National Institutes of Health: Autoimmune Diseases trials

The registry lists 47 Autoimmune Diseases studies with National Institutes of Health as lead sponsor. 16 are open to participants now and 9 have results posted.

Early Phase 1 1Phase 1 8Phase 2 13Phase 3 3Phase 4 1No phase 24(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Ublituximab in Autoantibody Positive Immune Mediated Necrotizing MyopathyRecruitingNCT07103746Phase 2
• Deciphering the Genetic Architecture of Autoimmune DiseasesRecruitingNCT06948110
• Daratumumab in Primary Antiphospholipid SyndromeRecruitingNCT05671757Phase 1/2
• A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) SyndromeRecruitingNCT05027945Phase 2
• Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of ImmunityRecruitingNCT04339777Phase 2
• Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)RecruitingNCT04304820Phase 2Results posted
• Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)RecruitingNCT04097561Phase 1
• Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVORecruitingNCT03816345Phase 1
• NIAID Centralized Sequencing ProtocolRecruitingNCT03206099
• Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary ImmunodeficienciesRecruitingNCT02579967Phase 2
• Environmental Risk Factors for the Anti-synthetase SyndromeRecruitingNCT01276470
• Rituximab Plus Cyclosporine in Idiopathic Membranous NephropathyRecruitingNCT00977977Phase 2
• Natural History of BronchiectasisRecruitingNCT00943514
• Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ LymphocytopeniaRecruitingNCT00867269
• Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell DeathRecruitingNCT00246857
• Study of Autoimmune Lymphoproliferative Syndrome (ALPS)RecruitingNCT00001350
• COVID-19 Booster Vaccine in Autoimmune Disease Non-RespondersTerminatedNCT05000216Phase 2Results posted
• Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or DysregulationActive, not recruitingNCT03663933Phase 2Results posted
• Aerobic Exercise in Women With Systemic Lupus ErythematosusTerminatedNCT03186794Not applicableResults posted
• Eltrombopag With Standard Immunosuppression for Severe Aplastic AnemiaActive, not recruitingNCT01623167Phase 1/2Results posted
• A Study to Determine the Immunogenicity and Oral Tolerance to Keyhole Limpet Hemocyanin (KLH)TerminatedNCT01489956Early Phase 1Results posted
• Eltrombopag for Moderate Aplastic AnemiaCompletedNCT01328587Phase 2Results posted
• Intravenous Immunoglobulin for PANDASCompletedNCT01281969Phase 3Results posted
• Scleroderma: Cyclophosphamide or TransplantationCompletedNCT00114530Phase 2/3Results posted
• Natural History and Pathogenesis of Alopecia in Children and AdultsCompletedNCT05502796
• Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell LymphomaActive, not recruitingNCT03922724Phase 2
• Chronic Graft-versus-Host Disease in the Oral Cavity of Patients Following Allogeneic Hematopoietic Stem Cell Transplant and Including Healthy ControlsCompletedNCT03602599
• T and B Cell Responses in Autoimmune DiseasesTerminatedNCT01947036
• Agricultural Health Study Follow-upCompletedNCT01399411
• Collection of Blood, Bone Marrow, Leukapheresis, and Tissue Biopsy Samples From Patients and Their Family Members for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases Laboratory Research StudiesTerminatedNCT01200823
• Rituximab for Autoimmune RetinopathyCompletedNCT01086631Phase 1
• Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research StudiesCompletedNCT00995891
• Screening Protocol for Subjects Being Evaluated for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) ProtocolsCompletedNCT00968084
• Screening Protocol for Genetic Diseases of Allergic InflammationCompletedNCT00852943
• Studies of the Natural History and Pathogenesis of Autoimmune/Connective Tissue DiseasesCompletedNCT00341679
• Confirmation of Systemic Autoimmune Diseases in the Agricultural Health StudyCompletedNCT00341198
• Continuation of Follow-up of DES-Exposed CohortsCompletedNCT00340600
• Pyrimethamine to Treat Autoimmune Lymphoproliferative SyndromeCompletedNCT00065390Phase 1
• Study of Oral Bacteria in Patients With Dry MouthCompletedNCT00048685
• Treatment of Multiple Sclerosis With Copaxone and AlbuterolCompletedNCT00039988Not applicable
• Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative SyndromeCompletedNCT00013689Phase 1
• Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)CompletedNCT00001768Phase 3
• Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal InfectionsCompletedNCT00001658Phase 4
• Treatment of Autoimmune Thrombocytopenia (AITP)CompletedNCT00001630Phase 1
• Study of Silicone-Associated Connective Tissue DiseasesCompletedNCT00001330
• Steroid Therapy in Autoimmune Premature Ovarian FailureCompletedNCT00001306
• Genetic and Immune Studies of Rheumatoid Arthritis and Related ConditionsCompletedNCT00001291