Drug
Epinephrine clinical trials
Also written Adrenaline, EpiPen and Primatene Mist.
- studies test it
- 217
- open now
- 35
- in phase 3
- 30
- first study started
- 2000
Keep track of what changes. Save the Epinephrine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Other names
Studies by the year they started
215 studies that test it; most in 2024 (17)
| Year | Studies |
|---|---|
| 2000 | 1 |
| 2002 | 1 |
| 2003 | 3 |
| 2004 | 2 |
| 2005 | 3 |
| 2006 | 3 |
| 2007 | 2 |
| 2008 | 7 |
| 2009 | 1 |
| 2010 | 10 |
| 2011 | 5 |
| 2012 | 10 |
| 2013 | 9 |
| 2014 | 14 |
| 2015 | 13 |
| 2016 | 14 |
| 2017 | 13 |
| 2018 | 12 |
| 2019 | 10 |
| 2020 | 8 |
| 2021 | 8 |
| 2022 | 10 |
| 2023 | 14 |
| 2024 | 17 |
| 2025 | 13 |
| 2026 | 12 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 4
- Phase 1
- 14
- Phase 2
- 32
- Phase 3
- 30
- Phase 4
- 78
- No phase
- 70
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 14 · Other 203
University of Aarhus (5) · Seoul National University Hospital (5) · Cairo University (4) · Nasus Pharma (4) · ARS Pharmaceuticals, Inc. (3) · Amphastar Pharmaceuticals, Inc. (3) · Assiut University (3) · University of Utah (2)
Often tested with
Tested in the same studies.
Ropivacaine (29) · Lidocaine (29) · Bupivacaine (28) · Ketorolac (11) · Dexamethasone (9) · Tranexamic Acid (8) · Phenylephrine (8) · Morphine (7)
Studies
Open first, then newest update. How each study uses Epinephrine is read from its arms, and is right about nine times in ten.
Testing it · 217
- ESP Blocks in Breast Free FlapsRecruitingPhase 1Carilion ClinicNCT07891039Written as Bupivacaine with Epinephrine and Dexamethasone
- Comparison of Milrinone and Epinephrine on TAPSERecruitingNot applicableMansoura UniversityNCT07144267Written as Epinephrine
- Epinephrine Dose: Optimal Versus Standard Evaluation TrialRecruitingPhase 4Unity Health TorontoNCT03826524Written as Epinephrine
- An Outpatient Study of the Efficacy of ARS-2 in Patients With Chronic Spontaneous UrticariaRecruitingPhase 2ARS Pharmaceuticals, Inc.NCT06927999Written as 0.5 mg epinephrine
- Intralesional Chemotherapy (IC): Cisplatin + EpinephrineRecruitingPhase 2University of MiamiNCT07392580Written as Epinephrine injection
- Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral ChallengesRecruitingPhase 1Dr. George LuciukNCT07038746Written as Inhaled Epinephrine
- Intra-Prostatic Epinephrine Injection in Bipolar Transurethral Resection of Large Prostate: Exploring Its Role in Optimizing Surgical OutcomesRecruitingPhase 3Benha UniversityNCT07733167Written as Epinephrine
- Split Face Study of the Duration of Local Anesthetics - Fifth ArmNot yet recruitingPhase 4Weill Medical College of Cornell UniversityNCT07724418Written as Lidocaine HCl/Epinephrine
- Vasopressor Agents in Pulmonary Hypertension CrisisNot yet recruitingNot applicableChina National Center for Cardiovascular DiseasesNCT07667829Written as Epinephrine
- REctus Sheath TrialNot yet recruitingPhase 2Duke UniversityNCT07068243Written as 1.0% lidocaine with epinephrine (1:100,000)
- Effect of Push-Dose Adrenaline on Peri-intubation Hypotension During Rapid Sequence Intubation in the Emergency DepartmentNot yet recruitingPhase 4Marmara University Pendik Training and Research HospitalNCT07620327Written as Adrenaline
- Buffered Versus Conventional Local Anesthesia for Pain and Anxiety Reduction in School-Aged Children With PulpitisRecruitingNot applicableUniversidad Autonoma de San Luis PotosíNCT07638254Written as Buffered Lidocaine with Epinephrine
- Pre-emptive Local Anesthesia and Emergence Behavior After Pediatric Dental General AnesthesiaNot yet recruitingNot applicableseher orbay yasliNCT07604337Written as Articaine Hydrochloride With Epinephrine
- Regional Lipolysis and Adipocyte Lipolysis Protein StimulationRecruitingEarly Phase 1Mayo ClinicNCT06416969Written as Epinephrine
- Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen ImmunotherapyRecruitingPhase 4ARS Pharmaceuticals, Inc.NCT06834165Written as Neffy
- Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological OutcomeNot yet recruitingPhase 3Central Hospital, Nancy, FranceNCT07442071Written as Epinephrine 0.5 mg intravenous bolus
- Local Anesthesia for Facial FracturesRecruitingPhase 2Washington University School of MedicineNCT06429501Written as Bupivacaine/Epinephrine
- Dilute Epinephrine vs Tourniquet for Visualization in Ankle Arthroscopy: A RCTNot yet recruitingNot applicableSecond Affiliated Hospital, School of Medicine, Zhejiang UniversityNCT07349407Written as Epinephrine group
- Vasoactive Drugs in Intensive Care UnitRecruitingPhase 4University of ChicagoNCT02118467Written as Epinephrine
- Adrenaline V/s Dopamine in Fuid Refractory Septic ShockRecruitingNot applicableLaiba QamarNCT07273526Written as Adrenaline
See all 217 studies that test Epinephrine →
Given in every arm · 52 — Epinephrine is usual care beside what is tested
- A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010)RecruitingPhase 2Merck Sharp & Dohme LLCNCT07785609Written as Epinephrine
- A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002)Not yet recruitingPhase 2Merck Sharp & Dohme LLCNCT07793942Written as Epinephrine
- Pre-emptive Local Anesthesia and Sevoflurane Consumption in Pediatric Dental AnesthesiaNot yet recruitingNot applicableTC Erciyes UniversityNCT07608900Written as Articaine With Epinephrine
- Steroid Use in Treatment of Allergic Reactions to FoodRecruitingPhase 4Johannes TrueckNCT07341776Written as Adrenaline (rescue medication)
- Comparison of Bupivacaine Wound Infiltration Versus Wound Instillation to Minimize Postoperative Pain After Thyroid SurgeryNot yet recruitingPhase 3Assiut UniversityNCT06789575Written as Adrenaline
- Liposomal Bupivacaine Use in Alveolar Bone Graft PatientsRecruitingPhase 3Kerry O'RourkeNCT06284434Written as Epinephrine
- Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell LeukemiaActive, not recruitingPhase 2National Cancer Institute (NCI)NCT01059786Written as Epinephrine
- Opioid-Free Pain Protocol After Shoulder ArthroplastyActive, not recruitingPhase 4Henry Ford Health SystemNCT05488847Written as Epinephrine
- Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell TransplantationCompletedPhase 1/2National Cancer Institute (NCI)NCT02356159Written as Epinephrine
- Combination of Buffered Anesthetic to Treat Mandibular MolarsTerminatedPhase 4Indiana UniversityNCT06047366Written as Lidocaine w/ epi
- M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung CancersCompletedPhase 1/2National Cancer Institute (NCI)NCT03554473Written as Epinephrine
- Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)CompletedPhase 4Hospital for Special Surgery, New YorkNCT03094663Written as Bupivacaine with epinephrine
- Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic SurgeryTerminatedEarly Phase 1Riley McLeanNCT04630886Written as Lidocaine Epinephrine
- Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated CoagulationTerminatedPhase 4NYU Langone HealthNCT04814433Written as Lidocaine Hydrochloride with Epinephrine
- Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible PulpitisCompletedPhase 4Indiana UniversityNCT05227300Written as 2% lidocaine with 1:100,000 epinephrine
- Erector Spinae Plane Block Versus Intercostal for VATSCompletedNot applicableMcGill University Health Centre/Research Institute of the McGill University Health CentreNCT03902782Written as Bupivacaine-epinephrine
- Metabolic Adaptation to High-frequent Hypoglycaemia in Type 1 DiabetesStatus unknownNot applicableNordsjaellands HospitalNCT05095259Written as Epinephrin
- The Effect of Buccal Infiltration Administration of Clonidine on the Success Rate of Inferior Alveolar Nerve BlockWithdrawnPhase 4University of California, San FranciscoNCT04186299Written as Articaine Hydrochloride + Epinephrine
- Epinephrine and Cortisol in DepressionWithdrawnEarly Phase 1Stanford UniversityNCT04148261Written as Epinephrine Sulfate (EPI)
- The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper GI BleedingStatus unknownNot applicableDr Cipto Mangunkusumo General HospitalNCT04979273Written as Adrenaline 1 Mg/mL Solution for Injection
Showing 20 of 52.
As the comparator · 35 — what is tested is compared with Epinephrine
- R.E.C.K vs Exparel in Robotic NephrectomyRecruitingPhase 3Wake Forest University Health SciencesNCT07092566Written as Epinephrine
- Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With EpinephrineRecruitingNot applicableBoston Children's HospitalNCT06471348Written as Bupivacaine Hydrochloride and Epinephrine Injection
- Risk of Nerve Damage After Administration of Local AnesthesiaRecruitingPhase 1Cleveland Dental InstituteNCT06564987Written as 2% lidocaine with 1:100,000 epinephrine
- Exparel Injection Effect on Postoperative Opioid UsageEnrolling by invitationEarly Phase 1University of Missouri-ColumbiaNCT04085913Written as Lidocaine Epinephrine
- Control of Iatrogenic Endobronchial Bleeding by Tranexamic Acid, Adrenalin and HemagglutinaseRecruitingEarly Phase 1China-Japan Friendship HospitalNCT06149091Written as Adrenalin
- Tranexamic Acid During Upper GI Endoscopic Resection ProceduresRecruitingPhase 4Assaf-Harofeh Medical CenterNCT05688020Written as Epinephrine injection
- Adding Dexamethasone to Lidocaine in Scalp Incision Infiltration for CraniotomyCompletedNot applicableAssiut UniversityNCT07788261Written as Xylocaine plus epinephrine
- The Use of Lidocaine Gel Versus Subconjunctival Xylocaine Injection in Pterygium ExcisionCompletedPhase 4Vrije Universiteit BrusselNCT05978687Written as Xylocaine with Epinephrine
- The Efficacy of Tranexamic Acid and Adrenaline to Control Endobronchial BleedingCompletedNot applicableSheikh Zayed Federal Postgraduate Medical InstituteNCT07759089Written as Adrenaline
- Comparison Between Levosimendan and Adrenaline in CABG PatientsCompletedNot applicableAssiut UniversityNCT05222256Written as Adrenaline
- PK/PD Study of IN-001 Sublingual Spray in Healthy AdultsCompletedPhase 1Insignis Therapeutics, Inc.NCT07210320Written as Epinephrine Auto-Injector 0.3 mg/0.3 mL
- Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary ResuscitationActive, not recruitingPhase 1University of AlbertaNCT05738148Written as Epinephrine
- Effects of Local Ketamine in Orthognathic ProceduresActive, not recruitingNot applicableBezmialem Vakif UniversityNCT07066306Written as Articaine Hydrochloride + Epinephrine
- Multimodal Orthognathic Study Comparing Use of Exparel With Standard of Care.CompletedEarly Phase 1United States Naval Medical Center, San DiegoNCT06499181Written as Epinephrin
- The Effects of Combined Spinal Epidurals on Fever During Labor of First-Time MothersWithdrawnNot applicableOchsner Health SystemNCT00802646Written as fentanyl/bupivacaine/epinephrine
- US-Guided Serratus Anterior Plane Block Versus Thoracic Epidural in Patients Undergoing ThoracotomyCompletedNot applicableNational Cancer Institute, EgyptNCT05672394Written as lidocaine with epinephrine
- Over-the-scope Clips and Standard Treatments in Endoscopic Control of Acute Bleeding From Non-variceal Upper GI CausesCompletedNot applicableChinese University of Hong KongNCT03216395Written as Epinephrine
- Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.CompletedPhase 4Ohio State UniversityNCT01862614Written as Articaine Hydrochloride + Epinephrine
- Liposomal Bupivacaine in Implant Based Breast ReconstructionTerminatedNot applicableLoma Linda UniversityNCT02659501Written as Bupivacaine with epinephrine
- Trigger Finger Corticosteroid Injection With and Without Local AnestheticCompletedPhase 4Vanderbilt University Medical CenterNCT04023695Written as Corticosteroid with lidocaine with epinephrine
Showing 20 of 35.
Codes
What other systems call Epinephrine · ClinicalTrials.gg INT007427
- MeSH (NLM) D004837EpinephrineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) YKH834O4BHEPINEPHRINEConfirmed FDA, NLM, Wikidata
- RxNorm 3992Confirmed FDA, Wikidata
- Wikidata Q132621epinephrineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C473Therapeutic EpinephrineOne source FDA
- DrugBank DB00668One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D004837 | Epinephrine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | YKH834O4BH | EPINEPHRINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 3992 | — | Confirmed FDA, Wikidata |
| Wikidata | Q132621 | epinephrine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C473 | Therapeutic Epinephrine | One source FDA |
| DrugBank | DB00668 | — | One source Wikidata |
Also registered as epinephrine acetate (UNII M1NJX34RVJ), epinephrine bitartrate (UNII 30Q7KI53AK · RxNorm 203180) and epinephrine hydrochloride (UNII WBB047OO38 · RxNorm 362).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.