Drug
Lidocaine clinical trials
Also written Xylocaine, Lidoderm, ALGRX 3268 and Akten.
Includes 47 studies of Lidoderm.
Counted the way a researcher would: Lidocaine with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses Lidocaine is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Lidocaine studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
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Approvals
The first approval found in each region, with its record
- United States
- 19 Nov 1948 · XYLOCAINE · NDA 006488 (FDA, Drugs@FDA)
- European Union
- 15 Nov 2013 · Fortacin · EMEA/H/C/002693 (EMA; in a combination)
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Name
In one entry with another drug
Given together, or one or the other
Studies by the year they started
1,075 studies that test it; most in 2024 (78); 4 more planned to start later
| Year | Studies |
|---|---|
| 1997 | 1 |
| 2002 | 6 |
| 2003 | 7 |
| 2004 | 11 |
| 2005 | 16 |
| 2006 | 7 |
| 2007 | 23 |
| 2008 | 35 |
| 2009 | 24 |
| 2010 | 40 |
| 2011 | 47 |
| 2012 | 27 |
| 2013 | 38 |
| 2014 | 45 |
| 2015 | 49 |
| 2016 | 65 |
| 2017 | 49 |
| 2018 | 66 |
| 2019 | 67 |
| 2020 | 59 |
| 2021 | 60 |
| 2022 | 51 |
| 2023 | 72 |
| 2024 | 78 |
| 2025 | 70 |
| 2026 | 62 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 61 · Other 1,021
Assiut University (32) · Cairo University (26) · Ain Shams University (21) · Endo Pharmaceuticals (11) · Tanta University (10) · Mayo Clinic (10) · Copka Sonpashan (10) · Duke University (10)
Often tested with
Tested in the same studies.
Dexmedetomidine (59) · Ketamine (41) · Bupivacaine (38) · Epinephrine (31) · Magnesium Sulfate (19) · Fentanyl (18) · Ropivacaine (17) · Propofol (16)
Related medicines
As reviewed, each with the page that says it.
- One of Local anesthetics source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Tested against it · 3 phase 3 studies under way
Lidocaine is the comparator. A study of two new drugs counts under both.
- 1Diphenhydramine · Florida Atlantic University · next primary completion Jun 2027
- 1Ketamine · State University of New York at Buffalo
- 1Fentanyl · State University of New York at Buffalo
Reaching primary completion within a year · 53, 5 in phase 3
Studies that test Lidocaine, phase 3 first.
- Nov 2026Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Suppression After Functional Endoscopic Sinus SurgeryPhase 3 · Assiut University
- Nov 2026Intravenous Lidocaine to Prevent Post-Fundal Pressure Headache During Cesarean SectionPhase 3 · Tanta University
- Dec 2026Intraoperative Lidocaine InfusionPhase 2/3 · Assiut University
- Jul 2027Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi AnalgesiaPhase 3 · GCS Ramsay Santé pour l'Enseignement et la Recherche
- Nov 2027Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing TonsillectomyPhase 3 · Assiut University
- Nov 2026Ketamine and Lidocaine Infusion in Refractory Chronic MigraineEarly Phase 1 · Assiut University
- Nov 2026Intranasal Sphenopalatine Ganglion Blockade for Headaches Following Aneurysmal Subarachnoid HemorrhagePhase 4 · Wright State University
- Nov 2026Intratumoral Lidocaine Injection Before Oropharyngeal Cancer SurgeryPhase 1 · Ryan Carey
- Nov 2026Magnesium Sulfate as an Adjuvant to Lidocaine in MPDS Trigger Point Injections Assessed by VAS and sEMG.Not applicable · Cairo University
- Nov 2026Adding Lidocaine to Custodiol MixturePhase 4 · Fayoum University Hospital
Studies
Open first, then newest update. How each study uses Lidocaine is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 1,082
- Intravenous LIGNOcaine for the POstoperative Sore ThroatNot yet recruitingPhase 4University of MalayaNCT07936825Written as Intravenous lignocaine
- Assessing the Efficacy of a High-Dose Lidocaine-Tetracaine Cream for the Treatment of Peripheral Neuropathic PainNot yet recruitingPhase 1/2Pontificia Universidad Catolica de ChileNCT07396129Written as Lidocaine (23%) + Tetracaine (7%)
- Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) TrialRecruitingPhase 3Monash UniversityNCT05072314Written as lidocaine 2% and 10%
- The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and ItchRecruitingNot applicableAalborg UniversityNCT07203274Written as lidocaine cream
- SPARK Study - Sympathetic Periarterial Radial Block in Healthy VolunteersNot yet recruitingPhase 4Duke UniversityNCT07429292Written as Lidocaine 2%
- REctus Sheath TrialRecruitingPhase 2Duke UniversityNCT07068243Written as 1.0% lidocaine with epinephrine (1:100,000)
- Lidocaine Infiltration and Neuroimmunomodulation in Head and Neck Cancer SurgeryRecruitingPhase 4University Medical Centre LjubljanaNCT07922759Written as Lidocaine HCl 1%
- Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid HemorrhageRecruitingPhase 2The University of Texas Medical Branch, GalvestonNCT07294118Written as Lidocaine
- The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac SurgeryRecruitingPhase 4Vanderbilt University Medical CenterNCT07224711Written as Lidocaine HCl 0.8% in D5W
- Split Face Study of the Duration of Local Anesthetics - Fifth ArmNot yet recruitingPhase 4Weill Medical College of Cornell UniversityNCT07724418Written as Lidocaine HCl/Epinephrine
- Pudendal Nerve Block for Pain Relief During Episiotomy RepairNot yet recruitingNot applicableShaheed Zulfiqar Ali Bhutto Medical UniversityNCT07883473Written as Lignocaine Hydrochloride (Lidocaine Hydrochloride) 2% injection
- Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial FibrillationRecruitingNot applicableChina National Center for Cardiovascular DiseasesNCT07877519Written as Lidocaine
- Lidocaine Patch for Epidural Placement Pain in Laboring WomenRecruitingPhase 3Ohio State UniversityNCT07700108Written as Lidocaine patch 4%
- Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency LaparotomyRecruitingNot applicableCairo UniversityNCT07262242Written as Lidocaine (drug)
- This Study is Comparing Pain Outcomes After Urethral Bulking When Participants Are Randomized to Two Different Pain Medication Regimens.RecruitingPhase 4Northwell HealthNCT07889687Written as Lidocaine injection
- Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain SyndromeRecruitingNot applicableCairo UniversityNCT07572994Written as Lidocaine 2 %
- Focused Versus Multi-Target Trigger Point Injection for Chronic Myofascial Neck PainNot yet recruitingNot applicableMardin Artuklu UniversityNCT07876739Written as Lidocaine 1% Trigger Point Injection
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic SurgeryRecruitingPhase 3Centre Hospitalier Universitaire, AmiensNCT07414706Written as Lidocaine (intravenous infusion, perioperative)
- Pain Control During Hysterosalpingography: A Three-Arm Randomized TrialNot yet recruitingPhase 4Balikesir UniversityNCT07792668Written as Lidocaine %2 ampoule
- Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing TonsillectomyNot yet recruitingPhase 3Assiut UniversityNCT07871266Written as Lidocaine
See all 1,082 studies that test Lidocaine →
Given beside what is tested · 116 — Lidocaine is usual care or a partner of the new treatment
- Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After ThyroidectomyRecruitingPhase 4Pamukkale UniversityNCT07857356Written as Lidocaine %2 ampoule
- Combined Ketorolac and Lidocaine Paracervical Block for Office HysteroscopyEnrolling by invitationPhase 1Icahn School of Medicine at Mount SinaiNCT06653400Written as Lidocaine
- HPV Vaccine Reduced DoseRecruitingPhase 4Emory UniversityNCT06799494Written as Lidocaine injection
- Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the EyesNot yet recruitingPhase 3Prince of Wales Hospital, Shatin, Hong KongNCT07734740Written as Lignocaine 2% concentration solution
- Comparative Study Between Pericapsular Nerve Group Block (PENG) And Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block for Positioning Analgesia Prior to Spinal Anesthesia in Hip Fracture PatientsRecruitingNot applicableAin Shams UniversityNCT07687290Written as Xylocaine 2 %
- Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator PlacementRecruitingPhase 2Rush University Medical CenterNCT07487246Written as Lidocaine HCl 1%
- Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated CoagulationNot yet recruitingPhase 4NYU Langone HealthNCT07644923Written as Lidocaine
- A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox InjectionsNot yet recruitingPhase 4TriHealth Inc.NCT07387315Written as Standard Care for Bladder Botox Injection
- Particulate vs. Non-Particulate Steroid for Sacroiliac Joint InjectionRecruitingPhase 4University of New MexicoNCT06268704Written as 2% Lidocaine HCl Injection
- Lidocaine vs. Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA) in Upper Limb SurgeryRecruitingPhase 4Fatima Memorial HospitalNCT07034300Written as Lidocaine (drug)
- The Effect of Local Infiltration of Tranexamic Acid on Postoperative Blood Loss in Orthognathic SurgeryNot yet recruitingPhase 1/2Ramathibodi HospitalNCT06983886Written as Lidocaine (drug)
- Comparison of Bupivacaine Wound Infiltration Versus Wound Instillation to Minimize Postoperative Pain After Thyroid SurgeryNot yet recruitingPhase 3Assiut UniversityNCT06789575Written as Lidocaine (drug)
- Is Combined Steroid and Sodium Hyaluronate Hydrodilatation More Effective Than Isolated Steroid Hydrodilatation in Treating Patients With Adhesive CapsulitisRecruitingNot applicableTaipei Veterans General Hospital, TaiwanNCT05861570Written as lidocaine hydrochloride
- Comparison of the Effectiveness of Ultrasound-Guided Periradicular Injections in Patients With Lumbar Radicular PainCompletedNot applicableGaziler Physical Medicine and Rehabilitation Education and Research HospitalNCT07771374Written as Lidocaine Hydrochloride 2% Injection Solution
- Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional ProceduresCompletedNot applicableHarbin Medical UniversityNCT07035301Written as Lidocaine Intravenous Infusion
- Comparison of Ketorolac and Dexmedetomidine as An Adjunct to Lignocaine in Prevention of Tourniquet Induced Pain During Intravenous Regional AnesthesiaCompletedNot applicableMayo Hospital LahoreNCT07878962Written as Lidocaine
- Minimal Flow Anesthesia and Infection RiskCompletedNot applicableAnkara City Hospital BilkentNCT07092046Written as Lidocaine %2 ampoule
- Therapeutic Effects Analysis of Pudendal Nerve Infiltrations After 3 Months, in Patients Suffering of Pudendal NeuralgiaCompletedPhase 4Nantes University HospitalNCT00851513Written as Lidocaine
- Reducing Pain During Dental Nerve Block Injections in ChildrenCompletedNot applicableAl-Mustansiriyah UniversityNCT07667725Written as Lidocaine hydrochloride 2% with epinephrine 1:100 000
- Steroids in Occipital Nerve Block for Treatment of HeadacheCompletedPhase 4Mayo ClinicNCT05732532Written as Lidocaine
Showing 20 of 116.
As the comparator · 129 — what is tested is compared with Lidocaine
- Intracuff Dexmedetomidine Versus Alkalinized Lidocaine for Peri-Extubation Cough and Hemodynamic Responses in Elderly PatientsNot yet recruitingNot applicableBeni-Suef UniversityNCT07916246Written as Alkalinized Lidocaine
- Effect of Midazolam Given at Induction on Recall of Propofol Injection PainNot yet recruitingPhase 4Atlas UniversityNCT07912567Written as Lidocaine Hydrochloride 2%
- Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKARecruitingPhase 4Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)NCT07430085Written as Lidocaine (drug)
- Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic CholecystectomyNot yet recruitingPhase 4Assiut UniversityNCT07865455Written as Lidocaine
- Pain Selective Anesthesia for Labor Mobility (PSALM Study): a Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine for Labor Epidural AnalgesiaRecruitingPhase 4Hadassah Medical OrganizationNCT06302257Written as Lidocaine
- Dexmedetomidine Versus Lidocaine for Optic Nerve Sheath Diameter During Craniotomy IntubationNot yet recruitingPhase 4Benha UniversityNCT07820540Written as Lidocaine
- Pain Control for Undergoing Costal Cartilage HarvestingRecruitingPhase 4Mayo ClinicNCT05285566Written as Xylocaine
- Needlefree Lidocaine Application for Vulvar BiopsiesNot yet recruitingNot applicableTufts Medical CenterNCT07793552Written as Lidocaine HCl 1%
- Effect of Preoprative Nebulized Dexmedetomidine Compared to Nebulized Lidocaine in Attenuating Sore Throat Following Tonsillectomy In Childern.RecruitingNot applicableFayoum University HospitalNCT07780760Written as Group L (Lidocaine group)
- Cryotherapy vs Lidocaine Spray for Oral MucositisNot yet recruitingNot applicableHanady Jabbar MahmoodNCT07727031Written as Topical Lidocaine Spray
- Ondansetron Versus Lidocaine for Preventing Pain on Propofol Injection.Not yet recruitingNot applicableMongi Slim HospitalNCT07632144Written as Lidocaine %2 ampoule
- Local Anesthetic Clinical TrialEnrolling by invitationPhase 4Baylor Research InstituteNCT07601750Written as Lidocaine
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal InjectionsEnrolling by invitationPhase 4Harrow IncNCT07456826Written as Lidocaine Hydrochloride Injection 2%
- Continous Infusion of Nefopam for Patients Undergoing PancreatoduodenectomyRecruitingPhase 4Iuliu Hatieganu University of Medicine and PharmacyNCT07423650Written as Lidocaine Infusion
- Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection PainNot yet recruitingNot applicableHayatabad Medical ComplexNCT07422558Written as Lidocaine
- Spinal Morphine or Intravenous Lidocaine in Robot-assisted Upper Urologic SurgeryRecruitingPhase 3Hans BahlmannNCT06349668Written as lidocaine infusion
- Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration RepairsRecruitingPhase 3Florida Atlantic UniversityNCT06910241Written as Lidocaine
- Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.RecruitingPhase 4Instituto Mexicano del Seguro SocialNCT07073846Written as Intravenous Lidocaine infusion + Standard Anesthesia
- Pain Control Alternatives in Pediatric Patients With Distal Radius FracturesRecruitingPhase 3State University of New York at BuffaloNCT07120763Written as Ketamine + Lidocaine
- Comparative Efficacy of Intravenous Labetalol and Lignocaine in Mitigating Hemodynamic Responses to Laryngoscopy During Laparoscopic CholecystectomyRecruitingNot applicableDr. Waseem UllahNCT07192081Written as Lignocaine
Showing 20 of 129.
What changed recently
From the registry's own updates since Oct 16, 2026.
Started recruiting6
- The Role of Janus Kinase (JAK) and Voltage-gated Sodium Channels (Nav) on Pain and ItchNov 9, 2026NCT07203274
- REctus Sheath TrialNov 6, 2026NCT07068243
- The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac SurgeryNov 2, 2026NCT07224711
- Effect of Opioid-sparing Anesthesia on Quality of Recovery After Emergency LaparotomyOct 22, 2026NCT07262242
- Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain SyndromeOct 21, 2026NCT07572994
Show 1 moreShow fewer
- Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic SurgeryOct 16, 2026NCT07414706
Newly registered8
- Intravenous LIGNOcaine for the POstoperative Sore ThroatNov 13, 2026NCT07936825
- Lidocaine Infiltration and Neuroimmunomodulation in Head and Neck Cancer SurgeryNov 6, 2026NCT07922759
- Ropivacaine Alone Versus Ropivacaine Plus Lidocaine With or Without Epinephrine for Supraclavicular Brachial Plexus Block in Upper Limb Orthopedic SurgeryOct 30, 2026NCT07907666
- Comparison of Lidocaine With and Without Adrenaline for Reducing EcchymosisOct 27, 2026NCT07897201
- Preoperative Nebulized Lignocaine Versus Nebulized Dexmedetomidine for Blunting the Pressor Response to Laryngoscopy and Intubation in Controlled Hypertensive PatientsOct 27, 2026NCT07897578
Show 3 moreShow fewer
- This Study is Comparing Pain Outcomes After Urethral Bulking When Participants Are Randomized to Two Different Pain Medication Regimens.Oct 22, 2026NCT07889687
- Pudendal Nerve Block for Pain Relief During Episiotomy RepairOct 20, 2026NCT07883473
- Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial FibrillationOct 16, 2026NCT07877519
Codes
What other systems call Lidocaine · ClinicalTrials.gg INT007735
- MeSH (NLM) D008012LidocaineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 98PI200987LIDOCAINEConfirmed FDA, NLM, Wikidata
- RxNorm 6387Confirmed FDA, Wikidata
- Wikidata Q216935lidocaineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C614LidocaineOne source FDA
- DrugBank DB00281One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008012 | Lidocaine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 98PI200987 | LIDOCAINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6387 | — | Confirmed FDA, Wikidata |
| Wikidata | Q216935 | lidocaine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C614 | Lidocaine | One source FDA |
| DrugBank | DB00281 | — | One source Wikidata |
Also registered as lidocaine hydrochloride (UNII V13007Z41A · RxNorm 142440).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.