ClinicalTrials.gg
CompletedNCT07870369CVD-PHPTUpdated Oct 13, 2026

Cardiovascular Risk in Patients With Primary Hyperparathyroidism

An observational study in Heart Failure, Atrial Fibrillation (AF) and Arrhythmia, sponsored by Medical University of Sofia. Completed at 1 site in Bulgaria. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-13.

Sponsored by Medical University of Sofia · Observational

Updated Oct 13, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
77
Ages
18 Years and older
Sex
All
01

Study summary

Patients with primary hyperparathyroidism versus healthy controls assessed for their cardiovascular risk and overt CVD

Read the detailed description

A cross-sectional, non-interventional single-center study includding 54 patients with primary hyperparathyroidism and 23 healthy controls. The participants have been examined clinically and with certain instrumental investigations: laboratorys, ECG, Holter ECG echocardiography. We have evaluated comparatively the cardiovascular risk and the over cardiac events in both groups and sought for determinants of cardiaovascular complications in primary hyperparathyoridism.

02

Conditions studied

  • Heart Failure
  • Atrial Fibrillation (AF)
  • Arrhythmia
  • Coronary Artery Disease
  • Hypertension (HTN)

Keywords

  • primary hyperparathyoidism
  • cardiovascular
  • risk
  • arrhythmias
  • hypertension
  • heart failure
03

In context

Heart Failure

5,803 studies on the registry are indexed under Heart Failure; 1,222 are open to participants now.

This study's enrollment of 77 is below the median of 200 across 1,719 observational studies indexed under Heart Failure.

Browse Heart Failure studies →

Lead sponsor

Medical University of Sofia is the lead sponsor of 12 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

54 patients with PHPT and 23 controls

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

confirmed primary hyperparathyroidism

Exclusion criteria

Exclusion Criteria:

secondary hyperparathyroidism

05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
77 participants (actual)
Patient registry
No

Groups and cohorts

  • Primary hyperparathyroidism

    Patients with primary hyoerparathyroidism

  • Control group

    Patients withthout primary pyperparathyroidism mateched for age and sex

06

What researchers measure

Primary outcomes

  1. Cardiovascular events

    Any cardiac events

    Time frame: 24 months

  2. Cardiovascular complications

    Any cardiovascular disease

    Time frame: january 1st 2023 - december 31st 2025

07

Study locations

1 site
  • KPVB
    Sofia, 1680, Bulgaria
08

References and documents

Individual participant data

Plan to share: Yes

Supporting information: Study protocol, Informed consent form

Time frame: 31 Aug 2026

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2023 to primary completion in Dec 2025, 35 months.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 6, 2026
First posted
Oct 13, 2026
StartActual
Jan 1, 2023
Primary completionActual
Dec 31, 2025
CompletionActual
Dec 31, 2025
Last update
Oct 13, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Oct 13, 2026
Show all 1 update
  1. Oct 13, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07870369
Lead sponsor
Medical University of Sofia
Responsible party
Stefan Naydenov Naydenov (Associate professor, PhD, Medical University of Sofia) — Principal investigator
First posted
Oct 13, 2026
Start date
Jan 1, 2023
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025
Last update
Oct 13, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion