Drug
Ketamine clinical trials
Also written Ketalar and Calypsol.
Includes 235 studies of Esketamine.
- studies test it
- 1,116
- open now
- 207
- in phase 3
- 174
- first study started
- 2001
Keep track of what changes. Save the Ketamine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
1,110 studies that test it; most in 2022 (91); 5 more planned to start later
| Year | Studies |
|---|---|
| 2001 | 3 |
| 2002 | 2 |
| 2003 | 3 |
| 2004 | 9 |
| 2005 | 6 |
| 2006 | 8 |
| 2007 | 14 |
| 2008 | 17 |
| 2009 | 19 |
| 2010 | 22 |
| 2011 | 30 |
| 2012 | 36 |
| 2013 | 45 |
| 2014 | 54 |
| 2015 | 68 |
| 2016 | 63 |
| 2017 | 64 |
| 2018 | 51 |
| 2019 | 60 |
| 2020 | 60 |
| 2021 | 79 |
| 2022 | 91 |
| 2023 | 76 |
| 2024 | 83 |
| 2025 | 76 |
| 2026 | 71 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 56
- Phase 1
- 138
- Phase 2
- 237
- Phase 3
- 174
- Phase 4
- 336
- No phase
- 265
What it is tested for
Each study’s main condition, where its own words name it.
- Depression
- 108
Who runs them
Industry 70 · Other 1,046
Janssen Research & Development, LLC (36) · Assiut University (33) · Yale University (24) · Peking University First Hospital (22) · Ain Shams University (19) · Beijing Tiantan Hospital (17) · New York State Psychiatric Institute (14) · Mayo Clinic (13)
Often tested with
Tested in the same studies.
Dexmedetomidine (108) · Propofol (47) · Lidocaine (43) · Midazolam (40) · Fentanyl (20) · Magnesium Sulfate (18) · Sevoflurane (14) · Remifentanil (13)
Studies
Open first, then newest update. How each study uses Ketamine is read from its arms, and is right about nine times in ten.
Testing it · 1,116
- Intravenous Ketamine for Acute Suicidal Crisis and Psychiatric Hospital Length of StayNot yet recruitingPhase 2University of Sao PauloNCT07888933Written as Esketamine
- Ketamine Sedation in the ICU (KANINE) RCTRecruitingPhase 3McMaster UniversityNCT06767358Written as ketamine hydrochloride
- Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderRecruitingPhase 1National Institute of Mental Health (NIMH)NCT03065335Written as Ketamine
- Morphine or Ketamine for AnalgesiaRecruitingPhase 3Columbia UniversityNCT06835504Written as Ketamine hydrochloride
- Ketamine for Opioid Use DisorderRecruitingPhase 2University of Maryland, BaltimoreNCT06943859Written as Treatment with Ketamine
- Intranasal Dexmedetomidine Combined With Esketamine for Emergence Quality After Suspension LaryngoscopyNot yet recruitingNot applicableThe First Hospital of Jilin UniversityNCT07880938Written as Esketamine
- Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial.Not yet recruitingPhase 4Region SkaneNCT07881562Written as Esketamine
- Intravenous Ketamine for Treatment-Resistant DepressionRecruitingPhase 2Mayo ClinicNCT06668571Written as Ketamine
- Neurobiology of SuicideRecruitingPhase 2National Institute of Mental Health (NIMH)NCT02543983Written as Ketamine Hydrochloride
- Alleviating Suicidality by Combining Psychotherapy and IM Ketamine for Rapid Treatment in the Emergency DepartmentRecruitingPhase 2The University of Texas Health Science Center at San AntonioNCT07868913Written as Ketamine Injectable Solution
- Ketamine Effects on Learning In Eating DisordersEnrolling by invitationPhase 2Amanda Downey, MDNCT06736769Written as Ketamine infusion
- Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After SurgeryNot yet recruitingPhase 4Peking University First HospitalNCT07576517Written as Dex-Esk
- Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After SurgeryNot yet recruitingPhase 4Peking University First HospitalNCT07576543Written as Dex-Esk
- Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus SurgeryNot yet recruitingPhase 4Assiut UniversityNCT07871292Written as Ketamine and Propofol
- Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of KetamineRecruitingEarly Phase 1University of PennsylvaniaNCT06788249Written as Ketamine only
- Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean SectionNot yet recruitingPhase 4Assiut UniversityNCT07855523Written as Midazolam and Ketamine
- Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous NephrolithotomyNot yet recruitingPhase 4Assiut UniversityNCT07855068Written as Ketamine and Dexmedetomidine
- Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean DeliveryRecruitingPhase 1University of UtahNCT06767566Written as Ketamine (Ketalar)
- A Study Comparing Oral Ketamine With Oral Midazolam for the Treatment of Major Depressive EpisodesNot yet recruitingPhase 3Jawaharlal Institute of Postgraduate Medical Education & ResearchNCT07839338Written as Oral ketamine
- Ketamine & Crisis Response Plan for Suicidal Ideation in the EDRecruitingPhase 2/3The University of Texas Health Science Center at San AntonioNCT05696691Written as Ketamine Hydrochloride
See all 1,116 studies that test Ketamine →
Given in every arm · 50 — Ketamine is usual care beside what is tested
- InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpressionRecruitingPhase 3Sunnybrook Health Sciences CentreNCT06781697Written as Ketamine
- Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department.Not yet recruitingPhase 4Sultan Qaboos UniversityNCT07874919Written as Ketamine (1 mg/kg)
- Behavioural Activation Therapy and Ketamine for Treatment-Resistant DepressionNot yet recruitingPhase 2/3The Royal's Institute of Mental Health ResearchNCT07801703Written as Ketamine (0.5 mg/kg)
- Glutamatergic Mechanisms: Aim2RecruitingPhase 1New York State Psychiatric InstituteNCT05401227Written as Ketamine
- The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal EffectsRecruitingPhase 2Yale UniversityNCT05786066Written as Ketamine
- Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine ResponseRecruitingPhase 1Yale UniversityNCT05915013Written as Ketamine
- Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery EnhancementNot yet recruitingPhase 2University of California, San DiegoNCT07369089Written as Ketamine
- Esketamine With or Without Integration Therapy for Treatment-Resistant DepressionRecruitingPhase 4University of Puerto RicoNCT07369102Written as Esketamine hydrochloride (intranasal)
- Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid DepressionRecruitingPhase 2VA Office of Research and DevelopmentNCT06419439Written as Ketamine hydrochloride
- Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of DepressionRecruitingPhase 2Icahn School of Medicine at Mount SinaiNCT06559826Written as Ketamine
- ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant DepressionRecruitingPhase 4University of SaskatchewanNCT03272698Written as Ketamine
- Ketamine for Multiple Sclerosis FatigueActive, not recruitingPhase 2Johns Hopkins UniversityNCT05378100Written as Ketamine
- Comparison of High Flow vs Standard Nasal Cannula in Children With Burns Under SedoanalgesiaCompletedNot applicableZeliha AlicikusNCT06663293Written as midazolam, ketamine, propofol
- Behavioural Activation Therapy and Esketamine for Resistant DepressionTerminatedNot applicableThe Royal's Institute of Mental Health ResearchNCT06431386Written as Esketamine
- Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Healthy Han Chinese, Korean, Japanese, and Caucasian Participants and the Effects of Rifampin on the Pharmacokinetics of Intranasally Administered EsketamineCompletedPhase 1Janssen Research & Development, LLCNCT02846519Written as Esketamine
- A Study to Investigate the Different Modes of (S) Ketamine Administration in Healthy ParticipantsCompletedPhase 1Janssen Research & Development, LLCNCT03808259Written as (S)-ketamine Oral Thin Film
- A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive DisorderCompletedPhase 1Janssen Research & Development, LLCNCT02919579Written as Esketamine
- Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver AblationCompletedNot applicablePeking University First HospitalNCT06003218Written as Dexmedetomidine-esketamine combination
- Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot TrialCompletedPhase 1Yale UniversityNCT03367533Written as Ketamine
- Pharmacokinetic Study of Intranasal Esketamine and Its Effects on the Pharmacokinetics of Orally-Administered Midazolam and Bupropion in Healthy ParticipantsCompletedPhase 1Janssen Research & Development, LLCNCT02568176Written as Esketamine
Showing 20 of 50.
As the comparator · 43 — what is tested is compared with Ketamine
- (2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic PainRecruitingPhase 1/2Rush University Medical CenterNCT05864053Written as Ketamine
- Analgosedation With Ketamine, Nalbuphine, or Dexmedetomidine for Suture Removal in Children After Cleft SurgeryRecruitingNot applicableUniversity Medical Centre LjubljanaNCT07340008Written as ketamine
- Ayahuasca, Esketamine and PTSDRecruitingPhase 2University of Sao PauloNCT07317206Written as Esketamine
- Ayahuasca, Esketamine and Body Image PerceptionRecruitingNot applicableUniversity of Sao PauloNCT07317219Written as Esketamine
- Ayahuasca, Esketamine and Premenstrual SymptomsRecruitingNot applicableUniversity of Sao PauloNCT07317232Written as Esketamine
- Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator TrialRecruitingPhase 2University of IowaNCT06405607Written as Ketamine
- Pragmatic Trial of Psilocybin Therapy in Palliative CareRecruitingPhase 2Charles S. Grob, M.D.NCT05403086Written as Ketamine
- Comparison of Intravenous Lidocaine vs Ketamine in Colorectal SurgeryRecruitingNot applicableUniversity Tunis El ManarNCT06272461Written as Ketamine Injectable Solution
- Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve GastrectomyNot yet recruitingNot applicableIVO JURISICNCT07084753Written as ketamine
- Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative SedationRecruitingNot applicableMaternal and Child Health Hospital of Hubei ProvinceNCT07050212Written as esketamine group
- Intranasal Dexmedetomidine Plus Ketamine for Procedural SedationRecruitingPhase 2/3Naveen PoonaiNCT04195256Written as IV Ketamine
- Psilocybin Versus Ketamine in Treatment-Resistant DepressionRecruitingPhase 2National Institute of Mental Health, Czech RepublicNCT05383313Written as Ketamine Hydrochloride
- Comparison of Intravenous Ondansetron and Low Dose Ketamine in Preventing Post Spinal ShiveringCompletedNot applicableMayo Hospital LahoreNCT07334223Written as Ketamine (0.25 mg/kg)
- Dexmedetomidine Versus Ketamine Loading for Dexmedetomidine Sedation During Elective Cesarean Section Under Spinal AnesthesiaCompletedPhase 4Haseki Training and Research HospitalNCT07676955Written as Ketamine
- Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive DisorderCompletedNot applicableTanta UniversityNCT07526454Written as Ketamine
- Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot TrialCompletedPhase 4Unity Health TorontoNCT05639322Written as Ketamine Hydrochloride
- IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm FracturesWithdrawnEarly Phase 1Phoenix Children's HospitalNCT03466242Written as Ketamine
- Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use DisorderActive, not recruitingPhase 2Peggy C NopoulosNCT05421065Written as Ketamine
- Comparison of Prophylactic Use of Tramadol Versus Ketamine for Prevention of Post Spinal Anesthesia ShiveringCompletedPhase 3Syed Muhammad AbbasNCT07043049Written as Ketamine
- Ketamine Versus Neostigmine in Ultrasound-Guided Transversus Abdominis Plane Block in Caesarean SectionCompletedPhase 3Alexandria UniversityNCT06871033Written as TAP block with Ketamine
Showing 20 of 43.
Codes
What other systems call Ketamine · ClinicalTrials.gg INT007707
- MeSH (NLM) D007649KetamineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 690G0D6V8HKETAMINEConfirmed FDA, NLM, Wikidata
- RxNorm 6130Confirmed FDA, Wikidata
- Wikidata Q243547(RS)-ketamineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61797KetamineOne source FDA
- DrugBank DB01221One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D007649 | Ketamine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 690G0D6V8H | KETAMINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6130 | — | Confirmed FDA, Wikidata |
| Wikidata | Q243547 | (RS)-ketamine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61797 | Ketamine | One source FDA |
| DrugBank | DB01221 | — | One source Wikidata |
Also registered as ketamine hydrochloride (UNII O18YUO0I83 · RxNorm 203184).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.