Drug

Spironolactone clinical trials

Also written Aldactone and SC 9420.

studies test it: 176
open now: 26
in phase 3: 37
first study started: 2002

Keep track of what changes. Save the Spironolactone studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.

Watch these studies

How studies write it

Studies that test it under each name

Name

Spironolactone: 121
Spironolactone (drug): 7
Spironolactone 25mg: 6
Spironolactone 100mg: 5
Spironolactone 50 MG: 3

Brand

Aldactone: 39

Development codes

SC 9420: 2

Written with another drug

Spironolactone + Dapagliflozin: 2
spironolactone + furosemide: 2
metolazone/spironolactone: 2

Studies by the year they started

171 studies that test it; most in 2013 (13); 2 more planned to start later

Studies that test Spironolactone, by start year
Year	Studies
2002	1
2003	3
2004	7
2005	7
2006	6
2007	6
2008	7
2009	7
2010	12
2011	7
2012	7
2013	13
2014	12
2015	9
2016	5
2017	5
2018	8
2019	7
2020	8
2021	4
2022	10
2023	5
2024	5
2025	4
2026	6

By phase

A phase 1/2 study counts in both.

Early Phase 1: 3
Phase 1: 15
Phase 2: 46
Phase 3: 37
Phase 4: 62
No phase: 26

What it is tested for

Each study’s main condition, where its own words name it.

Heart Failure: 25
Hypertension: 15
Kidney Failure, Chronic: 12
Atrial Fibrillation: 8
Polycystic Ovary Syndrome: 6
Pulmonary Arterial Hypertension: 5
Diabetic Nephropathies: 4
Acute Kidney Injury: 4
Kidney Diseases: 3
Heart Failure, Diastolic: 3
Acne Vulgaris: 2
Myocardial Infarction: 2

Who runs them

Industry 10 · Other 166

Brigham and Women's Hospital (5) · University of Virginia (4) · Vanderbilt University (3) · Instituto Nacional de Cardiologia Ignacio Chavez (3) · Yale University (2) · University of Pennsylvania (2) · Sarfez Pharmaceuticals, Inc. (2) · Emory University (2)

Often tested with

Tested in the same studies.

Eplerenone (5) · Furosemide (5) · Amiloride (5) · Torsemide (4) · Metformin (4) · Carvedilol (3) · Bisoprolol (3) · Dapagliflozin (2)

Related medicines

As reviewed, each with the page that says it.

One of Diuretics source
One of Mineralocorticoid Receptor Antagonists source

Studies

Open first, then newest update. How each study uses Spironolactone is read from its arms, and is right about nine times in ten.

Testing it · 176

See all 176 studies that test Spironolactone →

Given in every arm · 9 — Spironolactone is usual care beside what is tested

As the comparator · 17 — what is tested is compared with Spironolactone

Codes

What other systems call Spironolactone · ClinicalTrials.gg INT008232

MeSH (NLM) D013148SpironolactoneConfirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA) 27O7W4T232SPIRONOLACTONEConfirmed FDA, NLM, Wikidata
RxNorm 9997Confirmed FDA, Wikidata
Wikidata Q422188spironolactoneConfirmed FDA, NLM, Wikidata
NCI Thesaurus C840SpironolactoneOne source FDA
DrugBank DB00421One source Wikidata

System	Code	Name there	Checked by
MeSH (NLM)	D013148	Spironolactone	Confirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA)	27O7W4T232	SPIRONOLACTONE	Confirmed FDA, NLM, Wikidata
RxNorm	9997	—	Confirmed FDA, Wikidata
Wikidata	Q422188	spironolactone	Confirmed FDA, NLM, Wikidata
NCI Thesaurus	C840	Spironolactone	One source FDA
DrugBank	DB00421	—	One source Wikidata

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.