Hypertension clinical trials
The registry lists 6,114 studies for Hypertension across more than 10 countries. 912 are recruiting or about to start. 3,891 of them are mainly about Hypertension (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 13 narrower conditions too, such as Hypertension, Pulmonary: 9,073 studies, 1,575 open.
ClinicalTrials.gov finds 12,610 studies for Hypertension. How that becomes 6,112 here
This page counts the studies the registry files under Hypertension, and those it files under no condition that list Hypertensionthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 12,610Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −2,927Filed under a narrower condition, counted on its own pageHypertension, Pulmonary 996 · Pre-Eclampsia 794 · Pulmonary Arterial Hypertension 499 · Essential Hypertension 296 · Hypertension, Pregnancy-Induced 89 · Cirrhosis, Familial, with Pulmonary Hypertension 37 · 7 more
- −1,322List Hypertension as a condition, but the registry did not file them under itMost often written as “Ocular Hypertension” (506), “Portal Hypertension” (239), and “Intracranial Hypertension” (76). The registry filed 16 of them under no condition at all, and the others under other conditions only, most often Ocular Hypertension (571) and Glaucoma, Open-Angle (385).
- −2,249Match it another way403 name it in the title, 136 in a keyword, and 1,710 by a synonym or other text the search reads.
- 6,112The count on this page174 of them list Hypertension in their own words; the registry filed them under no condition.
Get an email when these change. Save the Hypertension studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
National Heart, Lung, and Blood Institute (NHLBI) (160) · Novartis (143) · Boehringer Ingelheim (122) · AstraZeneca (69) · Novartis Pharmaceuticals (65) · Chong Kun Dang Pharmaceutical (59) · Brigham and Women's Hospital (53) · Johns Hopkins University (49)
What is being tested here
Drugs under test in Hypertension studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Amlodipine | 7 | 69 | 182 |
| Losartan | 5 | 18 | 64 |
| Eplerenone | 5 | 2 | 24 |
| Chlorthalidone | 4 | 8 | 24 |
| Aspirin | 4 | 2 | 11 |
| Nifedipine | 3 | 8 | 27 |
| Spironolactone | 3 | 2 | 19 |
| Enalapril | 3 | 5 | 16 |
| Labetalol | 3 | 2 | 12 |
| Dexmedetomidine | 3 | 5 | 9 |
Drug classes tested here Calcium channel blockers 13 open · Angiotensin receptor blockers (ARBs) 12 open · Mineralocorticoid receptor antagonists (MRAs) 11 open · Diuretics 10 open · Thiazide diuretics 6 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026A Randomized, Double-blind, Multi-center, Active-controlled, Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of Combination Therapy of THP-00101, THP-00102, and THP-00103 in Subjects With T2DM and Essential Hypertension · Phase 3 · THPharm Corp.
- Dec 2026A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension · Phase 3 · United Therapeutics
- Jan 2027PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis · Phase 3 · University of Alabama at Birmingham
- Sep 2027A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening) · Phase 3 · Eli Lilly and Company
- Sep 2027A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1 · Phase 3 · Eli Lilly and Company
- Sep 2027A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2 · Phase 3 · Eli Lilly and Company
- Oct 2027Cardiovascular Protection After Preeclampsia With Enalapril · Phase 3 · Women and Infants Hospital of Rhode Island
- Oct 2027A Study to Evaluate Efficacy and Safety of HCP1803-4 in Patients With Essential Hypertension · Phase 3 · Hanmi Pharmaceutical Company Limited
- Nov 2027Huayu Jiedu Formula (FTFY-919) Granules Versus Traditional Decoction for Acute Hypertensive Intracerebral Hemorrhage · Phase 3 · Guangzhou University of Traditional Chinese Medicine
- Nov 2026Dual-Language B-MORE for Hypertension · Florida State University
Who these studies take
Of the 564 Hypertension studies recruiting now, 266 (47%) set no upper age limit and 200 (35%) stop at 75 or younger. 40 (7%) take children under 18. 55 (10%) are for women only and 4 (1%) for men only; 138 (24%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 30 (5%) | 28 (5%) |
| 18 | 384 (68%) | 346 (61%) |
| 30 | 452 (80%) | 409 (73%) |
| 40 | 479 (85%) | 437 (77%) |
| 50 | 498 (88%) | 456 (81%) |
| 65 | 486 (86%) | 450 (80%) |
| 75 | 410 (73%) | 382 (68%) |
| 85 | 315 (56%) | 290 (51%) |
Across all 6,114 studies, recruiting or not: 36% stop at 75 or younger and 21% at 65; 10% take children; 6% are for women only and 5% for men only; 25% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypertension studies take
Of 175 phase 1 interventional studies under Hypertension, half reached primary completion within 4 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 4 mo1–17 · 175 studies | 2 mo1–8 · 131 studies | 36 mo12–… · 44 studies |
| Phase 1/2 | 41 mo6–60 · 20 studies | — | — |
| Phase 2 | 25 mo11–56 · 110 studies | 14 mo9–22 · 56 studies | 53 mo28–75 · 54 studies |
| Phase 2/3 | 23 mo10–41 · 15 studies | — | — |
| Phase 3 | 21 mo12–42 · 141 studies | 18 mo11–29 · 95 studies | 39 mo19–71 · 46 studies |
| Phase 4 | 31 mo16–52 · 161 studies | 22 mo16–31 · 35 studies | 36 mo15–54 · 126 studies |
| Interventional, no phase | 23 mo10–41 · 1,498 studies | 34 mo12–55 · 95 studies | 23 mo10–41 · 1,403 studies |
| Observational | 38 mo17–96 · 426 studies | 29 mo14–45 · 81 studies | 44 mo17–111 · 345 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting16
- Trial Phase: Syndemic Adapted Medly UgandaNov 6, 2026NCT07525271
- Investigating Vascular Properties of HEMI and SPG Signals in Individuals With or at Risk for Chronic Kidney DiseaseNov 6, 2026NCT07604922
- Anticipated Stigma, Illness Identity, and Quality of Life in Male HypogonadismNov 6, 2026NCT07752511
- Guiding Optimal Blood Pressure Management in Peritoneal Dialysis Pilot TrialNov 6, 2026NCT07910773
- Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in HumansNov 4, 2026NCT07602166
Show 11 moreShow fewer
- Genetics of Type 2 Diabetes in West AfricansNov 3, 2026NCT00837122
- Observational Study for the Characterisation of Patients Affected by Any Type of Diabetes and Endocrine DisordersNov 3, 2026NCT07206875
- Dry Weight Reduction Intervention Via Extra UltrafiltrationOct 30, 2026NCT07637110
- The Acute Effect of Exercise Type And Timing on Ambulatory Blood Pressure and Intra-Ocular Pressure in Individuals With Glaucoma (The ACHIEVE-project).Oct 29, 2026NCT07413614
- Osilodrostat in Patients With Hypertension Caused by Hypercortisolaemia Due to Cushing's SyndromeOct 28, 2026NCT07247162
- Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood PressureOct 28, 2026NCT07778966
- Determinants of Malignant Hypertension Onset and Related Target Organ Damages: the HAMA BiobankOct 22, 2026NCT06629363
- Reliability of Multiple-Repetition-Maximum Tests in Patients With Cardiovascular Disease or Risk FactorsOct 22, 2026NCT06796582
- A Real-world Study of the Effectiveness of Angiotensin Receptor-Neprilysin Inhibitor Therapy in Hypertensive Patients in the United Arab EmiratesOct 21, 2026NCT07465666
- Effectiveness and Cost-Effectiveness of a Digital Care Pathway and Asynchronous Communication for Patients With HypertensionOct 21, 2026NCT07812350
- Hypertension Treatment in Nigeria 2.0Oct 14, 2026NCT07351162
Results posted5
- Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe Chronic Kidney Disease (CKD)Nov 4, 2026NCT04968184
- Benidipine in Hypertensive and/or Chronic Coronary Syndrome PatientsNov 4, 2026NCT06808321
- Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With HypertensionNov 3, 2026NCT05925569
- Delivering a Digital Health Intervention to Improve Food Access and Dietary Quality Among Adults With HypertensionNov 3, 2026NCT06743191
- HealthMatters@24/7 eLearning for People Supporting Adults With Intellectual and Developmental DisabilitiesOct 14, 2026NCT03206164
Newly registered42
- A Study to Evaluate the Best Ways to Implement a Community Health Worker-supported Telehealth Program for Managing High Blood Pressure in KenyaNov 9, 2026NCT07927114
- Digital Reinforcement of Motivational Interviewing Micro-Skills Among Primary Care Healthcare ProfessionalsNov 6, 2026NCT07922837
- Community Health Worker Nutrition Self-Management Support for Cardio-Kidney-Metabolic HealthNov 5, 2026NCT07918508
- Comparison of Sequential vs. Simultaneous Adrenal Vein SamplingNov 5, 2026NCT07918794
- A Research Study to Investigate How Well the Medicine CagriSema Lowers High Blood Pressure in People Living With High Blood Pressure and ObesityNov 5, 2026NCT07919405
Show 37 moreShow fewer
- A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure ControlNov 4, 2026NCT07915752
- Use and Acceptability of an AI-Assisted Health Application for Individuals Living With a Chronic ConditionNov 4, 2026NCT07916753
- Study of AB-110 in Healthy and Hypertensive ParticipantsNov 4, 2026NCT07916961
- Multimodal AI-Driven Out-of-Hospital Management for Hypertension and Cardiometabolic RiskNov 4, 2026NCT07917676
- Real-World Validation of A Huawei Smartwatch for Hypertension Risk Screening in MalaysiaNov 3, 2026NCT07913581
- Real-World Validation of A Minimally Disruptive Ambulatory Blood Pressure Monitoring (ABPM) Huawei Smartwatch in MalaysiaNov 3, 2026NCT07913607
- Multicomponent Exercise Program in Women With HypertensionNov 3, 2026NCT07913971
- Kidney Stiffness Measured by Ultrasound in Patients With High Blood Pressure and Healthy VolunteersNov 3, 2026NCT07914075
- Implementation of a Person-Centered and Integrated Care Pathway for HypertensionNov 3, 2026NCT07914283
- Team-Based Shared Decision-Making Program in Hypertension Control (Healthy Heart - BP Program)Nov 2, 2026NCT07909161
- Guiding Optimal Blood Pressure Management in Peritoneal Dialysis Pilot TrialNov 2, 2026NCT07910773
- A Study to Evaluate the Effectiveness and Safety of S-amlodipine-based Monotherapy and Combination TherapyOct 30, 2026NCT07907822
- Effects of Smartphone Use and Television Viewing on Standardized BP Measurement: The SCREENS-BP StudyOct 29, 2026NCT07903779
- Care COMPASS StudyOct 29, 2026NCT07904793
- Under Pressure: Arugula Extract's Effect on Blood Pressure in Hypertensive IndividualsOct 29, 2026NCT07904832
- A Bioequivalence and Safety Study of AJU-C719 and C719R in Healthy Adult VolunteersOct 28, 2026NCT07901114
- Renal Denervation in Patients With Atrial Fibrillation and HypertensionOct 26, 2026NCT07893821
- IMB-Guided Health Education Intervention for Medication Adherence and Blood Pressure Control in Non-adherent Hypertensive PatientsOct 26, 2026NCT07894068
- THE EFFECT OF EDUCATION IN PATIENTS WITH HYPERTENSIONOct 22, 2026NCT07890090
- Stopping Blood Pressure Medications Without Tapering in Long-Term CareOct 22, 2026NCT07890129
- Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity RisksOct 21, 2026NCT07884903
- HUGO-SLEEVE: Evaluating the Feasibility of Robotic Sleeve Gastrectomy With a New PlatformOct 21, 2026NCT07884994
- Effect of Home and Remote Blood Pressure Monitoring Via Home BP Monitoring System (HMS) on Adults With Hypertension in TaiwanOct 21, 2026NCT07887542
- Validation of Cor-IS Impedance Spectroscopy Against Ultrasound Flow-Mediated DilationOct 20, 2026NCT07882550
- The First-in-Human Study of GW906 InjectionOct 20, 2026NCT07884461
- An Extension Trial of GW 906 in Participants With Essential HypertensionOct 19, 2026NCT07879755
- Cardiovascular Impacts of E-cigarettes Among Older AdultsOct 19, 2026NCT07880704
- Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 YearsOct 19, 2026NCT07880717
- Prevalence, Clinical Characteristics and Treatment of Bulgarian Patients With Resistant HypertensionOct 16, 2026NCT07877844
- Text Message Support to Help Adults With Newly Diagnosed High Blood Pressure Control Their Blood Pressure in Primary Care Clinics in Germany and PakistanOct 16, 2026NCT07878728
- Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia (NADI-MyHeartRisk)Oct 16, 2026NCT07879144
- The Effect of Ablation Duration of Renal Denervation on Antihypertensive EfficacyOct 15, 2026NCT07876479
- Sitogilun Malate Plus Amlodipine in Patients With Hypertension and Risk of Early Kidney DamageOct 15, 2026NCT07876544
- Evaluation of MTHFR Gene Polymorphism and Periodontal Clinical Parameters in Healthy, Hypertensive, and Periodontitis IndividualsOct 14, 2026NCT07873385
- Antihypertensive Self-titration in US Primary CareOct 13, 2026NCT07869966
- Cardiovascular Risk in Patients With Primary HyperparathyroidismOct 13, 2026NCT07870369
- Oliceridine Versus Sufentanil for Blood Pressure Control During Anesthesia Induction in Older Women With Hypertension Undergoing Gynecological Laparoscopic SurgeryOct 13, 2026NCT07871500
Studies
Recruiting first, then most recently updated. Showing 50 of 6,114. Browse all 6,114 → or search them.
- A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart DiseaseRecruitingNCT07214376Not applicable2 countries
- No Time to Pause: Physical Activity to Improve Health of Midlife Hispanic WomenNot yet recruitingNCT06376812Not applicable1 country
- A Phase II Clinical Trial to Evaluate the Efficacy and Safety of QLS1410 Tablets in Patients With Uncontrolled Hypertension Who Are Receiving One or More Background Drug TreatmentsNot yet recruitingNCT07927556Phase 2
- The REACH-OUT TrialRecruitingNCT07540143Not applicable1 country
- Treatment of Supine Hypertension in Autonomic Failure (CPAP)RecruitingNCT03312556Not applicable1 country
- Gut Microbiota in Metabolic SurgeryRecruitingNCT050009961 country
- A Study to Evaluate the Best Ways to Implement a Community Health Worker-supported Telehealth Program for Managing High Blood Pressure in KenyaNot yet recruitingNCT07927114Not applicable1 country
- Investigating Vascular Properties of HEMI and SPG Signals in Individuals With or at Risk for Chronic Kidney DiseaseRecruitingNCT07604922Not applicable1 country
- Trial Phase: Syndemic Adapted Medly UgandaRecruitingNCT07525271Not applicable1 country
- Guiding Optimal Blood Pressure Management in Peritoneal Dialysis Pilot TrialRecruitingNCT07910773Not applicable1 country
- Testing Implementation Strategies to Support Clinic Fidelity to an Outpatient Hypertension BundleEnrolling by invitationNCT06002165Not applicable1 country
- Use and Acceptability of an AI-Assisted Health Application for Individuals Living With a Chronic ConditionNot yet recruitingNCT07916753Not applicable1 country
- A MOST Framework Trial Evaluating the MOst effectiVe Exercise Types for Blood Pressure ControlNot yet recruitingNCT07915752Not applicable1 country
- A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood PressureRecruitingNCT06742723Phase 342 countries
- Anticipated Stigma, Illness Identity, and Quality of Life in Male HypogonadismRecruitingNCT077525111 country
- Community Health Worker Nutrition Self-Management Support for Cardio-Kidney-Metabolic HealthNot yet recruitingNCT07918508Not applicable1 country
- Trauma-informed Approach to Timely Detection and Management of Early Postpartum HypertensionRecruitingNCT05884190Not applicable1 country
- Truway Diagnostic Tools in Primary CareEnrolling by invitationNCT07209527Early Phase 11 country
- A Research Study to Investigate How Well the Medicine CagriSema Lowers High Blood Pressure in People Living With High Blood Pressure and ObesityNot yet recruitingNCT07919405Phase 319 countries
- Furosemide vs Placebo in Severe Preeclampsia PostpartumNot yet recruitingNCT07648251Phase 21 country
- Study of AB-110 in Healthy and Hypertensive ParticipantsNot yet recruitingNCT07916961Phase 11 country
- A Study Evaluating the Efficacy and Safety of SYH2072 Tablets In Hypertensive PatientsNot yet recruitingNCT07911735Phase 2
- Multimodal AI-Driven Out-of-Hospital Management for Hypertension and Cardiometabolic RiskNot yet recruitingNCT07917676Not applicable
- Telemonitoring of Blood Pressure in Local PharmaciesRecruitingNCT037814011 country
- A Study of Modified Release RTN-001 In Patients With Uncontrolled HypertensionRecruitingNCT07142356Phase 21 country
- Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney DiseaseRecruitingNCT072600711 country
- Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in HumansRecruitingNCT07602166Phase 21 country
- Real-World Validation of A Huawei Smartwatch for Hypertension Risk Screening in MalaysiaEnrolling by invitationNCT079135811 country
- Kidney Stiffness Measured by Ultrasound in Patients With High Blood Pressure and Healthy VolunteersRecruitingNCT079140751 country
- A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular EventRecruitingNCT07783802Phase 24 countries
- Real-World Validation of A Minimally Disruptive Ambulatory Blood Pressure Monitoring (ABPM) Huawei Smartwatch in MalaysiaEnrolling by invitationNCT079136071 country
- Genetics of Type 2 Diabetes in West AfricansRecruitingNCT008371222 countries
- Observational Study for the Characterisation of Patients Affected by Any Type of Diabetes and Endocrine DisordersRecruitingNCT072068751 country
- Household Salt Substitution for Hypertension Prevention and Control: The HOME-Salt TrialNot yet recruitingNCT07840742Not applicable1 country
- Common Carotid Artery-Renal Artery-Femoral Artery Survey for HypertensionNot yet recruitingNCT077606231 country
- PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility StudyNot yet recruitingNCT053773201 country
- Implementation of a Person-Centered and Integrated Care Pathway for HypertensionNot yet recruitingNCT07914283Not applicable
- Osilodrostat in Patients With Hypertension Caused by Hypercortisolaemia Due to Cushing's SyndromeRecruitingNCT07247162Phase 41 country
- Autonomic and Renal Contributions to Hypertension With ADTRecruitingNCT07848828Phase 41 country
- Team-Based Shared Decision-Making Program in Hypertension Control (Healthy Heart - BP Program)Not yet recruitingNCT07909161Not applicable
- Dry Weight Reduction Intervention Via Extra UltrafiltrationRecruitingNCT07637110Not applicable1 country
- Clevidipine for the Antihypertensive Treatment of Acute Intracerebral HemorrhageRecruitingNCT064029681 country
- A Study to Evaluate the Effectiveness and Safety of S-amlodipine-based Monotherapy and Combination TherapyNot yet recruitingNCT07907822
- The Acute Effect of Exercise Type And Timing on Ambulatory Blood Pressure and Intra-Ocular Pressure in Individuals With Glaucoma (The ACHIEVE-project).RecruitingNCT07413614Not applicable1 country
- Diabetes and Heart Disease Risk in BlacksRecruitingNCT000018531 country
- Care COMPASS StudyNot yet recruitingNCT07904793Not applicable1 country
- Effects of Smartphone Use and Television Viewing on Standardized BP Measurement: The SCREENS-BP StudyNot yet recruitingNCT07903779Not applicable2 countries
- A Bioequivalence and Safety Study of AJU-C719 and C719R in Healthy Adult VolunteersNot yet recruitingNCT07901114Phase 11 country
- Real-World Validation for Less-Disturbing Ambulatory Blood Pressure Monitoring (ABPM) in Malaysia Using Huawei WearablesNot yet recruitingNCT077909781 country
- Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood PressureRecruitingNCT07778966Not applicable1 country