Novartis: Hypertension trials

The registry lists 227 Hypertension studies with Novartis as lead sponsor. 4 are open to participants now and 88 have results posted.

Phase 1 18Phase 2 31Phase 3 109Phase 4 67No phase 4(a study in two phases counts in both)

Studies

Page 1 of 3. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• HJB647 Phase 1b Study in Japanese Healthy Participants With Elevated Blood Pressure and Patients With HypertensionRecruitingNCT07644364Phase 1
• A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant HypercholesterolemiaRecruitingNCT07610278Phase 2
• An Open-label Extension Safety and Efficacy Study of QCZ484 in Hypertensive Patients.RecruitingNCT07543120Phase 2
• A Real-world Study of the Effectiveness of Angiotensin Receptor-Neprilysin Inhibitor Therapy in Hypertensive Patients in the United Arab EmiratesRecruitingNCT07465666
• An Efficacy, Safety, Tolerability and Dose Finding Study of XXB750 in Resistant Hypertension Patients.CompletedNCT05562934Phase 2Results posted
• A Dose Finding Study to Assess the Effect of LIK066 Compared to Placebo or Empagliflozin in Patients With Type 2 Diabetes Mellitus and Heart FailureTerminatedNCT03152552Phase 2Results posted
• Safety and Efficacy Study of LHW090 in Resistant Hypertension PatientsCompletedNCT02515331Phase 2Results posted
• Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to OlmesartanCompletedNCT01876368Phase 3Results posted
• A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With HypertensionCompletedNCT01870739Phase 2Results posted
• Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With HypertensionCompletedNCT01692301Phase 2Results posted
• Assessment of LCZ696 and Valsartan in Asian Patients With Salt-sensitive HypertensionCompletedNCT01681576Phase 2Results posted
• Efficacy and Safety of LCZ696 200 mg + Amlodipine 5 mg in Comparison With Amlodipine 5 mg in Hypertensive Patients Not Responding to AmlodipineCompletedNCT01663233Phase 3Results posted
• Safety and Tolerability and Efficacy of LCZ696 in Japanese Severe Hypertensive PatientsCompletedNCT01646671Phase 3Results posted
• Evaluation of the Metabolic Effects of LCZ696 and Amlodipine in Obese Hypertensive SubjectsCompletedNCT01631864Phase 2Results posted
• Efficacy, Safety and Tolerability of Multiple Doses of Valsartan in Children With Hypertension With or Without CKDCompletedNCT01617681Phase 3Results posted
• Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Elderly Patients With Essential HypertensionCompletedNCT01615198Phase 3Results posted
• Evaluation of Drug-drug Interaction Between LCZ696 and Sildenafil in Subjects With Mild to Moderate HypertensionCompletedNCT01601470Phase 2Results posted
• Safety and Tolerability and Efficacy of LCZ696 in Japanese Hypertensive Patients With Renal DysfunctionCompletedNCT01593787Phase 3Results posted
• 8-week Randomized, Open-label Study to Evaluate Food Effect on Efficacy and Safety of Oral Aliskiren 300 mg in Patients With HypertensionCompletedNCT01570686Phase 4Results posted
• Study to Evaluate the Efficacy and Safety of the Combination of Valturna and Amlodipine or Valturna and Chlorthalidone Versus Valturna Alone in Patients With Stage 2 Hypertension and DiabetesTerminatedNCT01368536Phase 4Results posted
• Safety and Tolerability of Valsartan in Children 6 to 17 Years of AgeCompletedNCT01365481Phase 3Results posted
• Sodium Excretion of LCZ696 in Patients With Hypertension; Heart Failure and Healthy VolunteersCompletedNCT01353508Phase 2Results posted
• An 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic HypertensionCompletedNCT01281306Phase 2Results posted
• A Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential HypertensionCompletedNCT01256411Phase 2Results posted
• Efficacy and Safety of LCZ696 Compared to Placebo in Patients With Essential HypertensionCompletedNCT01193101Phase 2Results posted
• ALiskiren or Losartan Effects on bioMARKers of Myocardial RemodelingCompletedNCT01176032Phase 4Results posted
• Effectiveness of Valsartan/Amlodipine (EXforge®) and Nifedipine treAtment coMparison in Treating Chinese Hypertensive PatientsCompletedNCT01167153Phase 4Results posted
• An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of AgeCompletedNCT01151410Phase 3Results posted
• Safety and Efficacy of Aliskiren in Pediatric Hypertensive Patients 6-17 Years of AgeCompletedNCT01150357Phase 3Results posted
• Assessment of Aliskiren/Amlodipine and Amlodipine on Ankle Foot Volume (AFV) in Patients With HypertensionTerminatedNCT01080768Phase 2Results posted
• To Demonstrate Non-inferiority of Combination of 5 mg Amlodipine/ 80 mg Valsartan to 160 mg Valsartan AloneCompletedNCT01070043Phase 4Results posted
• Efficacy and Safety of Valsartan/Amlodipine in Patients With Mild to Moderate Essential HypertensionCompletedNCT01001572Phase 3Results posted
• Aliskiren/Amlodipine/Hydrochlorothiazide (HCTZ) Versus Aliskiren/Amlodipine in US Minority Patients With Stage II Systolic HypertensionCompletedNCT00942994Phase 4Results posted
• Valsartan/Amlodipine As Compared to Losartan Treatment in Stage 2 Systolic HypertensionCompletedNCT00931710Phase 4Results posted
• Aliskiren and Valsartan vs Valsartan Alone in Patients With Stage II Systolic Hypertension and Type II Diabetes MellitusCompletedNCT00927394Phase 4Results posted
• Valsartan Intensified Primary Care Reduction of Blood Pressure StudyCompletedNCT00902304Phase 4Results posted
• Safety and Efficacy of Aliskiren + Hydrochlorothiazide (± Amlodipine 5 mg) in Patients With Moderate HypertensionCompletedNCT00867490Phase 3Results posted
• Efficacy and Safety of Aliskiren 300 mg Compared to Telmisartan 80 mg After 1 Week of Treatment WithdrawalCompletedNCT00865020Phase 4Results posted
• Efficacy and Safety of Aliskiren Administered in Combination With Amlodipine Versus Amlodipine Alone in African American Patients With Stage 2 HypertensionCompletedNCT00853957Phase 4Results posted
• Efficacy and Safety of the Combination of Aliskiren (300 mg) and Amlodipine (10 mg) Compared to Amlodipine (10 mg) Monotherapy in Patients With Moderate to Severe HypertensionCompletedNCT00841672Phase 3Results posted
• A Study to Evaluate the Safety/Tolerability and Pharmacokinetics of Aliskiren in Hypertensive Pediatric and Adolescent Patients 6-17 Years of AgeCompletedNCT00834041Phase 1/2Results posted
• Efficacy and Safety of Aliskiren in Patients With Mild to Moderate Hypertension During ExerciseCompletedNCT00819767Phase 2Results posted
• A Study to Evaluate the Efficacy and Safety of LCI699 Compared to Placebo in Participants With Resistant HypertensionCompletedNCT00817635Phase 2Results posted
• A Study to Evaluate the Effects of LCI699 on Cortisol in Participants With HypertensionCompletedNCT00817414Phase 2Results posted
• 8 Weeks Study to Evaluate the Efficacy and Safety of Valsartan in Combination With Aliskiren Compared to Valsartan Alone in Patients With Stage 2 HypertensionCompletedNCT00809926Phase 4Results posted
• Clevidipine in the Treatment of Blood Pressure in Patients With Acute Heart Failure (PRONTO)CompletedNCT00803634Phase 3Results posted
• Clevidipine Bolus Administration in the Treatment of Hypertensive Patients Undergoing Cardiac Surgery (SPRINT)CompletedNCT00799604Phase 2Results posted
• Aliskiren and the Calcium Channel Blocker Amlodipine Combination as an Initial Treatment Strategy for HypertensionCompletedNCT00797862Phase 3Results posted
• Aliskiren Plus HCTZ Compared to Aliskiren in Metabolic Syndrome Patients With Stage 2 Systolic HypertensionCompletedNCT00797316Phase 4Results posted
• Aliskiren HCTZ Compared to Amlodipine in Patients With Stage 2 Systolic Hypertension and Diabetes MellitusCompletedNCT00787605Phase 4Results posted
• Study to Evaluate the Efficacy and Safety of Combination Aliskiren/Amlodipine in Patients With Hypertension Not Adequately Responding to Amlodipine AloneCompletedNCT00778921Phase 3Results posted
• Study to Evaluate the Efficacy and Safety of Combination Aliskiren/Amlodipine in Patients Not Adequately Responding to Aliskiren AloneCompletedNCT00777946Phase 3Results posted
• Study of the Efficacy and Safety of Aliskiren HCTZ vs Ramipril in Obese Patients (BMI ≥ 30) With Stage 2 HypertensionCompletedNCT00772577Phase 4Results posted
• Efficacy and Safety of Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Moderate-severe HypertensionCompletedNCT00765674Phase 3Results posted
• Blood Pressure Lowering of Aliskiren HCTZ Compared to HCTZ in Stage 2 Systolic Hypertension in Older PopulationCompletedNCT00760266Phase 4Results posted
• Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Amlodipine in Essential HypertensionCompletedNCT00739973Phase 3Results posted
• Blood Pressure Lowering of Aliskiren Hydrochlorothiazide (HCTZ) Versus Amlodipine in Stage 2 Hypertension in African AmericansCompletedNCT00739596Phase 4Results posted
• Efficacy and Safety of Aliskiren 75 mg, 150 mg, and 300 mg in Elderly Patients With Essential Hypertension When Given With a Light Meal in a 8 Week Placebo-controlled StudyCompletedNCT00706134Phase 3Results posted
• Efficacy and Safety of the Combination Aliskiren (300 mg) and Hydrochlorothiazide (25mg) to Aliskiren (300mg) Monotherapy in Patients With Staged II HypertensionCompletedNCT00705575Phase 3Results posted
• Efficacy of a Combination of Amlodipine/Valsartan on 24H Blood Pressure Control With One Nocturnal or Diurnal Intake a DayCompletedNCT00700271Phase 4Results posted
• Safety, Tolerability, and Efficacy of Once Daily Amlodipine/Valsartan 5/80 as Compared to Amlodipine/Valsartan 5/40 or to Amlodipine 5 mg Monotherapy in Patients 65 Years of Age and Older With Essential HypertensionCompletedNCT00699192Phase 3Results posted
• Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Compared to Valsartan Monotherapy or Hydrochlorothiazide Monotherapy in Elderly (>70) With Mild-moderate Hypertension.CompletedNCT00698646Phase 4Results posted
• Effect of the Fixed Dose Combination Amlodipine/Valsartan on Central Aortic Blood Pressure in Uncontrolled Essential Hypertension With Amlodipine 5 mgCompletedNCT00687973Phase 4Results posted
• A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential HypertensionCompletedNCT00667719Phase 3Results posted
• The Effects of Moderate vs. Aggressive Treatment With Valsartan + Amlodipine on Patients With Hypertension Uncontrolled by Angiotensin-Receptor Blocker (Herein, ARB) MonotherapyCompletedNCT00666536Phase 4Results posted
• Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE)CompletedNCT00666328Phase 3Results posted
• A Clinical Study to Evaluate Renal Hemodynamic Responses to Aliskiren in Patients With Type 2 Diabetes MellitusCompletedNCT00660309Phase 4Results posted
• A Study Evaluating the Gastrointestinal (GI) Safety and Tolerability of Aliskiren Compared to Ramipril in Essential HypertensionCompletedNCT00631917Phase 4Results posted
• Efficacy and Safety of LCZ696A in Patients With Essential HypertensionCompletedNCT00549770Phase 2Results posted
• Efficacy and Safety of Aliskiren/Ramipril/Amlodipine Compared With Ramipril/Amlodipine and Aliskiren/Amlodipine in Patients With Metabolic SyndromeTerminatedNCT00542269Phase 4Results posted
• Safety and Efficacy of Aliskiren 300 mg, 150 mg and 75 mg in Patients With Essential Hypertension Compared to Ramipril 5 mgCompletedNCT00529451Phase 3Results posted
• Efficacy and Safety of Valsartan and Amlodipine (± HCTZ) in Adults With Moderate, Inadequately Controlled HypertensionCompletedNCT00523744Phase 3Results posted
• The Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients With Hypertension and Diastolic DysfunctionCompletedNCT00523549Phase 4Results posted
• Effects of Aliskiren and Amlodipine on the Renin-Angiotensin System (RAS) and Lipid/Carbohydrate Metabolism in Obese Patients With HypertensionTerminatedNCT00498433Phase 2Results posted
• A Study to Evaluate the Long-term Use of Valsartan in Children 6 Months to 5 Years Old With HypertensionCompletedNCT00457626Phase 3Results posted
• Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular HypertrophyCompletedNCT00446563Phase 3Results posted
• Extension Study to Assess Long Term Safety, Tolerability, and Efficacy of Valsartan and Enalapril Combined and Alone in Children With HypertensionCompletedNCT00446511Phase 3Results posted
• Effect of High and Low Sodium Diets on Blood Pressure in Hypertensive Patients Treated With AliskirenCompletedNCT00441064Phase 4Results posted
• Safety/Efficacy of Valsartan/Hydrochlorothiazide Combination Compared to Hydrochlorothiazide in Obese Hypertensive AdultsCompletedNCT00439738Phase 4Results posted
• Dose Response of Valsartan on Sitting Systolic Blood Pressure in Children 6 Months - 5 Years of Age With High Blood PressureCompletedNCT00435162Phase 3Results posted
• Effect of Valsartan Compared to Enalapril on Sitting Systolic Blood Pressure in Children With High Blood PressureCompletedNCT00433836Phase 3Results posted
• Efficacy and Safety of Valsartan and Amlodipine in Patients With Essential HypertensionCompletedNCT00425373Phase 2/3Results posted
• Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic SyndromeCompletedNCT00417170Phase 2Results posted
• Efficacy/Safety of Valsartan Plus Amlodipine and Valsartan Alone in Patients With HypertensionCompletedNCT00413413Phase 3Results posted
• Efficacy/Safety of Valsartan Plus Amlodipine and Amlodipine Alone in Patients With HypertensionCompletedNCT00413049Phase 3Results posted
• An Assessment of Long Term Safety of the Combination of Aliskiren / Amlodipine in Patients With High Blood PressureCompletedNCT00402103Phase 3Results posted
• Safety and Efficacy of Valsartan vs Atenolol and Hydrochlorothiazide Combination on Blood Flow in Hypertensive PatientsCompletedNCT00396656Phase 3Results posted
• A Safety and Tolerability Study of the Combination of Aliskiren/Valsartan in Patients With High Blood Pressure, Followed by Long-term Safety and Tolerability of Aliskiren, Valsartan and Hydrochlorothiazide.CompletedNCT00386607Phase 3Results posted
• A Safety and Efficacy Trial of Aliskiren 150mg , 300 mg Compared to Ramipril 5mg, 10mg in the ElderlyCompletedNCT00368277Phase 3Results posted
• Aliskiren in Combination With Losartan Compared to Losartan on the Regression of Left Ventricular Hypertrophy in Overweight Patients With Essential HypertensionCompletedNCT00219141Phase 3Results posted
• Efficacy and Safety of Valsartan Versus Amlodipine in Postmenopausal Women With HypertensionCompletedNCT00171054Phase 4Results posted
• Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic HypertensionTerminatedNCT00170950Phase 3Results posted
• A Study to Evaluate the Safety of QCZ484 in Healthy and Mild Hypertensive SubjectsCompletedNCT06905327Phase 1
• A Study to Identify an Optimal Dose of QCZ484 in Mild to Moderate Hypertensive PatientsActive, not recruitingNCT06857955Phase 2
• A Real-world Study of the Safety of Hypertension Medication Therapy in Japanese Patients With Naïve HypertensionCompletedNCT06683768
• Study of Efficacy and Safety of LCZ696/Amlodipine in Grade 1 and 2 Hypertension Patients Uncontrolled by LCZ696 MonotherapyCompletedNCT06236061Phase 3
• Special Drug Use Surveillance of Entresto Tablets (Hypertension)CompletedNCT05976230
• Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHFWithdrawnNCT04592380Phase 3
• To Evaluate Pharmacokinetics of LFF269 in Healthy Volunteers and Patients With HypertensionTerminatedNCT02047656Phase 1
• Aliskiren Study of Safety and Efficacy in Senior HypertensivesWithdrawnNCT01922141Phase 4