National Institutes of Health: Amyotrophic Lateral Sclerosis trials

The registry lists 21 Amyotrophic Lateral Sclerosis studies with National Institutes of Health as lead sponsor. 2 are open to participants now and 1 have results posted.

Phase 1 3Phase 2 5Phase 3 1No phase 13(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)RecruitingNCT07204977Phase 1
• Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal DementiaRecruitingNCT03225144
• HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)CompletedNCT02437110Phase 1Results posted
• Study of Hepatic Function in Patients With Spinal and Bulbar Muscular AtrophyCompletedNCT02124057
• Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene MutationCompletedNCT01925196
• Effect of Functional Exercise in Patients With Spinal Bulbar Muscular AtrophyCompletedNCT01369901Phase 1/2
• Confirmation of Self-Reported Incident ALS Cases in the AARP-Diet and Health (AARP-DH) CohortCompletedNCT00377351
• Collection of Blood Samples for DNA in Motor Neuron DiseaseCompletedNCT00362362
• Exposure to Neurotoxins as Risk Factors for Amyotrophic Lateral SclerosisCompletedNCT00339976
• Brain Function in Primary Lateral Sclerosis and Amyotrophic Lateral SclerosisCompletedNCT00334516
• Brain Function in Primary Lateral SclerosisCompletedNCT00071435
• Creatine for the Treatment of Amyotrophic Lateral SclerosisCompletedNCT00070993Phase 2
• Minocycline to Treat Amyotrophic Lateral SclerosisCompletedNCT00047723Phase 3
• Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral SclerosisCompletedNCT00023075
• Exogenous Toxicants and Genetic Susceptibility in ALSCompletedNCT00011154
• Clinical Trial of Creatine in Amyotrophic Lateral SclerosisCompletedNCT00005766Phase 2
• Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS]CompletedNCT00005674Phase 2
• Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron DiseaseCompletedNCT00004771Phase 2
• Determinants of Disease Severity in Amyotrophic Lateral SclerosisStatus unknownNCT00004457
• Magnetic Stimulation of the Human Nervous SystemCompletedNCT00001780
• Ultrasound and Videofluoroscopy for Diagnosing Swallowing DisordersCompletedNCT00001220