Migraine Disorders clinical trials
The registry lists 1,657 studies for Migraine Disorders across more than 10 countries. 339 are recruiting or about to start. 1,426 of them are mainly about Migraine Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Migraine with Aura: 1,721 studies, 340 open.
ClinicalTrials.gov finds 1,829 studies for Migraine Disorders. How that becomes 1,657 here
This page counts the studies the registry files under Migraine Disorders, and those it files under no condition that list Migraine Disordersthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,829Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −64Filed under a narrower condition, counted on its own pageMigraine without Aura 42 · Migraine with Aura 22
- −79List Migraine Disorders as a condition, but the registry did not file them under itMost often written as “Chronic Migraine, Headache” (26), “Chronic Migraine” (22), and “Vestibular Migraine” (10). The registry filed them under other conditions only, most often Headache (38) and Fibromyalgia (8).
- −29Match it another way26 name it in the title and 3 in a keyword.
- 1,657The count on this page168 of them list Migraine Disorders in their own words; the registry filed them under no condition.
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Status
Who runs them
Danish Headache Center (57) · Pfizer (47) · Eli Lilly and Company (33) · Allergan (29) · GlaxoSmithKline (28) · AbbVie (26) · Theranica (24) · Amgen (24)
What is being tested here
Drugs under test in Migraine Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Rimegepant | 8 | 14 | 26 |
| Topiramate | 7 | 15 | 44 |
| Propranolol | 5 | 4 | 11 |
| Eptinezumab | 4 | 11 | 19 |
| Atogepant | 4 | 8 | 12 |
| Zavegepant | 4 | 6 | 12 |
| Flunarizine | 4 | 0 | 6 |
| Erenumab | 3 | 9 | 35 |
| Bupivacaine | 3 | 2 | 12 |
| Lidocaine | 3 | 1 | 10 |
Drug classes tested here CGRP receptor antagonists 19 open · Local anesthetics 6 open · Beta blockers 5 open · Calcium channel blockers 4 open · Serotonin receptor agonists 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine · Phase 3 · Pfizer
- Dec 2026Efficacy of Gou-Teng-San (GTS) in Patients With Episodic Migraine · Phase 3 · Tsai, Chueh-Yi, MD
- Feb 2027A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · TriGemX Bio, Inc.
- Feb 2027Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches · Phase 3 · University Health Network, Toronto
- Feb 2027BOTOX® vs. XEOMIN® for Chronic Migraine · Phase 3 · Naval Medical Center Camp Lejeune
- Mar 2027A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine · Phase 3 · Merz Therapeutics GmbH
- Mar 2027A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine · Phase 3 · Merz Therapeutics GmbH
- Mar 2027A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine · Phase 3 · H. Lundbeck A/S
- May 2027Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17) · Phase 3 · AbbVie
- Jun 2027Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines · Phase 3 · Wake Forest University Health Sciences
Who these studies take
Of the 216 Migraine Disorders studies recruiting now, 65 (30%) set no upper age limit and 136 (63%) stop at 75 or younger. 44 (20%) take children under 18. 18 (8%) are for women only and 0 (0%) for men only; 36 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 31 (14%) | 30 (14%) |
| 18 | 182 (84%) | 165 (76%) |
| 30 | 189 (88%) | 171 (79%) |
| 40 | 189 (88%) | 171 (79%) |
| 50 | 180 (83%) | 170 (79%) |
| 65 | 155 (72%) | 148 (69%) |
| 75 | 93 (43%) | 87 (40%) |
| 85 | 72 (33%) | 66 (31%) |
Across all 1,657 studies, recruiting or not: 67% stop at 75 or younger and 57% at 65; 15% take children; 7% are for women only and <1% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Migraine Disorders studies take
Of 140 phase 3 interventional studies under Migraine Disorders, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 6 mo2–19 · 53 studies | 4 mo2–12 · 39 studies | — |
| Phase 2 | 15 mo11–30 · 73 studies | 12 mo7–20 · 43 studies | — |
| Phase 2/3 | 18 mo10–23 · 12 studies | — | — |
| Phase 3 | 19 mo12–40 · 140 studies | 18 mo11–31 · 114 studies | — |
| Phase 4 | 27 mo17–37 · 77 studies | 27 mo17–33 · 28 studies | 29 mo18–51 · 49 studies |
| Interventional, no phase | 15 mo7–34 · 358 studies | 11 mo7–22 · 49 studies | 17 mo8–36 · 309 studies |
| Observational | 27 mo13–63 · 160 studies | — | 27 mo13–72 · 132 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting8
- Marine Lipids Ease Painful TMDNov 5, 2026NCT07437313
- Headache Education and Awareness vs. Daily Mindfulness Strategies - Understanding PainNov 5, 2026NCT07513662
- Dietary Intervention for Migraine ReliefOct 30, 2026NCT07360405
- Eary Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT)Oct 29, 2026NCT07191145
- A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency DepartmentOct 27, 2026NCT07667621
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- Efficacy and Safety of BR005-036C Tablets for the Acute Treatment of Migraine in AdultsOct 23, 2026NCT07792681
- Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.Oct 15, 2026NCT05780450
- Suppressive Functions of Regulatory T Cells in MigraineOct 14, 2026NCT07067112
Results posted2
- A Study of K-645 in the Treatment of Multiple Migraine AttacksNov 5, 2026NCT07116499
- Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic MigraineOct 28, 2026NCT03832998
Stopped1
- EMBRACE Study: Enduring Migraine Benefit From Responsive Artery Coil EmbolizationWithdrawnOct 27, 2026NCT07313800
Newly registered4
- A Prospective Study of Rimegepant for Short-term Preventive Treatment of Night-shift-related Migraine in Healthcare ProfessionalsNov 5, 2026NCT07918053
- Migraine Menopause StudyNov 4, 2026NCT07916571
- Efficacy of Rimegepant 75 mg for the Acute Treatment of Migraine: a Bayesian Individual Participant Data Meta-analysis Standardized to Defined Target PopulationsOct 30, 2026NCT07906262
- Impact of Optimized White Light on Visual Discomfort, Headache Intensity, and Cognitive Performance Among Those With MigraineOct 27, 2026NCT07898722
Studies
Recruiting first, then most recently updated. Showing 50 of 1,657. Browse all 1,657 → or search them.
- Biological Profiles of Neuropeptides, Neurotrophins and miRNA in MigraineEnrolling by invitationNCT078320321 country
- Visual Instillation of Sphenopalatine-block Intervention for ONgoing MigraineNot yet recruitingNCT07764783Phase 21 country
- Study of the Glymphatic System in MigraineRecruitingNCT059076551 country
- Marine Lipids Ease Painful TMDRecruitingNCT07437313Not applicable1 country
- A Prospective Study of Rimegepant for Short-term Preventive Treatment of Night-shift-related Migraine in Healthcare ProfessionalsNot yet recruitingNCT07918053Not applicable1 country
- Headache Education and Awareness vs. Daily Mindfulness Strategies - Understanding PainRecruitingNCT07513662Not applicable1 country
- App-based Breathing Program for Migraine ReliefEnrolling by invitationNCT07297901Not applicable1 country
- Migraine Menopause StudyNot yet recruitingNCT07916571Phase 4
- Study of EVO756 in Adults With MigraineRecruitingNCT07616128Phase 24 countries
- A Study to Assess the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of MigraineRecruitingNCT07816367Phase 31 country
- A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of MigraineRecruitingNCT07645924Phase 31 country
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of MigraineRecruitingNCT07674654Phase 31 country
- Dietary Intervention for Migraine ReliefRecruitingNCT07360405Not applicable1 country
- Eary Infusion of Eptinezumab for TreatmEnt of ACute Post-Traumatic Headaches (ELITE-ACT)RecruitingNCT07191145Phase 31 country
- Observational Study to Assess Maternal, Fetal and Infant Outcomes Following Exposure to RimegepantRecruitingNCT050466131 country
- Studio TIARA: Alessitimia ed Emicrania CronicaEnrolling by invitationNCT068910531 country
- Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of MigraineRecruitingNCT04743141Phase 33 countries
- A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency DepartmentRecruitingNCT07667621Phase 11 country
- Basic Body Awareness Therapy in Individuals With MigraineRecruitingNCT07328685Not applicable1 country
- Randomized Study in Children and Adolescents With Migraine: Acute TreatmentRecruitingNCT04649242Phase 39 countries
- Laser Acupuncture for Chronic Migraine: Clinical Response, Traditional Chinese Medicine Syndrome Patterns, and Brain FunctionNot yet recruitingNCT07891585Not applicable1 country
- Efficacy and Safety of BR005-036C Tablets for the Acute Treatment of Migraine in AdultsRecruitingNCT07792681Phase 2/31 country
- Virtual Reality and Biofeedback for Adolescents With Chronic DizzinessRecruitingNCT07374640Early Phase 11 country
- Validation of the Vestibular Migraine Patient Assessment Tool and Handicap Inventory (VM-PATHI) for AdolescentsNot yet recruitingNCT075321091 country
- (Italian Migraine Registry, I-GRAINE-NEW)RecruitingNCT071634161 country
- Overlapping Pain Trajectory StudyRecruitingNCT057523961 country
- Migraine Medication Effects on Urinary SymptomsEnrolling by invitationNCT062126611 country
- Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison StudyRecruitingNCT06972056Phase 41 country
- Psychological Support for Chronic Migraine Patients Treated With Anti-CGRP (Anti-Calcitonin Gene-Related Peptide ) Monoclonal AntibodiesNot yet recruitingNCT078774931 country
- A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic MigraineRecruitingNCT04965675Phase 311 countries
- A Study to Find Out if the Medicine Called Rimegepant is Safe for Adults in IndiaRecruitingNCT07685769Phase 41 country
- Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.RecruitingNCT05780450Not applicable1 country
- A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With MigraineRecruitingNCT07609914Phase 42 countries
- A Study to Learn About the Study Medicine Called Rimegepant in Adults When Used for the Prevention of Chronic MigraineRecruitingNCT07729462Phase 32 countries
- A Study of Eptinezumab in Pediatric Participants With Episodic MigraineRecruitingNCT05897320Phase 311 countries
- Suppressive Functions of Regulatory T Cells in MigraineRecruitingNCT07067112Not applicable1 country
- A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic MigraineRecruitingNCT05164172Phase 311 countries
- Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric SubjectsRecruitingNCT05156398Phase 37 countries
- Acute Treatment of Vestibular Migraine by RimegepantRecruitingNCT07871097Phase 41 country
- Mechanism-Based Cervical Rehabilitation for Chronic MigraineEnrolling by invitationNCT07762690Not applicable1 country
- A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 YearsRecruitingNCT06810505Phase 311 countries
- Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult PatientsRecruitingNCT07646613Phase 21 country
- Validity and Reliability of the Greek WPAI:MigraineNot yet recruitingNCT078475541 country
- Assessment of Head Awareness in Patients With Migraine in the Greek PopulationNot yet recruitingNCT078437451 country
- Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Knee Osteoarthritis(OA)RecruitingNCT07347028Not applicable1 country
- Migraine Headaches Elimination With Patent Foramen Ovale-Directed TherapyRecruitingNCT07629635Phase 31 country
- Greater Occipital Nerve Block for Migraine With Medication Overuse HeadacheRecruitingNCT07568496Not applicable1 country
- RELAXaHEAD for Headache Patients (Phase III)RecruitingNCT06077838Not applicable1 country
- Validity and Reliability of the Greek Pain Catastrophizing ScaleNot yet recruitingNCT078475281 country
- Efficacy of Cognitive Behavioral Therapy at Vestibular MigraineNot yet recruitingNCT07849283Not applicable1 country