National Institutes of Health: Hepatitis C trials

The registry lists 87 Hepatitis C studies with National Institutes of Health as lead sponsor. 2 are open to participants now and 27 have results posted.

Phase 1 16Phase 2 32Phase 3 9Phase 4 8No phase 30(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Study of the Pharmacokinetics and Safety of Glecaprevir/Pibrentasvir Initiated in Pregnancy in Women With Hepatitis C With and Without HIVRecruitingNCT07040319Phase 1/2
• Evaluation of Patients With Liver DiseaseRecruitingNCT00001971
• Viral Kinetics, Interferon Stimulated Genes (ISGs) and mirRNA Among Subjects Infected With Different Hepatitis C Virus Genotypes During Therapy With Sofosbuvir and GS-5816CompletedNCT02468648Phase 2Results posted
• Community-based Treatment of Chronic Hepatitis C Monoinfection and Coinfection With HIV in the District of ColumbiaCompletedNCT02339038Phase 4Results posted
• Evaluating the Safety and Effectiveness of Interferon-Free Treatment of Hepatitis C Virus Infection in HIV-Coinfected Adults on Antiretroviral TherapyTerminatedNCT02194998Phase 2Results posted
• Evaluation of Safety, Tolerability, and Antiviral Activity of Chlorcyclizine HCl in Patients With Chronic Hepatitis CCompletedNCT02118012Phase 1/2Results posted
• New Treatment Response in People With and Without Cirrhosis From Chronic Hepatitis CCompletedNCT01888900Phase 2Results posted
• Study of A Combination Pill With GS-7977 and GS-5885 for Hepatitis C in People With HIVCompletedNCT01878799Phase 2Results posted
• Combination Therapy for Chronic Hepatitis C InfectionCompletedNCT01805882Phase 2Results posted
• Evaluating the Effectiveness of Boceprevir, Pegylated-Interferon Alfa 2b and Ribavirin in Treating Hepatitis C Virus (HCV) Infection in Adults With HIV and HCV InfectionCompletedNCT01482767Phase 3Results posted
• GS-7977 With Ribavirin for Hepatitis C (SPARE)CompletedNCT01441180Phase 1/2Results posted
• Staged Phase I/II Hepatitis C Prophylactic VaccineCompletedNCT01436357Phase 1/2Results posted
• A Safety and Tolerability Study of Nitazoxanide in HIV-HCV Treatment FailuresCompletedNCT01185028Phase 1/2Results posted
• Open Label Study to Evaluate Chronic Hepatitis C Treatment in Latino Subjects With and Without HIV Co-infectionTerminatedNCT01182298Results posted
• Nitazoxanide Plus Ribavirin and Peginterferon for Therapy of Treatment Naive HCV Genotype 1 and HIV Coinfected SubjectsCompletedNCT00991289Phase 2Results posted
• Pioglitazone to Treat Fatty Liver in Patients With HIV and Hepatitis C InfectionsTerminatedNCT00742326Phase 4Results posted
• High-Dose Ribavirin and Peginterferon to Treat Chronic Hepatitis C Genotype 1CompletedNCT00735969Phase 2Results posted
• S-Adenosyl Methionine (SAMe) to Treat Patients With Chronic Hepatitis CCompletedNCT00475176Phase 2Results posted
• Anti-D for Treating Thrombocytopenia in Adults Infected With Hepatitis C Virus With or Without HIV Co-InfectionTerminatedNCT00239733Phase 4Results posted
• Pre-Transplant Treatment to Prevent Recurrence of Hepatitis C After Liver TransplantationCompletedNCT00135798Phase 2Results posted
• Gradual Withdrawal of Immune System Suppressing Drugs in Patients Receiving a Liver TransplantCompletedNCT00135694Phase 2Results posted
• PEDS-C: Pegylated Interferon +/- Ribavirin for Children With Hepatitis CCompletedNCT00100659Phase 3Results posted
• Peginterferon Alpha-2a and Ribavirin to Treat Hepatitis C in HIV-infected PatientsCompletedNCT00085917Phase 2Results posted
• Pegylated Interferon Alfa-2a Maintenance Therapy and Liver Disease Progression in People Infected With Both HIV and Hepatitis C Virus (HCV)CompletedNCT00078403Phase 2Results posted
• Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3CompletedNCT00056862Phase 4Results posted
• Rituximab to Treat Hepatitis C-Associated Cryoglobulinemic VasculitisCompletedNCT00029107Phase 2Results posted
• Pegylated Interferon and Ribavirin to Treat Chronic Hepatitis C With and Without Kidney DiseaseCompletedNCT00028093Phase 4Results posted
• Peginterferon Alpha-2b And Ribavirin to Treat Hepatitis C in HIV-Infected PatientsCompletedNCT00018031Phase 2Results posted
• Long Term Interferon for Patients Who Did Not Clear Hepatitis C Virus With Standard TreatmentCompletedNCT00006164Phase 3Results posted
• IFNL4 Genotype for Predicting Response to Ledipasvir/SofosbuvirWithdrawnNCT03639207
• People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral AgentsActive, not recruitingNCT03520660Phase 4
• Hepatitis B Reactivation During Treatment With Direct-Acting Antiviral Agents for Chronic Hepatitis C InfectionCompletedNCT03248622
• DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus InfectionActive, not recruitingNCT02772003Phase 1
• Navitoclax and Sorafenib Tosylate in Treating Patients With Relapsed or Refractory Solid TumorsCompletedNCT02143401Phase 1
• Long-Term Study of Liver Disease in People With Hepatitis B and/or Hepatitis C With or Without HIV InfectionCompletedNCT01350648
• Evaluating the Safety of ITX 5061 in Treatment-Naive Hepatitis C (HCV)-Infected AdultsCompletedNCT01165359Phase 1
• An Hepatitis B Vaccine Model for HIV Vaccine Trials in Drug UsersCompletedNCT00841477Phase 3
• Long-term Follow-up of HALT-C Sustained Virological RespondersCompletedNCT00825877
• Viral Kinetics and Liver Gene Expression in Response to Ribavirin and Peginterferon Therapy of Chronic Hepatitis CCompletedNCT00718172Phase 1
• Phase II Trial of Silymarin for Patients With Chronic Hepatitis C Who Have Failed Conventional Antiviral TreatmentCompletedNCT00680342Phase 2
• Hepatitis C Treatment and AtherosclerosisCompletedNCT00659256
• Psychoeducation for Hepatitis and Alcohol BehaviorsCompletedNCT00598416Not applicable
• Chronic Hepatitis Intervention Project for Drug UsersCompletedNCT00596843Phase 3
• Chiron Corp HCV E1/E2 VaccineCompletedNCT00500747Phase 1
• TG4040 in Patients With Chronic HCVWithdrawnNCT00449124Phase 1
• Determining Responses to Two Different Vaccines in HIV and HCV Infected IndividualsCompletedNCT00393276Phase 1
• Study to Reduce Intravenous Exposures (STRIVE)CompletedNCT00391482Phase 2/3
• Phase I Trial of Silymarin for Chronic Liver DiseasesCompletedNCT00389376Phase 1
• Transplant-Related Accelerated Progression of Hepatitis CCompletedNCT00368225
• Association Between Hepatitis C Virus Infection and Hematologic and Thyroid CancersCompletedNCT00342641
• The Second Multicenter Hemophilia Cohort StudyCompletedNCT00341705
• Interferon-Induced Gene Expression in Liver Cells and Peripheral Blood LymphocytesCompletedNCT00324389Phase 2
• Bridging Active Heroin Users to Hepatitis C Treatment Using Buprenorphine - 1CompletedNCT00249574Not applicable
• Preventing Depression in Methadone Maintenance Patients Receiving Hepatitis C Treatment - 1CompletedNCT00218556Not applicable
• Treatment of Acute Hepatitis C Virus Infection With Pegylated Interferon in Injection Drug UsersCompletedNCT00194480Phase 4
• Effects of Anti-HIV Therapy on Treatment for Hepatitis C in HCV/HIV Infected AdultsCompletedNCT00100581Not applicable
• Leukapheresis for Research on HCV-Coinfected PatientsCompletedNCT00076427
• Racial Difference in HCV/Host InteractionsCompletedNCT00071916
• Hepatitis C: Grading and Staging by MRCompletedNCT00059397
• Zidovudine Levels in HIV Infected Patients Being Treated for HCVCompletedNCT00059358Phase 1/2
• Treatment of Cholestatic Pruritus With SertralineCompletedNCT00058903Phase 2
• IdB 1016 Treatment for Hepatitis C DiseaseCompletedNCT00055445Phase 1/2
• Treatment of Hepatitis C in Hemophilic Patients With HIVCompletedNCT00055341Phase 2
• Treatment of Hepatitis in Patients Who Are Triple-Infected With HIV, Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV)WithdrawnNCT00051077Phase 2
• Hepatitis C Antiviral Resistance in African-AmericansCompletedNCT00038974Phase 3
• Prevalence of Hepatitis C Virus Infection in HIV-Infected ChildrenCompletedNCT00037076
• The Impact of HAART on Response to Hepatitis C Treatment in Patients Taking Peginterferon Alpha-2b and RibavirinCompletedNCT00031343Phase 2
• Evaluating Silymarin for Chronic Hepatitis CCompletedNCT00030030Phase 2
• Gamma Interferon Therapy for Chronic Hepatitis CCompletedNCT00028275Phase 2
• Effect of a Change in HIV Therapy on Liver Steatosis, Inflammation, and FibrosisWithdrawnNCT00023218Not applicable
• Effects of Ribavirin on Zidovudine or StavudineCompletedNCT00021632
• Interleukin-2 (IL-2), Pegylated Interferon (PEG-IFN Alfa-2b), and Ribavirin (RBV) Treatment in Patients With Hepatitis C and HIV CoinfectionCompletedNCT00015652Not applicable
• Herbal Treatment of Hepatitis C in Methadone Maintained PatientsCompletedNCT00010816Phase 2
• A Comparison of the Effectiveness, Safety, and Tolerability of Two Different Hepatitis C Treatments in Patients Infected With Both HIV and Hepatitis C Virus (HCV)CompletedNCT00008463Phase 2
• Comparing Single Photon Emission Computed Tomography (SPECT) and Liver Biopsy to Evaluate the Liver in Patients With HIV and Hepatitis C VirusCompletedNCT00006643
• Immune Response to Hepatitis C VirusCompletedNCT00006301
• Genetics of Hepatitis C Virus InfectionCompletedNCT00005657
• Generation of Anti-HCV Antibodies From Bone Marrow: Defining the Repertoire of Immune Response to HCV QuasispeciesCompletedNCT00004851
• Epidemiology, Infectivity and Natural History of Hepatitis C Virus InfectionCompletedNCT00004850
• Nucleic Acid Amplification Testing (NAT) of Blood Donors for HCV and HIVCompletedNCT00004846
• Phase III Randomized Study of High Vs Standard Dose of Interferon Alfa for Chronic Hepatitis CCompletedNCT00004804Phase 3
• History of Hepatitis C in Volunteer Blood DonorsCompletedNCT00001982
• Long-Term Therapy With Ribavirin for Chronic Hepatitis CCompletedNCT00001854Phase 4
• Combination Drug Therapy for Patients With Hepatitis CCompletedNCT00001729Phase 3
• Frequency of Parenteral and Non-Parenteral Exposures to Blood Among Healthcare Workers at the Clinical Center, NIH and at Seven Academic Hospitals in JapanCompletedNCT00001712
• A Study to Evaluate the Effects of Anti-HIV Drugs in HIV-Positive Patients Who Also Have Hepatitis C InfectionCompletedNCT00001117
• The Safety and Effectiveness of a Two-Drug Combination in the Treatment of Patients With Hepatitis C Plus Advanced HIV InfectionsCompletedNCT00001035Phase 1