patients With Major Depressive Disorder Treated With CitalopramCompletedNCT00697268
• Cognitive Behavioral Treatment of Depression in ESRD Patients on DialysisCompletedNCT00618475Not applicable
• Improving Depression Treatment for Older Minority AdultsCompletedNCT00570427Not applicable
• Assessing Treatment Emergent Suicidal Ideation in Patients With Major DepressionCompletedNCT00532103
• Healthy Outcomes of Pregnancy EducationStatus unknownNCT00381823Phase 2
• Brain Activity Changes and Treatment Response in Depressed People Who Are Receiving Antidepressant MedicationCompletedNCT00375843Phase 4
• Preventing Depression Recurrence in DiabetesCompletedNCT00374426Phase 4
• Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed PatientsCompletedNCT00369798Phase 1
• Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar DisorderWithdrawnNCT00327756Phase 2
• Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research GroupCompletedNCT00265291Phase 2
• Epidemiology of Depression and Heart Failure in AgingCompletedNCT00241761
• Shingles: Immune Effects of Tai ChiCompletedNCT00118885Phase 2
• Parent Psychoeducation and Cognitive Behavior Therapy for Latino Adolescents With DepressionStatus unknownNCT00118469Phase 2
• Dopamine Receptor Imaging in Mood DisordersCompletedNCT00116077
• Hormonal Causes of Menstrual-Related Mood DisordersCompletedNCT00100360
• Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood DisordersCompletedNCT00097175
• Ethyl Eicosapentanoic Acid (Ethyl-EPA) for Treating Major DepressionCompletedNCT00096798Phase 3
• Yoga for Treating People at Risk for Diabetes or With Both HIV and DepressionCompletedNCT00090506Phase 1
• Neurocardiac Control in Major DepressionCompletedNCT00084162
• Dutasteride to Treat Women With Menstrually Related Mood DisordersCompletedNCT00082043Phase 1
• Function of Catecholamines in the Brain During DepressionCompletedNCT00082030
• FMRI Study of Performance During a Probabilistic Reversal Learning Task in DepressionCompletedNCT00075296
• Genetics of FibromyalgiaStatus unknownNCT00071162
• Evaluating Brain Responses to Facial Expressions in Major Depressive DisorderCompletedNCT00071123
• An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant DepressionCompletedNCT00070694Phase 2
• PUFA Augmentation in Treatment of Major DepressionCompletedNCT00067301Phase 3
• Spirituality, Religiosity, and Immune FunctioningCompletedNCT00066924
• The Psychobiology of Childhood TemperamentCompletedNCT00060775
• The Effects of Estrogen Withdrawal on Mood Symptoms in WomenCompletedNCT00060736
• Brain Regulation of Emotions in People With Depression and AnhedoniaCompletedNCT00059579
• Screening Evaluation for Women With Postpartum DepressionTerminatedNCT00056901
• Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging StudiesTerminatedNCT00055575Phase 2
• Brain Imaging in DepressionCompletedNCT00050700
• MRI Study of Brain Activity and Risk for Depression in AdolescentsCompletedNCT00047944
• Ethnic Variations in Antidepressant ResponseCompletedNCT00047671Phase 4
• Dyadic Interactions in Depressed and Non-Depressed Mothers and Their InfantsCompletedNCT00044174
• Examination of a Soy-Based Supplement for Major DepressionCompletedNCT00042380Phase 2
• Clinical Trial of Memantine for Major DepressionCompletedNCT00040261Phase 3
• Major Depression and Inflammatory Risk Markers for Coronary Heart DiseaseCompletedNCT00037505
• Clinical Trial of Felbamate for Treatment-Resistant Bipolar DepressionCompletedNCT00034229Phase 2
• Treatment of Depression With Massage in HIVCompletedNCT00033852Phase 2
• Serotonin Function During DepressionCompletedNCT00033787
• Evaluation of Clonazepam and Paroxetine for Panic Disorder With DepressionCompletedNCT00031317Phase 4
• The Treatment of Children and Adolescents With Treatment-Resistant DepressionCompletedNCT00029640
• Reward-Related Processes and Brain FunctionCompletedNCT00029588
• Magnetic Stimulation for Parkinson DiseaseCompletedNCT00029276Phase 1
• Examination of Brain Serotonin Receptors in Patients With Mood DisordersCompletedNCT00026832
• Riluzole to Treat Major DepressionCompletedNCT00026052Phase 2
• Sequenced Treatment Alternatives to Relieve Depression (STAR*D)CompletedNCT00021528Phase 4
• Factors Affecting Weight Gain in Women Receiving Adjuvant Chemotherapy for Breast CancerTerminatedNCT00019643
• Acupuncture in the Treatment of DepressionCompletedNCT00010517Phase 3
• Platelet Function in Patients Treated With SSRI and Non-SSRI AntidepressantsCompletedNCT00009568
• Treatment for Adolescents With Depression Study (TADS)CompletedNCT00006286Phase 3
• Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)CompletedNCT00006204Phase 4
• Bone Loss in Premenopausal Women With DepressionCompletedNCT00006180Phase 4
• Depression In Juvenile DiabeticsCompletedNCT00005116Not applicable