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Cirrhosis, Familial, with Pulmonary Hypertension clinical trials

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The registry lists 37 studies for Cirrhosis, Familial, with Pulmonary Hypertension across 8 countries. 26 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-11-10.

Status

Recruiting
16
Not yet recruiting
10
Completed
5
Active, not recruiting
3
Terminated
2
Status unknown
1

Phase

Phase 2
19
Phase 3
2
Phase 1
2

Where

China
25
United States
5
France
2
Netherlands
2
Korea, Republic of
1
Italy
1

Who develops what

Add Cirrhosis, Familial, with Pulmonary Hypertension to watchlistPro · free during the betaEvery Monday by email · turn it off any time

Every program with a company-led study here in the last two years, whatever its size: 2 programs from 2 companies, 0 with this as their studies’ main aim; 1 with a live phase 3 study; 1 primary completion in the next 12 months.

Comparator & background therapies

What other companies’ phase 2+ studies give as the comparator or the background here (its leading trial sponsor and partners left out): a sign of what new drugs are measured against, not by itself the standard of care, its prescriptions or its market.

DrugLeading trial sponsor · rightsCompanies, last 5 years
OxaliplatinRecent, limitedPhase 4 trial recorded
Evidence
  • NCT07328919 · TransThera Sciences (Nanjing), Inc. · Phase 3 · live · comparator · “Oxaliplatin, fluorouracil, calcium folinate, irinotecan, capecitabine” · registered Dec 2025
Sanofi35% of its industry studies11 study
FluorouracilRecent, limited
Evidence
  • NCT07328919 · TransThera Sciences (Nanjing), Inc. · Phase 3 · live · comparator · “Oxaliplatin, fluorouracil, calcium folinate, irinotecan, capecitabine” · registered Dec 2025
Sanofi20% of its industry studiesUS: off-patent, 19 generics marketed11 study
LeucovorinRecent, limited
Evidence
  • NCT07328919 · TransThera Sciences (Nanjing), Inc. · Phase 3 · live · comparator · “Oxaliplatin, fluorouracil, calcium folinate, irinotecan, capecitabine” · registered Dec 2025
Sanofi15% of its industry studiesUS: off-patent, 24 generics marketed11 study

2 more in limited or earlier use — sign in to see them, free.

Programs

“Meets, by arms” reads each study’s arms: vs its arm against the therapy’s; + X vs a combination against it; added to it plus the therapy against the therapy; studied with given together only. The next primary completion is the next phase-3 study’s when there is one.

The 2 programs — sign in to see the whole list, free: filter by phase and aim, sort by late development, direct comparisons or the next primary completion.

Primary completion in the next 12 months (1)

Live phase 2 and 3 studies of these programs. Primary completion is when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced.

  • Mar 2027 est.FGFR2/3 Inhibitor CGT4859 · Cogent Biosciences, Inc. · Phase 2 registry mapping onlyNCT06777316 A Study of an FGFR2/3 Inhibitor (CGT4859) in Patients With Cholangiocarcinoma and Other Advanced Solid Tumors — primary endpoint: Phase 1: Determine the maximum tolerated dose (MTD) and RP2D of CGT4859 - AEs · 110 enrolled

Read from ClinicalTrials.gov, industry-led studies. Main aim: this is the study’s judged main condition; named, not the main aim: the sponsor names it, the study is about something else; registry mapping only: only the registry’s mapping put it here. Leading trial sponsor is the company leading the most industry studies of a drug, a measure of trial activity, not of rights. US and EU rights, and Approved: from the regulators’ records (FDA’s Drugs@FDA via openFDA; EMA’s medicines data) — the holder of a marketed or authorized original, generics and other companies’ versions; not rights elsewhere, nor approval for this condition. Phase 4 trial recorded, where neither lists it: a phase 4 study exists somewhere. Not read yet: labels by indication, exclusivity, licenses, line of therapy, academic comparators, sales.

What is being tested here

Drugs under test in Cirrhosis, Familial, with Pulmonary Hypertension studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

Drug classes tested here Tyrosine kinase inhibitors (TKIs) 8 open · Immune checkpoint inhibitors 6 open · Antimetabolites 3 open

Coming up

8studies finish main data collection within a year

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

All 8

Who these studies take

Of the 16 Cirrhosis, Familial, with Pulmonary Hypertension studies recruiting now, 7 (44%) set no upper age limit and 5 (31%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (6%) take healthy volunteers.

Recruiting studies that take each age, of 16
AgeWomenMen
100 (0%)0 (0%)
1816 (100%)16 (100%)
3016 (100%)16 (100%)
4016 (100%)16 (100%)
5016 (100%)16 (100%)
6516 (100%)16 (100%)
7515 (94%)15 (94%)
859 (56%)9 (56%)

Across all 37 studies, recruiting or not: 22% stop at 75 or younger and 0% at 65; 5% take children; 0% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

Studies

Recruiting first, then most recently updated. Showing 37 of 37. search them.