Pre-Eclampsia clinical trials
The registry lists 916 studies for Pre-Eclampsia across more than 10 countries. 243 are recruiting or about to start. 745 of them are mainly about Pre-Eclampsia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
ClinicalTrials.gov finds 982 studies for Pre-Eclampsia. How that becomes 916 here
This page counts the studies the registry files under Pre-Eclampsia, and those it files under no condition that list Pre-Eclampsiathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 982Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −23List Pre-Eclampsia as a condition, but the registry did not file them under itMost often written as “Postpartum Preeclampsia” (11), “Preeclampsia Severe” (4), and “Preeclampsia With Severe Features” (2). The registry filed them under other conditions only, most often Hypertension, Pregnancy-Induced (10) and Hypertension (7).
- −43Match it another way38 name it in the title, 1 in a keyword, and 4 by a synonym or other text the search reads.
- 916The count on this page33 of them list Pre-Eclampsia in their own words; the registry filed them under no condition.
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Status
Who runs them
Assiut University (31) · Cairo University (19) · Assistance Publique - Hôpitaux de Paris (16) · Ohio State University (11) · Saint Thomas Hospital, Panama (11) · University of Oxford (11) · Oslo University Hospital (8) · Anna Stanhewicz, PhD (8)
What is being tested here
Drugs under test in Pre-Eclampsia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Aspirin | 16 | 13 | 50 |
| Labetalol | 4 | 3 | 15 |
| Furosemide | 3 | 1 | 7 |
| Metformin | 3 | 3 | 7 |
| Nifedipine | 2 | 2 | 11 |
| Enoxaparin | 2 | 4 | 6 |
| Cholecalciferol | 2 | 0 | 4 |
| Eplerenone | 2 | 0 | 3 |
| Magnesium Sulfate | 1 | 2 | 15 |
| Norepinephrine | 1 | 0 | 6 |
Drug classes tested here NSAIDs 16 open · Diuretics 5 open · Beta blockers 4 open · Mineralocorticoid receptor antagonists (MRAs) 4 open · Loop diuretics 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Oct 2027Cardiovascular Protection After Preeclampsia With Enalapril · Phase 3 · Women and Infants Hospital of Rhode Island
- Nov 2026Ultrasonographical Assessment of Airway Indices in Pregnancy · South Valley University
- Nov 2026Preeclampsia and Fetal Heart Malformations: Looking to Maternal Heart · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Nov 2026Predictors of Aspirin Failure in Preeclampsia Prevention · Rockefeller University
- Nov 2026Comparison of High- Versus Low-Dose Aspirin for Pregnancy Outcomes in Women at High Risk of Preeclampsia · Medicare Hospital (Pvt) Limited
- Nov 2026Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients · Assiut University
- Nov 2026Multicenter Prospective Cohort Study of Twin Maternal-Child Dyads in China · Peking University Third Hospital
- Dec 2026A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia · Oregon Health and Science University
- Dec 2026Preeclampsia and Defective Placentation in Oocyte Donation: Importance of HLA-C and KIR · Universitair Ziekenhuis Brussel
- Dec 2026Endothelial Dysfunction for Prognosis In Patients With preeClampSia · Heidelberg University
Who these studies take
Of the 162 Pre-Eclampsia studies recruiting now, 81 (50%) set no upper age limit and 80 (49%) stop at 75 or younger. 18 (11%) take children under 18. 157 (97%) are for women only and 0 (0%) for men only; 60 (37%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 8 (5%) | 1 (1%) |
| 18 | 147 (91%) | 4 (2%) |
| 30 | 160 (99%) | 4 (2%) |
| 40 | 155 (96%) | 4 (2%) |
| 50 | 107 (66%) | 4 (2%) |
| 65 | 87 (54%) | 3 (2%) |
| 75 | 82 (51%) | 3 (2%) |
| 85 | 82 (51%) | 3 (2%) |
Across all 916 studies, recruiting or not: 55% stop at 75 or younger and 55% at 65; 20% take children; 95% are for women only and <1% for men only; 39% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Pre-Eclampsia studies take
Of 35 phase 4 interventional studies under Pre-Eclampsia, half reached primary completion within 29 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 25 mo11–34 · 20 studies | — | — |
| Phase 4 | 29 mo17–35 · 35 studies | — | — |
| Interventional, no phase | 24 mo9–43 · 176 studies | — | 24 mo9–43 · 171 studies |
| Observational | 30 mo11–56 · 200 studies | — | 27 mo11–56 · 191 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting6
- Estimated Risk of Preeclampsia in the First Trimester and Its Association With Subclinical Atherosclerosis and Cardiovascular Risk in Women With Type 1 DiabetesNov 5, 2026NCT07479329
- Preeclampsia Intervention NetherlandsNov 4, 2026NCT06452498
- Optimizing Preeclampsia Postpartum With Point-of-care UltrasoundNov 2, 2026NCT07167862
- Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood PressureOct 28, 2026NCT07778966
- Oxford Luteal Dysfunction and Placental Insufficiency StudyOct 22, 2026NCT07072052
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- MH-Rx Study (Baby on Board: Check-in on You, Your Medication, & Your Blood Pressure)Oct 14, 2026NCT07842341
Stopped2
- mHealth for Hypertensive Disorder of PregnancyTerminatedNov 2, 2026NCT05995106
- MR and Inflammation After PreeclampsiaWithdrawnOct 29, 2026NCT07345845
Newly registered3
- Efficacy Of Supplemental L-Arginine in Preventing Preeclampsia in Pregnant WomenNov 3, 2026NCT07912866
- Blood Pressure Goal in Preterm PreeclampsiaOct 26, 2026NCT07894705
- Retinal and Choroidal Microcirculation in Preeclampsia: An OCTA StudyOct 14, 2026NCT07874191
Studies
Recruiting first, then most recently updated. Showing 50 of 916. Browse all 916 → or search them.
- Advancing Stillbirth Prevention Through Innovative Risk Evaluation (ASPIRE) Clinical StudyRecruitingNCT076699351 country
- Placental Biology in Health and DiseaseRecruitingNCT074703201 country
- Molecular Study of the Maternal-fetal Interface in Preeclampsia.RecruitingNCT062326681 country
- Exercise to Improve Heart and Metabolic Health After Childbirth in Women at High Risk for PreeclampsiaRecruitingNCT07921173Not applicable1 country
- Furosemide vs Placebo in Severe Preeclampsia PostpartumNot yet recruitingNCT07648251Phase 21 country
- Estimated Risk of Preeclampsia in the First Trimester and Its Association With Subclinical Atherosclerosis and Cardiovascular Risk in Women With Type 1 DiabetesRecruitingNCT074793291 country
- Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)RecruitingNCT07098975Phase 21 country
- Preeclampsia Intervention NetherlandsRecruitingNCT06452498Phase 31 country
- A Study to Lower Blood Pressure One Year After Childbirth in Women Who Had PreeclampsiaNot yet recruitingNCT06798649Not applicable
- Biomarkers in Management of Post Partum PreeclampsiaNot yet recruitingNCT07478055Phase 41 country
- Optimizing Preeclampsia Postpartum With Point-of-care UltrasoundRecruitingNCT07167862Phase 41 country
- The Efficacy of Aspirin Combined With Hydroxychloroquine Treatment in High Risk Pregnancies for PreeclampsiaRecruitingNCT05287321Phase 31 country
- Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood PressureRecruitingNCT07778966Not applicable1 country
- Antidepressant Therapy for Improved Blood Vessel Health After PreeclampsiaRecruitingNCT07715669Early Phase 11 country
- Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIALRecruitingNCT06468202Phase 41 country
- Blood Pressure Goal in Preterm PreeclampsiaNot yet recruitingNCT078947051 country
- Usability Evaluation of Gen AI-based Nutrition Chatbot for Pregnant WomenNot yet recruitingNCT07458997Not applicable1 country
- AtorvaStatin Postpartum and Reduction of Cardiovascular risKRecruitingNCT06632379Phase 41 country
- Ravulizumab in Pregnancies Complicated by Severe Hypertensive DisordersRecruitingNCT06333652Phase 21 country
- Oxford Luteal Dysfunction and Placental Insufficiency StudyRecruitingNCT070720521 country
- Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of PregnancyRecruitingNCT07238400Phase 21 country
- MumCare: Mum's Cardiovascular Health for LifeEnrolling by invitationNCT05835596Not applicable1 country
- Retinal and Choroidal Microcirculation in Preeclampsia: An OCTA StudyRecruitingNCT078741911 country
- MH-Rx Study (Baby on Board: Check-in on You, Your Medication, & Your Blood Pressure)RecruitingNCT07842341Not applicable1 country
- Prevalence of Asymptomatic Bacteriuria Among Pregnant Women With Pre-eclampsia in Women Health Hospital Assiut UniversityNot yet recruitingNCT07866196
- Role of Postpartum Furosemide in Recovery of Patients With Severe PreeclampsiaRecruitingNCT07861685Not applicable1 country
- MitoQ to Improve Vascular Funciton in PreeclampsiaRecruitingNCT07229261Not applicable1 country
- Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) DisparitiesNot yet recruitingNCT06915428Not applicable1 country
- Gestational Changes in Hemodynamics and Respiratory Mechanics in Association With Pre-EclampsiaNot yet recruitingNCT076959091 country
- PI4 - A Trial Assessing Metformin to Prolong Gestation in Preterm PreeclampsiaRecruitingNCT06033131Phase 33 countries
- Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and InnovationRecruitingNCT078448761 country
- Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy OutcomesNot yet recruitingNCT07841197
- Ophthalmic Artery Doppler in the Puerperium After Hypertensive Disorders of Pregnancy (OPHELIA-PP)Not yet recruitingNCT078417951 country
- Treatment With Aspirin After Preeclampsia: TAP TrialRecruitingNCT06281665Phase 41 country
- Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST TrialNot yet recruitingNCT07746271Phase 31 country
- Modelization of Early Endometrial-trophoblast Molecular InteractionNot yet recruitingNCT07825649Not applicable1 country
- Mindfulness and Wearable Biosensors to Prevent Hypertensive Disorders of PregnancyRecruitingNCT07218237Not applicable1 country
- Physical Activity to Mitigate PreEclampsia RiskRecruitingNCT06319014Not applicable1 country
- APPLE: Aspirin to Prevent Pregnancy Loss and PreeclampsiaRecruitingNCT06408181Phase 31 country
- Internal Jugular Vein Collapsibility Index for Volume Status Assessment in Preeclampsia in Correlation With Normotensive ParturientsRecruitingNCT077862461 country
- PROTECT-Africa: Biomarker Validation for Preeclampsia TriageRecruitingNCT078104391 country
- Exploring the Effect of Discharge Education, Blood Pressure Cuffs, and Postpartum Bracelets to Improve Health Among Newly Diagnosed Gestational Hypertension and Preeclampsia Patients During the Postpartum Period.Not yet recruitingNCT07807098Not applicable
- Hyperspectral Imaging for Prediction of PreeclampsiaRecruitingNCT071062941 country
- Endothelial Dysfunction for Prognosis In Patients With preeClampSiaRecruitingNCT069124771 country
- Improve Awarness of Preeclampsia Among Pregnant WomenNot yet recruitingNCT07805239
- Vagal Stimulation Therapy and PreeclampsiaRecruitingNCT06953115Not applicable1 country
- Dexamethasone Versus Ondansetron for Preventing Post-Spinal Hypotension in PreeclampsiaNot yet recruitingNCT07793760Phase 4
- A Feasibility Study to Evaluate the Safety of the KNP-1000 Apheresis System in Severe PreeclampsiaNot yet recruitingNCT06580405Not applicable
- A Study to Find and Confirm Blood-based Markers (Called Proteins) That May Show Early Heart Changes in Women With Preeclampsia, Even Before Symptoms Appear, and the Use of Heart Ultrasound (Echocardiography) to Look at Patterns of How the Heart Changes During Pregnancy in Women With PreeclampsiaRecruitingNCT074638981 country
- Comparison of High- Versus Low-Dose Aspirin for Pregnancy Outcomes in Women at High Risk of PreeclampsiaRecruitingNCT07779057Phase 41 country