National Institutes of Health: Mood Disorders trials

The registry lists 43 Mood Disorders studies with National Institutes of Health as lead sponsor. 6 are open to participants now and 3 have results posted.

Phase 1 3Phase 2 14No phase 28(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionRecruitingNCT06511908Phase 2
• NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar DisorderRecruitingNCT05669703
• Characterization and Treatment of Adolescent DepressionRecruitingNCT03388606
• Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety DisordersRecruitingNCT00397111
• Studies of Brain Function and Course of Illness in Pediatric Bipolar DisorderRecruitingNCT00025935
• Evaluation of Patients With Mood and Anxiety Disorders and Healthy VolunteersRecruitingNCT00024635
• Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar DisorderTerminatedNCT00805493Phase 2Results posted
• A Controlled Trial of Serotonin Reuptake Inhibitors Added to Stimulant Medication in Youth With Severe Mood DysregulationCompletedNCT00794040Phase 2Results posted
• Rapid Antidepressant Effects of Ketamine in Major DepressionCompletedNCT00088699Phase 1/2Results posted
• Mental Health Impact of the COVID-19 Pandemic on Amish and Mennonite Participants in AMBiGenCompletedNCT04684615
• Mental Health Impact of COVID-19 Pandemic on NIMH Research Participants and VolunteersCompletedNCT04339790
• A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective DisorderCompletedNCT00593099Phase 1/2
• Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar DisorderWithdrawnNCT00327756Phase 2
• Identifying the Role of Oxytocin and Vasopressin in the Functioning of Neurocognitive Systems Involved in Mood DisordersCompletedNCT00325065
• Integrated Treatment for Cocaine and Mood Disorders - 1CompletedNCT00227812Phase 2
• Effectiveness of Divalproex Sodium (Depakote) in Treating Children With Temper Outbursts and Severe Mood SwingsCompletedNCT00217932Phase 2
• Dopamine Receptor Imaging in Mood DisordersCompletedNCT00116077
• Hormonal Causes of Menstrual-Related Mood DisordersCompletedNCT00100360
• Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood DisordersCompletedNCT00097175
• Dutasteride to Treat Women With Menstrually Related Mood DisordersCompletedNCT00082043Phase 1
• Family Study of Affective and Anxiety Spectrum DisordersCompletedNCT00071786
• Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging StudiesTerminatedNCT00055575Phase 2
• Examination of Brain Serotonin Receptors in Patients With Mood DisordersCompletedNCT00026832
• Adolescence, Puberty, and Emotion RegulationCompletedNCT00016731
• Clinical Trial of Propranolol for Seasonal Affective DisorderCompletedNCT00016666Phase 2
• Child & Adolescent Bipolar Disorder Brain Imaging and Treatment StudyCompletedNCT00006177
• Neuroimaging of St. John's Wort-Induced Changes of Serotonin Metabolism in Normal SubjectsCompletedNCT00001919
• Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety)CompletedNCT00001770
• The Role of Emotion in the Development of PsychopathologyCompletedNCT00001654
• Evaluation of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Mood DisordersCompletedNCT00001545Phase 2
• Treatment of Mid-Life-Related Mood DisordersCompletedNCT00001487Phase 2
• Effects of Season on Melatonin Secretion in Healthy Men and Women and Patients With Seasonal Affective DisorderCompletedNCT00001485
• New Drugs in the Treatment of Mood DisordersCompletedNCT00001482Phase 2
• Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major DepressionCompletedNCT00001479
• Effects of Drugs on Cerebral Blood Flow in Patients With Mood DisordersCompletedNCT00001478
• The Effect of GnRH on Pitutitary Hormones in Menstrual-Cycle Mood Related DisordersCompletedNCT00001232
• Perimenopause-Related Mood and Behavioral DisordersCompletedNCT00001231
• Neuropsychological Evaluation of Psychiatric and Neurological PatientsCompletedNCT00001192
• Study of Premenstrual Syndrome and Premenstrual DysphoriaCompletedNCT00001177
• Evaluation of the Genetics of Bipolar DisorderCompletedNCT00001174
• Study of the Psychological Development of Children of Parents With and Without Affective DisordersCompletedNCT00001170
• Omega-3 Fatty Acids in the Treatment of Bipolar Disorder: A Double-Blind, Placebo-Controlled TrialCompletedNCT00001146Phase 2
• The Effects of Sex Hormones on Cognition and Mood in Older AdultsTerminatedNCT00000175Not applicable