An interventional study of Deprescribing antihypertensives without a taper in Hypertension (HTN), sponsored by University of Alberta. Completed at 2 sites in Canada. Open to participants aged 80 Years and older. Per ClinicalTrials.gov, last updated 2026-10-22.
Sponsored by University of Alberta · Not applicable, Interventional, and Treatment
Blood pressure medications may provide limited benefit and cause side effects in frail older adults. It is unclear how best to stop these medications. Guidelines often recommend gradually reducing the dose, but this process can be time-consuming. This study examined the feasibility of stopping blood pressure medications without gradually reducing the dose in long-term care residents with low blood pressure. Eligible residents had their medication stopped and were monitored for four weeks.
6,834 studies on the registry are indexed under Hypertension; 971 are open to participants now.
This study's enrollment of 11 is below the median of 90 across 5,095 interventional studies indexed under Hypertension.
Browse Hypertension studies →University of Alberta is the lead sponsor of 819 studies on the registry; 166 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 3 (60%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Eligible long-term care residents had one blood pressure medication discontinued without gradually reducing the dose.
Other: Deprescribing antihypertensives without a taper
Discontinuation of one antihypertensive medication without gradually reducing the dose.
Successful Antihypertensive Deprescribing
Proportion of participants who discontinued one antihypertensive medication without tapering and remained off that medication for four weeks.
Time frame: In the four weeks after medication discontinuation
Change in Systolic and Diastolic Blood Pressure
Change in systolic and diastolic blood pressure from baseline to the end of the four-week follow-up period.
Time frame: Baseline and four weeks after medication discontinuation
Change in As-Needed Medication Use
Change in the monthly number of as-needed medication administrations before and after stopping antihypertensive medication
Time frame: Three months before and four weeks after medication discontinuation
Change in Number of Falls
Change in the number of falls before and after stopping antihypertensive medication
Time frame: Six months before and four weeks after medication discontinuation
Change in Meal Intake
Change in the percentage of meals consumed before and after stopping antihypertensive medication, assessed using categories of 0-25%, 26-50%, 51-75%, and over 75%
Time frame: Four weeks before and four weeks after medication discontinuation
Ran from Jun 2025 to primary completion in Nov 2025, 5 months.
Of 1,339 non-industry interventional studies with no phase under Hypertension, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 42. This study's 5 months is below that.
Counting every sponsor, half of 1,433 studies reached it within 23 months; a quarter within 9 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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