National Institutes of Health: Insulin Resistance trials

The registry lists 66 Insulin Resistance studies with National Institutes of Health as lead sponsor. 7 are open to participants now and 7 have results posted.

Phase 1 7Phase 2 18Phase 4 2No phase 41(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical TrialRecruitingNCT06274749Not applicable
• Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With ObesityNot yet recruitingNCT05713799Phase 2
• Study of Growth Hormone Inhibition Using Pegvisomant in Severe Insulin ResistanceRecruitingNCT05470504Phase 2
• Taste Bud-Derived Stem Cells in HumansRecruitingNCT03366168
• Type 1 Diabetes Extension StudyRecruitingNCT02734277
• Study of the Effect of Innate on the Inflammatory Response to EndotoxinRecruitingNCT01143480
• Genetic Studies of Insulin and DiabetesRecruitingNCT00001987
• Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study)CompletedNCT04216589Phase 2Results posted
• Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain FunctionCompletedNCT02460783Not applicableResults posted
• Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in People With Insulin Receptor MutationsCompletedNCT02457897Phase 2Results posted
• Myocardial Function & FFA Metabolism in HIV Metabolic SyndromeCompletedNCT00656851Not applicableResults posted
• Pioglitazone to Treat Fatty Liver in People With HIV InfectionCompletedNCT00441272Phase 2Results posted
• The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy VolunteersCompletedNCT00339833Phase 4Results posted
• Effect of Metreleptin Therapy in the Treatment of Severe Insulin ResistanceActive, not recruitingNCT00085982Phase 2Results posted
• Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With ObesityCompletedNCT05017571Phase 2
• Effect of Isocaloric Ultra Processed Versus Unprocessed Diets on Insulin SensitivityCompletedNCT03189121
• Pilot Study of Strength Testing in Overweight Women With or Without Insulin ResistanceCompletedNCT01862757
• Identifying Risk for Diabetes and Heart Disease in WomenCompletedNCT01809288
• The Role of Endocannabinoids in Insulin Production and ActionCompletedNCT01517100Phase 1
• Mood and Insulin Resistance in Adolescents At-Risk for DiabetesCompletedNCT01425905Phase 2
• Glucose and Lipid Metabolism in AdolescentsStatus unknownNCT00998855
• Metabolic Effects of Steroids in Obese MenStatus unknownNCT00983554Not applicable
• Age, Lifestyle, Muscle Mechanisms in Insulin ResistanceCompletedNCT00971594Not applicable
• Human Atherosclerotic Plaque Inflammation Imaged Using PDG-PET/CTCompletedNCT00958815
• An Exercise Intervention Study in Insulin-Resistant AdolescentsStatus unknownNCT00906724
• Race, Menopause and Metabolism After Exercise and DietCompletedNCT00882141Not applicable
• Metabolic Syndrome in an Elderly Population is More Linked to Insulin Resistance Than to ObesityStatus unknownNCT00873964
• DHA Supplements to Improve Insulin Sensitivity in Obese Pregnant Women (The Omega-3 Pregnancy Study)Status unknownNCT00865683Phase 1
• Pilot Study of Mitochondrial Biology in Human PlateletsCompletedNCT00833846
• Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese WomenCompletedNCT00666172Phase 2
• Insulin Resistance and Atherosclerosis in Women With LupusCompletedNCT00544102
• Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and ZidovudineCompletedNCT00471614Phase 2
• Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH MenCompletedNCT00470990Not applicable
• Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes MellitusCompletedNCT00445627
• Insulin Sensitivity in Men With the Metabolic SyndromeSuspendedNCT00433173Not applicable
• Substrate Cycling in Energy MetabolismCompletedNCT00361751Phase 2
• Exercise in Insulin-Resistant Minority AdolescentsCompletedNCT00345436
• Fat Cell Size in Insulin ResistanceCompletedNCT00341406
• Cross-Sectional and Longitudinal Studies of "Pre-Diabetes" in the Pima IndiansCompletedNCT00340132
• Insulin Resistance and Breast CancerCompletedNCT00304941
• Insulin Resistance in Severely Obese PatientsCompletedNCT00275223
• Acipimox to Improve Hyperlipidemia and Insulin Sensitivity Associated With HIVCompletedNCT00246402Not applicable
• Insulin Resistance and Central Nervous System (CNS) Function in Type 2 DiabetesCompletedNCT00212290Phase 4
• Peripheral Effects of Exercise on Cardiovascular Health (STRRIDE I)CompletedNCT00200993Phase 2
• Chromium Picolinate for the Treatment of Metabolic SyndromeCompletedNCT00128154Not applicable
• Use of a Nutritional Supplement to Treat Diabetic Symptoms in HIV-Infected AdultsCompletedNCT00109746Phase 1/2
• The Medical College of Georgia PLAY Project: Exercise Dose and Insulin Sensitivity in Obese ChildrenCompletedNCT00108901Phase 2
• Biologic Effects of Dehydroepiandrosterone (DHEA) in HumansCompletedNCT00099697Not applicable
• Effects of Dark Chocolate on Insulin Sensitivity in People With High Blood PressureCompletedNCT00099476Phase 1
• Rosiglitazone to Reverse Metabolic Defects in DiabetesCompletedNCT00094796Phase 2
• Genomewide Search for Loci Underlying Metabolic SyndromeCompletedNCT00074451
• Insulin Resistance and Insulin SecretionWithdrawnNCT00073294Not applicable
• Effects of Oral Glucosamine on Insulin and Blood Vessel Activity in Normal and Obese PeopleCompletedNCT00065377Phase 1
• VA HDL Intervention Trial (VA-HIT) Ancillary Study Data AnalysisCompletedNCT00035711
• Ginkgo Biloba Extract and the Insulin Resistance SyndromeCompletedNCT00032474Phase 1/2
• Leptin to Treat Severe Insulin Resistance - Pilot StudyCompletedNCT00027456Phase 2
• Rosiglitazone and Exercise Training: Effects on HIV-Infected People With Insulin Resistance, Hypertriglyceridemia, and Adipose Tissue MaldistributionCompletedNCT00025753Not applicable
• Prenatal Nutrition and Adult DiseaseCompletedNCT00024583
• A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes)CompletedNCT00015626Phase 2
• Underlying Abnormalities in Fat and Muscle Leading to Lipodystrophy SyndromeCompletedNCT00006185Phase 1
• Lipoprotein Metabolism in Hypertensive African-AmericansCompletedNCT00005709
• Insulin, Androgen, and Risk in African-American WomenCompletedNCT00005380
• Insulin and Biogenic Amines in Cardiovascular DiseaseCompletedNCT00005194
• Insulin Resistance and Blood Pressure Regulation in BlacksCompletedNCT00005164
• Insulin Resistance Atherosclerosis Study (IRAS)CompletedNCT00005135
• Methods for Measuring Insulin SensitivityCompletedNCT00001625