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Pulmonary Arterial Hypertension clinical trials

The registry lists 699 studies for Pulmonary Arterial Hypertension across more than 10 countries. 140 are recruiting or about to start. 628 of them are mainly about Pulmonary Arterial Hypertension (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.

ClinicalTrials.gov finds 2,098 studies for Pulmonary Arterial Hypertension. How that becomes 699 here

This page counts the studies the registry files under Pulmonary Arterial Hypertension, and those it files under no condition that list Pulmonary Arterial Hypertensionthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 2,098Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −18List Pulmonary Arterial Hypertension as a condition, but the registry did not file them under itMost often written as “Idiopathic Pulmonary Arterial Hypertension” (13), “Secondary Pulmonary Arterial Hypertension” (2), and “Heritable Pulmonary Arterial Hypertension” (2). The registry filed them under other conditions only, most often Familial Primary Pulmonary Hypertension (14) and Hypertension, Pulmonary (2).
  3. −1,381Match it another way125 name it in the title, 1 in a keyword, and 1,255 by a synonym or other text the search reads.
  4. 699The count on this page6 of them list Pulmonary Arterial Hypertension in their own words; the registry filed them under no condition.

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Status

Completed
341
Recruiting
90
Terminated
84
Status unknown
61
Not yet recruiting
45
Withdrawn
37

Phase

Phase 2
140
Phase 3
113
Phase 1
86
Phase 4
63
Early Phase 1
5

Where

United States
311
Germany
119
France
103
United Kingdom
98
Canada
85
Spain
77

Who runs them

Actelion (59) · United Therapeutics (44) · Bayer (19) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (13) · Novartis Pharmaceuticals (12) · Merck Sharp & Dohme LLC (12) · Bial - Portela C S.A. (12) · Assistance Publique - Hôpitaux de Paris (10)

What is being tested here

Drugs under test in Pulmonary Arterial Hypertension studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Sotatercept6517
Ambrisentan4820
Treprostinil31444
Tadalafil229
Macitentan11318
Sildenafil1818
Selexipag1612
Iloprost1512
Ralinepag135
Treprostinil hexadecyl ester124

Drug classes tested here Endothelin receptor antagonists 5 open · PDE5 inhibitors 3 open · Tyrosine kinase inhibitors (TKIs) 1 open · Diuretics 1 open · Bronchodilators 1 open

Coming up

20phase 3 studies under way
46studies finish main data collection within a year4 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 90 Pulmonary Arterial Hypertension studies recruiting now, 51 (57%) set no upper age limit and 24 (27%) stop at 75 or younger. 18 (20%) take children under 18. 1 (1%) are for women only and 0 (0%) for men only; 11 (12%) take healthy volunteers.

Recruiting studies that take each age, of 90
AgeWomenMen
1016 (18%)16 (18%)
1886 (96%)85 (94%)
3083 (92%)82 (91%)
4083 (92%)82 (91%)
5082 (91%)82 (91%)
6581 (90%)81 (90%)
7577 (86%)77 (86%)
8558 (64%)58 (64%)

Across all 699 studies, recruiting or not: 33% stop at 75 or younger and 15% at 65; 19% take children; 1% are for women only and 1% for men only; 14% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Pulmonary Arterial Hypertension studies take

Of 51 phase 2 interventional studies under Pulmonary Arterial Hypertension, half reached primary completion within 44 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 19 mo2–22 · 45 studies5 mo2–17 · 34 studies—
Phase 244 mo26–65 · 51 studies31 mo19–48 · 28 studies—
Phase 350 mo31–83 · 49 studies50 mo31–83 · 43 studies—
Interventional, no phase42 mo18–71 · 65 studies—44 mo18–63 · 60 studies
Observational58 mo30–93 · 85 studies—60 mo31–… · 64 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 15, 2026.

Started recruiting4

Newly registered2

Studies

Recruiting first, then most recently updated. Showing 50 of 699. Browse all 699 → or search them.