Brigham and Women's Hospital: Hypertension trials

The registry lists 52 Hypertension studies with Brigham and Women's Hospital as lead sponsor. 6 are open to participants now and 21 have results posted.

Early Phase 1 1Phase 1 2Phase 2 5Phase 4 9No phase 36(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Antihypertensive Self-titration in US Primary CareNot yet recruitingNCT07869966Not applicable
• Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).Not yet recruitingNCT07832942Not applicable
• Fixed-Dose Combinations Pragmatic Randomized Implementation Trial for Blood Pressure ControlEnrolling by invitationNCT07228065Not applicable
• Reducing Heart Failure Risk in Late-Life With Physical ActivityNot yet recruitingNCT06247774Not applicable
• Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in HypertensionRecruitingNCT05593055Phase 4
• Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical StudyRecruitingNCT05030545Phase 4
• Social Norms, Messengers, and Processing Fluency to Increase Hypertension Medication AdherenceCompletedNCT06066541Not applicableResults posted
• Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/SotalolCompletedNCT05794997Results posted
• Implementation of a Combination Intervention for Sustainable Blood Pressure ControlCompletedNCT05492955Not applicableResults posted
• Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs TriamtereneCompletedNCT05125237Results posted
• Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Dihydropyridine Calcium Channel Blockers Versus HydrochlorothiazideCompletedNCT05125224Results posted
• Leveraging Electronic Health Record (EHR) Tools to Reduce Health Disparities for Patients With Uncontrolled HypertensionCompletedNCT05030467Not applicableResults posted
• Personalizing Intervention to Reduce Clinical Inertia in the Treatment of HypertensionCompletedNCT04603560Not applicableResults posted
• Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in ObesityCompletedNCT04519164Phase 4Results posted
• Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum PeriodCompletedNCT04236258Phase 4Results posted
• Mineralocorticoid Receptor (MR) Antagonist (Eplerenone) vs Amlodipine and STRIATINCompletedNCT03683069Phase 4Results posted
• Electronic Tools to Increase Recognition and Improve Primary Care Management for Hypertension in Chronic Kidney DiseaseCompletedNCT03679247Not applicableResults posted
• Evaluating the Navajo Community Outreach and Patient Empowerment (COPE) ProgramCompletedNCT03326206Results posted
• Impact of Community Health Workers on Adherence to Therapy for Non-Communicable Chronic Disease in Chiapas, MexicoCompletedNCT02549495Results posted
• Tele-Pharmacy Intervention to Improve Treatment AdherenceCompletedNCT02512276Not applicableResults posted
• The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension StudyTerminatedNCT02253394Phase 4Results posted
• Heart Health 4 Moms Trial to Reduce CVD Risk After PreeclampsiaCompletedNCT02147626Not applicableResults posted
• The Impact of Nebivolol Versus Metoprolol on Quality of LifeTerminatedNCT01441570Not applicableResults posted
• An Open-Label Uncontrolled Study of the Safety and Efficacy of Ambrisentan in Participants With Exercise-Induced Pulmonary Arterial Hypertension (PAH)CompletedNCT01338636Phase 4Results posted
• Vitamin D Supplementation Reduces Renin-Angiotensin System Activity in ObesityCompletedNCT01068418Not applicableResults posted
• The Role of Endothelin in Pulmonary HypertensionCompletedNCT00759408Phase 2Results posted
• Melatonin Supplements for Improving Sleep in Individuals With HypertensionCompletedNCT00238108Phase 2Results posted
• Better Understanding Patient Perspectives of an Educational Tool for Postpartum Hypertensive PatientsActive, not recruitingNCT06996496Not applicable
• Electronic Alert to Improve Testing For Primary Aldosteronism in Patients With HypertensionActive, not recruitingNCT05925569Not applicable
• MR Antagonist and LSD1CompletedNCT04840342Phase 4
• Replication of the TRANSCEND Antihypertensive Trial in Healthcare Claims DataCompletedNCT04354376
• Replication of the ONTARGET Antihypertensive Trial in Healthcare Claims DataCompletedNCT04354350
• Comparison of Vasodilator Response of Inhaled Epoprostenol and Inhaled Nitric OxideCompletedNCT04231084Phase 4
• Angiogenic Imaging in Pulmonary Arterial HypertensionCompletedNCT03166306Phase 1/2
• Potatoes, Hypertension RIsk and Endothelial Function StudyCompletedNCT03116919Not applicable
• Medication Adherence Improvement Support App For Engagement - Blood PressureCompletedNCT02727543Not applicable
• e-Pharmacovigilance II - Surveillance for Safety and Effectiveness - Calling for Earlier Detection of Adverse ReactionsStatus unknownNCT02087293Not applicable
• Evaluation of a Decision Support ToolStatus unknownNCT02060981Not applicable
• Evaluation of Lysine-Specific Demethylase 1WithdrawnNCT01702688Not applicable
• Vitamin D and Omega-3 Hypertension Trial (VITAL Hypertension)Active, not recruitingNCT01653678Not applicable
• Preeclampsia: A Marker for Future Cardiovascular Risk in WomenSuspendedNCT01519297Not applicable
• L-Arginine, Vascular Response and MechanismsCompletedNCT01482247Phase 2
• Genetic Mechanisms in Human HypertensionTerminatedNCT01456208
• Caveolin-1 and Vascular DysfunctionActive, not recruitingNCT01426529Phase 1
• Impact of Computerized Decision Support on Racial/Ethnic Disparities in Hypertension OutcomesStatus unknownNCT01083940Early Phase 1
• Genetic Mechanisms in Human Hypertension Renin-angiotensin-aldosterone System (RAAS) Inhibition StudyWithdrawnNCT01009944Not applicable
• Clinical Decision Support ConsortiumStatus unknownNCT00853619Not applicable
• Flavanol-Rich Cocoa and Cerebral Blood FlowCompletedNCT00825695Not applicable
• The Effect of Providing Free Samples of Generic Cardiovascular Medications to PhysiciansStatus unknownNCT00761904Not applicable
• Cocoa, Polyphenols, and the Kidney in Healthy Subjects and in Subjects With Hypertension and Diabetes MellitusCompletedNCT00639665
• Biochemical and Genetic Markers of Hypertension in WomenCompletedNCT00090467
• Polyunsaturates and KCL to Control Mild HypertensionCompletedNCT00000511Phase 2