Drug
Eplerenone clinical trials
Also written Inspra.
- studies test it
- 95
- open now
- 17
- in phase 3
- 18
- first study started
- 2001
Keep track of what changes. Save the Eplerenone studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
93 studies that test it; most in 2013 (13); 2 more planned to start later
| Year | Studies |
|---|---|
| 2001 | 1 |
| 2003 | 4 |
| 2004 | 4 |
| 2005 | 1 |
| 2006 | 6 |
| 2007 | 7 |
| 2008 | 2 |
| 2009 | 2 |
| 2010 | 5 |
| 2011 | 3 |
| 2012 | 3 |
| 2013 | 13 |
| 2014 | 6 |
| 2015 | 4 |
| 2016 | 5 |
| 2017 | 4 |
| 2018 | 1 |
| 2019 | 2 |
| 2020 | 2 |
| 2021 | 1 |
| 2022 | 3 |
| 2023 | 6 |
| 2024 | 1 |
| 2025 | 2 |
| 2026 | 5 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 3
- Phase 1
- 8
- Phase 2
- 19
- Phase 3
- 18
- Phase 4
- 37
- No phase
- 15
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 14 · Other 81
Brigham and Women's Hospital (10) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (6) · Central Hospital, Nancy, France (3) · Massachusetts General Hospital (3) · Radboud University Medical Center (3) · Anna Stanhewicz, PhD (2) · Hippocration General Hospital (2) · Vanderbilt University Medical Center (2)
Often tested with
Tested in the same studies.
Spironolactone (5) · Amlodipine (4) · Aliskiren (3) · Valsartan (2) · Captopril (2) · Metoprolol (2) · Ramipril (2) · Chlorthalidone (2)
Studies
Open first, then newest update. How each study uses Eplerenone is read from its arms, and is right about nine times in ten.
Testing it · 95
- Reducing Arterial Inflammation Using Eplerenone and Statins in HIVNot yet recruitingPhase 2/3Massachusetts General HospitalNCT07892664Written as Eplerenone
- Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of PregnancyRecruitingPhase 2Massachusetts General HospitalNCT07238400Written as Eplerenone 100 mg daily
- Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical StudyRecruitingPhase 4Brigham and Women's HospitalNCT05030545Written as Eplerenone
- Cardiac Improvement by Eplerenone Among Patients Under Cyclosporine or Tacrolimus for Kidney Transplantation.Not yet recruitingPhase 3Central Hospital, Nancy, FranceNCT07828223Written as Eplerenone
- Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic StenosisNot yet recruitingPhase 2University College, LondonNCT07539259Written as Epleronone
- Eplerenone and IOP in Healthy AdultsNot yet recruitingPhase 1University of FloridaNCT07795762Written as Eplerenone
- Early Aldo Blockade in Subclinical PANot yet recruitingPhase 2/3Xinjiang Medical UniversityNCT07727252Written as Eplerenone
- Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in HypertensionRecruitingPhase 4Brigham and Women's HospitalNCT05593055Written as Eplerenone
- Stratified Medicine of Eplerenone in Acute Myocardial Infarction or Injury and no Obstructive Coronary Arteries.RecruitingPhase 2NHS National Waiting Times Centre BoardNCT05198791Written as Stratified medicine - Microvascular dysfunction and eplerenone therapy, tablets
- Swedish Cardiac And Renal Failure Study-1RecruitingPhase 2Karolinska InstitutetNCT07029503Written as Eplerenone
- Vascular Effects of High-Salt After PreeclampsiaRecruitingEarly Phase 1Anna Stanhewicz, PhDNCT06749418Written as Eplerenone
- Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical TreatmentRecruitingNot applicableGöteborg UniversityNCT05797558Written as Medical treatment (eplerenone)
- The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients.RecruitingPhase 3Central Hospital, Nancy, FranceNCT04450953Written as Eplerenone 50mg/day (cross over design)
- Optimal Medical Treatment of Difficult-to-treat HypertensionRecruitingPhase 4National Institute of Cardiology, Warsaw, PolandNCT06275763Written as Phase C: Eplerenone
- The Predictive Role of Urinary Proteomics in Blood Pressure Response of Obese Hypertensive Treated With Irbesartan or Eplerenone.RecruitingNot applicableHippocration General HospitalNCT06208072Written as Eplerenone 25 mg
- Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patient With Structural Heart DiseaseNot yet recruitingPhase 4Assiut UniversityNCT06168994Written as Eplerenone
- A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart FailureEnrolling by invitationPhase 4Bispebjerg HospitalNCT03984591Written as Eplerenone
- MR Antagonist and LSD1CompletedPhase 4Brigham and Women's HospitalNCT04840342Written as Eplerenone
- Aldosterone, the Mineralocorticoid Receptor, and Cardiovascular Disease in ObesityCompletedPhase 4Brigham and Women's HospitalNCT04519164Written as Eplerenone
- MR and Inflammation After PreeclampsiaActive, not recruitingEarly Phase 1Anna Stanhewicz, PhDNCT07345845Written as Eplerenone
See all 95 studies that test Eplerenone →
Given in every arm · 2 — Eplerenone is usual care beside what is tested
- Study to Investigate the Natriuretic Effects, Safety, Tolerability and Pharmacokinetics of BAY94-8862CompletedPhase 1BayerNCT01473108Written as Eplerenone (Inspra®)
- A Study to Assess the Pharmacodynamic Effect of Single Doses of AZD9977 in Healthy Male SubjectsCompletedPhase 1AstraZenecaNCT02532998Written as Eplerenone, tablets
As the comparator · 11 — what is tested is compared with Eplerenone
- Evaluation of Vamorolone Mineralocorticoid Receptor Antagonism in Healthy SubjectsCompletedPhase 1Santhera PharmaceuticalsNCT06649409Written as Eplerenone
- Bioequivalence Study of Test and Reference 50 mg Eplerenone Film-coated Tablets in Healthy VolunteersCompletedPhase 1Darnitsa Pharmaceutical CompanyNCT05663372Written as INSPRA® 50 mg eplerenone film-coated tablets
- Phase IIb Safety and Efficacy Study of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Moderate Chronic Kidney Disease AloneCompletedPhase 2BayerNCT01955694Written as Eplerenone
- A Study to Evaluate Efficacy and Safety of LCI699 in Participants With Essential HypertensionCompletedPhase 2Novartis PharmaceuticalsNCT00758524Written as Eplerenone
- Phase IIb Safety and Efficacy Study of Different Oral Doses of BAY94-8862 in Subjects With Worsening Chronic Heart Failure and Left Ventricular Systolic Dysfunction and Either Type 2 Diabetes Mellitus With or Without Chronic Kidney Disease or Chronic Kidney Disease AloneCompletedPhase 2BayerNCT01807221Written as Inspra (eplerenone)
- A Study to Evaluate the Efficacy and Safety of LCI699 Compared to Placebo in Participants With Resistant HypertensionCompletedPhase 2NovartisNCT00817635Written as Eplerenone
- LFF269 Compared to Placebo After Treatment in Subjects With Essential HypertensionTerminatedPhase 2Novartis PharmaceuticalsNCT01373086Written as Eplerenone
- A Study to Evaluate Efficacy and Safety of CS-3150 in Japanese Hypertensive SubjectsCompletedPhase 2Daiichi SankyoNCT02345044Written as eplerenone
- A Study of LY2623091 in Male and Females With Chronic Kidney DiseaseCompletedPhase 2Eli Lilly and CompanyNCT01427972Written as Eplerenone
- Multiple Dose Study of the Safety, Tolerability, Pharmacokinetics and Effect on Renal Potassium ClearanceCompletedPhase 1Eli Lilly and CompanyNCT01237899Written as Eplerenone
- Study of CS-3150 in Patients With Essential HypertensionCompletedPhase 3Daiichi Sankyo Co., Ltd.NCT02890173Written as Eplerenone
Codes
What other systems call Eplerenone · ClinicalTrials.gg INT006742
- MeSH (NLM) D000077545EplerenoneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 6995V82D0BEPLERENONEConfirmed FDA, NLM, Wikidata
- RxNorm 298869Confirmed FDA, Wikidata
- Wikidata Q423804eplerenoneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C47513EplerenoneConfirmed FDA, Wikidata
- DrugBank DB00700One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000077545 | Eplerenone | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 6995V82D0B | EPLERENONE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 298869 | — | Confirmed FDA, Wikidata |
| Wikidata | Q423804 | eplerenone | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C47513 | Eplerenone | Confirmed FDA, Wikidata |
| DrugBank | DB00700 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.