National Institutes of Health: Primary Immunodeficiency Diseases trials

The registry lists 18 Primary Immunodeficiency Diseases studies with National Institutes of Health as lead sponsor. 11 are open to participants now and 1 have results posted.

Phase 1 2Phase 2 1Phase 4 1No phase 15(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Detection and Characterization of Neurologic Manifestations of Inborn and Acquired Errors of ImmunityRecruitingNCT06169150
• NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)RecruitingNCT05189925Phase 1
• Metabolic Profiling of Immune Responses in Immune-mediated DiseasesRecruitingNCT04864886
• Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary ImmunodeficienciesRecruitingNCT03610802
• The Mechanistic Biology of Primary Immunodeficiency DisordersRecruitingNCT03394053
• NIAID Centralized Sequencing ProtocolRecruitingNCT03206099
• Studies of Disorders With Increased Susceptibility to Fungal InfectionsRecruitingNCT01222741
• Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation DisordersEnrolling by invitationNCT00895271
• Detection and Characterization of Infections and Infection SusceptibilityRecruitingNCT00404560
• Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell DeathRecruitingNCT00246857
• Genetic Analysis of Immune DisordersRecruitingNCT00001467
• Bilateral Orthotopic Lung Transplant - Bone Marrow TransplantCompletedNCT03330795Phase 1/2Results posted
• Participation in a Research Registry for Immune DisordersCompletedNCT01953016
• Studies of Disorders in Antibody Production and Related Primary Immunodeficiency StatesTerminatedNCT00266513
• Developing Newborn Screening for Infants With Primary ImmunodeficiencyCompletedNCT00113464
• Antibody Production in Immune DisordersTerminatedNCT00023504Phase 4
• Molecular and Clinical Studies of Primary Immunodeficiency DiseasesActive, not recruitingNCT00006319
• Genetic Basis of Primary ImmunodeficienciesTerminatedNCT00001788