National Institutes of Health: Hypertension trials

The registry lists 102 Hypertension studies with National Institutes of Health as lead sponsor. 4 are open to participants now and 3 have results posted.

Early Phase 1 1Phase 1 13Phase 2 17Phase 3 12Phase 4 3No phase 59(a study in two phases counts in both)

Studies

Page 1 of 2. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Childhood-Onset Essential Hypertension Natural History StudyRecruitingNCT06778239
• Clinical and Molecular Characteristics of Primary Aldosteronism in BlacksRecruitingNCT03374215
• Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ ParagangliomaRecruitingNCT03206060Phase 2
• Diabetes and Heart Disease Risk in BlacksRecruitingNCT00001853
• Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)CompletedNCT01086540Phase 2Results posted
• Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell DiseaseTerminatedNCT00492531Phase 2Results posted
• Breathe: Slow Paced Breathing to Lower Blood PressureCompletedNCT00328016Not applicableResults posted
• Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype StudyWithdrawnNCT05548881
• African American Study of Kidney Disease and HypertensionCompletedNCT04364139Phase 3
• Phosphodiesterase Type-5 Inhibitor Therapy in Sickle Cell People With Pulmonary HypertensionCompletedNCT03572036
• WS-SAVE Study (Williams Syndrome Skin and Vessel Elasticity Study)CompletedNCT02692846
• Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0CompletedNCT02290392
• Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)CompletedNCT02055209
• Hydroxyurea in Pulmonary Arterial HypertensionWithdrawnNCT01950585Early Phase 1
• Resveratrol and Cardiovascular Health in the ElderlyTerminatedNCT01842399Phase 1/2
• Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell DiseaseWithdrawnNCT01568645Phase 1
• Effects of Lifeskills Workshop on BP in Hypertensive EmployeesCompletedNCT01262066Phase 2
• Mechanisms of the Relaxation Response in Elderly HypertensivesCompletedNCT00913991Phase 1
• Genetics of Type 2 Diabetes in West AfricansCompletedNCT00837122
• Sodium Nitroprusside for Blood Pressure Reduction in the ICU (SNP2)CompletedNCT00621816Phase 2
• African American Study of Kidney Disease and Hypertension ABPM Pilot StudyCompletedNCT00582777Phase 2/3
• Role of Nitric Oxide in MalariaCompletedNCT00527163
• Pulmonary Hypertension, Hypoxia and Sickle Cell DiseaseCompletedNCT00495638
• Magnetic Resonance Angiography to Diagnose Atherosclerotic DiseaseCompletedNCT00382564
• Pulmonary Hypertension in Patients With Sickle Cell Disease in NigeriaCompletedNCT00367523
• Genetic Analysis of African-Americans With High Blood PressureCompletedNCT00353925
• Sildenafil to Increase Exercise Capacity in Individuals With Idiopathic Pulmonary Fibrosis and Pulmonary HypertensionCompletedNCT00352482Phase 2
• Cardiopulmonary Function Assessment and NO-Based Therapies for Patients With Hemolysis-Associated Pulmonary HypertensionCompletedNCT00352430Phase 1
• Sildenafil to Treat HIV-Associated Pulmonary HypertensionTerminatedNCT00327080Phase 1
• Uric Acid in Essential Hypertension in ChildrenCompletedNCT00288184Phase 2
• Allopurinol for Renal Transplant Associated Hypertension in ChildrenWithdrawnNCT00288171Phase 1/2
• Primary Prevention of Hypertension in Obese AdolescentsCompletedNCT00288158Phase 2
• Hydroxyurea and Erythropoietin to Treat Sickle Cell AnemiaCompletedNCT00270478Phase 1
• Conditioned Placebo Effects and Treatment of HypertensionCompletedNCT00269269Phase 2
• Guideline Adherence for Heart HealthCompletedNCT00224848Phase 2
• Exercise Training in Type 2 Diabetes and HypertensionCompletedNCT00212303Phase 4
• Adherence to Weight Loss for Hypertension in African American WomenCompletedNCT00142649Not applicable
• Patient-Physician Partnership to Improve High Blood Pressure AdherenceCompletedNCT00123045Phase 4
• Heart Disease in Sickle Cell AnemiaCompletedNCT00113152
• Hypertension Education and Treatment Partnership for Reducing Ethnic Differences in the Risk of Cardiovascular DiseaseCompletedNCT00101504
• Effects of Dark Chocolate on Insulin Sensitivity in People With High Blood PressureCompletedNCT00099476Phase 1
• Endothelial Cell Dysfunction in Pulmonary HypertensionCompletedNCT00098072Phase 1
• HYPGENE-Genetics Fitness Obesity & Risk of HypertensionCompletedNCT00083811
• Women's Use of Alternative Medicine: A Multiethnic StudyCompletedNCT00067249
• Hypertension: Prediction of Biofeedback SuccessCompletedNCT00026065Phase 1
• Nitric Oxide and Transfusion Therapy for Sickle Cell Patients With Pulmonary HypertensionCompletedNCT00023296Phase 1
• Acupuncture and HypertensionCompletedNCT00010478Not applicable
• Genetics of Hypertension and Its Intermediate PhenotypesCompletedNCT00006499
• Prevention of Esophageal Varices by Beta-Adrenergic BlockersCompletedNCT00006398Phase 3
• Magnetic Resonance Imaging for Evaluating Kidney FunctionCompletedNCT00006173
• Effects of Rosiglitazone on Blood Vessels in Patients With High Blood Pressure and High CholesterolCompletedNCT00006071
• Stress Reduction and Prevention of Hypertension in BlacksCompletedNCT00005748
• Improving Adherence to Interventions for HypertensionCompletedNCT00005708
• Urban African-American Community Hypertension ControlCompletedNCT00005706
• IN CONTROL--Hypertension Reduction in Inner City SeattleCompletedNCT00005698
• Blood Pressure Control--Racial and Psychosocial InfluencesCompletedNCT00005685
• Multi-Ethnic Study of Atherosclerosis (MESA)Active, not recruitingNCT00005487
• The Jackson Heart Study of Cardiovascular Disease Among African AmericansActive, not recruitingNCT00005485
• Job Strain, Ambulatory Blood Pressure and HypertensionCompletedNCT00005472
• Divergence of Blood Pressure By Race in Adolescent GirlsCompletedNCT00005470
• Maturational Changes in Cardiac Structures -- Blood Pressure Relationship -- SCOR in HypertensionCompletedNCT00005469
• Hypertensive and Normal Pregnancy--Calcium Metabolism and Renin-Angiotensin - SCOR in HypertensionCompletedNCT00005456
• Hypertension in Families of African OriginCompletedNCT00005444
• Opioid Compromise in Hypertension--Modulating FactorsCompletedNCT00005434
• Familial Aggregation of Stress ResponseCompletedNCT00005428
• Diagnosis/Pathophysiology of Glucocorticoid Remediable Aldosteronism HypertensionCompletedNCT00005394
• Genetics of Hypertension in BlacksCompletedNCT00005387
• Hypertension in Blacks of West African OriginCompletedNCT00005340
• Epidemic Hypertension in Nigerian WorkersCompletedNCT00005333
• White Coat Hypertension and Antihypertensive Treatment Effect - SCOR in HypertensionCompletedNCT00005316
• Hypertension in Minorities Database-Workshop and PublicationCompletedNCT00005311
• Regulation of Placental Vascular Reactivity in Pregnancy-induced HypertensionCompletedNCT00005208
• End-organ Pathology in Childhood Essential HypertensionCompletedNCT00005180
• Socioeconomic Status, John Henryism and Hypertension Risk in BlacksCompletedNCT00005172
• Sodium Transport: Genetics and HypertensionCompletedNCT00005166
• Segregation/Linkage Analysis for HypertensionCompletedNCT00005158
• Cardiovascular Health Study (CHS)Active, not recruitingNCT00005133
• Coronary Artery Risk Development in Young AdultsActive, not recruitingNCT00005130
• Study of the Effect of Four Methods of Cardiopulmonary Resuscitation Instruction on Psychosocial Response of Parents With Infants at Risk of Sudden DeathCompletedNCT00004805Not applicable
• Phase II Study of Lactulose and Circadian Rhythms in Patients With CirrhosisCompletedNCT00004796Phase 2
• Phase IV Study of Chronic Infusional Epoprostenol for Severe Primary Pulmonary HypertensionCompletedNCT00004754Phase 4
• Treatment of Hypertension With Two Exercise IntensitiesCompletedNCT00004561Phase 3
• The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic PatientsCompletedNCT00001742
• Methods for Measuring Insulin SensitivityCompletedNCT00001625
• Study of the Response of Human Small Blood VesselsCompletedNCT00001622Phase 1
• Role of Endothelin in the Regulation of Vascular Tone in Patients With Essential HypertensionCompletedNCT00001527
• Potential Risk Factors for StrokeCompletedNCT00001368Phase 1
• Study of Norepinephrine Levels and Sympathetic Nervous System ActivityCompletedNCT00001329
• Effects of Salt Intake on the Nervous Systems of Patients With Salt-Sensitive High Blood PressureCompletedNCT00001176
• Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and LensCompletedNCT00001161
• Pigment Dispersion Syndrome With and Without GlaucomaCompletedNCT00001152
• Dietary Approaches to Stop Hypertension (DASH)CompletedNCT00000544Phase 3
• Oral Calcium in Pregnant Women With HypertensionCompletedNCT00000543Phase 2
• Trial of Nonpharmacologic Interventions in Elderly (TONE)CompletedNCT00000535Phase 3
• Trials of Hypertension Prevention (TOHP)CompletedNCT00000528Phase 3
• Systolic Hypertension in the Elderly Program (SHEP)CompletedNCT00000514Phase 3
• Hypertension Prevention Trial (HPT) Feasibility StudyCompletedNCT00000501Phase 2
• Systolic Hypertension in the Elderly Program (SHEP) (Pilot Study)CompletedNCT00000499Phase 2
• Control of Hypertension by Non-Pharmacologic MeansCompletedNCT00000498Phase 3
• Hypertension Detection and Follow-up Program (HDFP)CompletedNCT00000485Phase 3