Hypertension Resistant to Conventional Therapy clinical trials
The registry lists 47 studies for Hypertension Resistant to Conventional Therapy across more than 10 countries. 3 are recruiting or about to start. 43 of them are mainly about Hypertension Resistant to Conventional Therapy (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
BackBeat Medical Inc (4) · Assistance Publique - Hôpitaux de Paris (2) · University of Cambridge (2) · University Hospital, Grenoble (2) · Macmillan Research Group UK (1) · Charite University, Berlin, Germany (1) · Tomsk National Research Medical Center of the Russian Academy of Sciences (1) · Cardiovascular Center Frankfurt (1)
What is being tested here
Drugs under test in Hypertension Resistant to Conventional Therapy studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Minocycline | 1 | 0 | 1 |
| Spironolactone | 0 | 1 | 4 |
| Furosemide | 0 | 0 | 1 |
| Amiloride | 0 | 0 | 1 |
| Enalapril | 0 | 0 | 1 |
| Lisinopril | 0 | 0 | 1 |
| Bisoprolol | 0 | 0 | 1 |
| Doxazosin | 0 | 0 | 1 |
| Losartan | 0 | 0 | 1 |
| Hydrochlorothiazide | 0 | 0 | 1 |
Who these studies take
Of the 2 Hypertension Resistant to Conventional Therapy studies recruiting now, 0 (0%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (50%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 2 (100%) | 2 (100%) |
| 30 | 2 (100%) | 2 (100%) |
| 40 | 2 (100%) | 2 (100%) |
| 50 | 2 (100%) | 2 (100%) |
| 65 | 2 (100%) | 2 (100%) |
| 75 | 2 (100%) | 2 (100%) |
| 85 | 1 (50%) | 1 (50%) |
Across all 47 studies, recruiting or not: 36% stop at 75 or younger and 9% at 65; 0% take children; 0% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 15, 2026.
Stopped1
- Baroloop Multicenter Trial (Baroloop MCT)TerminatedOct 20, 2026NCT06518915
Studies
Recruiting first, then most recently updated. Showing 47 of 47. search them.
- Antihypertensive Mechanisms of Minocycline in Resistant HypertensionRecruitingNCT06246396Phase 41 country
- Expand Management of Blood Pressure With Renal Denervation in Patients Undergoing Staged PCI for Advanced Coronary Artery diseasENot yet recruitingNCT07602790Not applicable
- Physical Activity Program for Reducing Blood Pressure in Sleep Apnea Patients with Resistant HypertensionRecruitingNCT02057783Not applicable3 countries
- A Preventive, Multidisciplinary Primary Care Intervention Organized Around a Therapeutic Garden: Acceptability to Patients Suffering From Cardio-neurovascular Pathology and to Those Involved in the Action.Active, not recruitingNCT06646601Not applicable1 country
- Baroloop Multicenter Trial (Baroloop MCT)TerminatedNCT06518915Not applicable2 countries
- Moderato System: A Double-Blind Randomized Trial Ver 1.1TerminatedNCT02837445Not applicable7 countries
- Moderato System in Patients With HypertensionTerminatedNCT03757377Not applicable3 countries
- High Prevalence of Secondary Arterial Hypertension (HIPRESH) with Prospective Systematic Screening in a Cohort of Consecutive Hypertensive Patients Referring to Regional Specialized CenterCompletedNCT06664255
- RADIANCE Continued Access ProtocolActive, not recruitingNCT05017935Not applicable1 country
- UK Registry for Baroreflex Activation TherapyTerminatedNCT03730519Not applicable1 country
- MANP in African Americans With HypertensionWithdrawnNCT04542681Phase 11 country
- Use of Automated Office Blood Pressure MonitoringCompletedNCT05395403Not applicable1 country
- Distal Renal DenervationCompletedNCT02667912Not applicable1 country
- Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial HypertensionCompletedNCT02832973Phase 41 country
- Rapid Renal Sympathetic Denervation for Resistant HypertensionCompletedNCT01520506Not applicable6 countries
- How to Test Success of a Renal DenervationTerminatedNCT025598821 country
- Renal Denervation in HypertensionCompletedNCT01570777Phase 41 country
- Chemical Renal Ethanol Sympatholysis Under CT Guidance Use for the Control of Therapy-Resistant HypertensionTerminatedNCT02653222Phase 21 country
- Safety and Performance Study of the Moderato SystemCompletedNCT02282033Not applicable7 countries
- Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis (ANDORRA)TerminatedNCT02539810Phase 41 country
- Peripheral Chemoreflex/Arterial Baroreflex Interaction in Patients With Electrical Carotid Sinus StimulationCompletedNCT02587533Not applicable1 country
- The Use of Educational Technology in Improving Adherence TherapyCompletedNCT03324386Not applicable
- Full Length Versus Proximal Renal Arteries AblationCompletedNCT01848275Not applicable1 country
- The Use of Ambulatory Blood Pressure Monitors to Assess Angiotensin Converting Enzyme InhibitorsStatus unknownNCT02623036Phase 11 country
- Health Coaching Based Treatment Versus Usual Treatment of Systemic Arterial Hypertension and ComorbiditiesStatus unknownNCT03046680Not applicable1 country
- Causal Inference Research of Resistant Hypertension Treatment With Chinese Approach in a Cohort StudyCompletedNCT01904695Early Phase 11 country
- Reintervention-study After Previous Renal Denervation in Non-responding Patients With Severe HypertensionCompletedNCT018341181 country
- Renal Sympathetic Denervation and Potential Effects on Glucose Metabolism and Cardiovascular Risk-FactorsCompletedNCT01630928Not applicable1 country
- A Study to Evaluate Safety and Efficacy of the Redy™ Renal Denervation System in the Treatment of Patients With Uncontrolled HypertensionStatus unknownNCT02690909Not applicable8 countries
- The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the PrognosisStatus unknownNCT017037801 country
- CPAP Effect on Blood Pressure and Arterial Stiffness in Obstructive Sleep Apnea Patients With Resistant HypertensionStatus unknownNCT023858641 country
- Effect of Renal Sympathetic Denervation on Resistant Hypertension and Cardiovascular Hemodynamic in Comparison to Intensive Medical Therapy Utilizing Impedance CardiographyStatus unknownNCT01673516Phase 21 country
- Optimum Treatment for Drug-Resistant HypertensionStatus unknownNCT02369081Phase 41 country
- Efficacy of Spironolactone in Cameroonian Diabetic Patients With Resistant HypertensionCompletedNCT02426099Phase 41 country
- Impact of Pacing Site and AV Delay on Blood Pressure in Hypertensive PatientsCompletedNCT02382484Not applicable1 country
- Medication Adherence and "True" Resistance in Patients With Resistant HypertensionStatus unknownNCT021283861 country
- Effect Baroreflex Activation Therapy on the Carotid BodyStatus unknownNCT022109231 country
- The Effect of Spironolactone on Blood Pressure in Type-2 Diabetics With Resistant HypertensionCompletedNCT01062763Phase 3
- Addition of Homeopathy in Patients With Resistant Arterial HypertensionCompletedNCT02124473Phase 21 country
- Continued Safety and Performance of the TIVUS SystemStatus unknownNCT01835535Phase 2/31 country
- Resistant Hypertension and Physical Activity Performed in a Heated PoolStatus unknownNCT01863082Not applicable1 country
- Safety and Efficacy Study of Extracorporeal Shockwave Therapy in the Treatment of Patients With Resistant HypertensionStatus unknownNCT02042066Phase 11 country
- Combined Treatment of Resistant Hypertension and Atrial FibrillationCompletedNCT01117025Phase 22 countries
- Monotherapy Versus Dual Therapy for Initial Treatment for HypertensionStatus unknownNCT00994617Phase 41 country
- Renin-angiotensin-aldosterone System Polymorphisms in Resistant Hypertension and Adverse Cardiovascular EventsCompletedNCT011730291 country
- Autonomic Dysfunction in Resistant HypertensionCompletedNCT018334291 country
- Prevalence of Primary Aldosteronism in Patients With Resistant Hypertension in ChinaCompletedNCT014590421 country