An interventional study of Group D (dexmedetomidine group) and Group L (Lidocaine group) in Sore Throat, Dexmedetomidine Analgesia and Tonsillectomy, sponsored by Fayoum University Hospital. Recruiting at 1 site in Egypt. Open to female participants aged 3 Years to 15 Years. Per ClinicalTrials.gov, last updated 2026-08-21.
Sponsored by Fayoum University Hospital · Not applicable, Interventional, and Treatment
The aim of the study is to compare the effect of nebulized Dexmedetomidine compared to nebulized Lidocaine on postoperative sore throat in childern undergoing Tonsillectomy.
Tonsillectomy is one of the most commonly performed day-case surgeries in pediatric patients. Despite its routine nature, post operative sore throat (POST) remains significant cause of morbidity, leading to discomfort and reduced parental satisfaction(1) POST ranked sixth among the 10 most undesirable adverse effects related to general anesthesia (2). Irritation and inflammation of the airway caused by pressure exerted on the tracheal wall by the endotracheal tube (ETT)(3) trauma during intubation and mucosal dehydration(4) are thought to be the mechanistic basis for a postoperative sore throat (POST) During tonsillectomy, the shared surgical and anesthetic field poses a risk of airway manipulation, necessitating close cooperation between surgeon and anesthesiologist to maintain adequate oxygenation and a clear operative field(5) Intraoperative blood or fluid aspiration can further exacerbate upper airway irritation, contributing to POST(6) Given the impact of POST on patient well-being, effective preventive strategies are essential for optimizing postoperative recovery (7) Nebulization therapy is widely used to prevent POST. It is highly recommended because of small volume of drugs required for effect, easy way of administration, better patient compliance, and most importantly little risk of adverse events compared with other methods(such as gargle, intravenous, etc.)(8) Commonly used aerosolized drugs include corticosteroids, ketamine, magnesium, lidocaine, Non-steroidal anti-inflammatory drugs(NSAIDs), etc. and have achieved various effects(9_12) Previous studies showed promising results for both Nebulized Dexmedetomidine and Nebulized Lidocaine in Attenuating Sore Throat(13_14) , yet no study has directly compared the efficacy of Nebulized Dexmedetomidine Versus Nebulized Lidocaine in Attenuating Sore Throat Following Tonsillectomy.
226 studies on the registry are indexed under Pharyngitis; 35 are open to participants now.
This study's planned enrollment of 70 is below the median of 144 across 188 interventional studies indexed under Pharyngitis.
Browse Pharyngitis studies →Fayoum University Hospital is the lead sponsor of 77 studies on the registry; 14 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
will recieve a dose of Dexmedetomidine 1 mcg/kg
Drug: Group D (dexmedetomidine group)
will recieve Lidocaine 2%, 1 mg/kg
Drug: Group L (Lidocaine group)
group D (Dexmedetomidine group) will recieve a dose of 1 mcg/kg
will recieve Lidocaine 2%, 1 mg/kg
Incidence of Postoperative Sore Throat (POST)
Time frame: immediately on PACU
Severity of sore throat (ST)
specifically at the 4th postoperative hour. ST was scored on a four-point scale (0-3) (20) 0 =No ST 1. =mild ST (complains of ST only on asking); 2. =moderate ST (complains of ST on his/her own) 3. =severe ST (change in voice or hoarseness, associated with throat pain).
Time frame: at the 4th postoperative hour
*Hemodynamic Parameters
Heart Rate
Time frame: every 5 minutes intraoperatively and at 0,1,3,6,12 and 24hrs postoperatively
Hemodynamic Parameters
Mean Arterial Blood Pressure
Time frame: every 5 minutes intraoperatively and at 0,1,3,6,12 and 24hrs postoperatively
Hemodynamic Parameters
Oxygen Saturation ( SPO2 )
Time frame: every 5 minutes intraoperatively and at 0,1,3,6,12 and 24hrs postoperatively
evaluation of other adverse effects
such as nausea, vomiting and cough
Time frame: during the first postoperative hour.
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Studies of the drug tested here: Dexmedetomidine
Fayoum University Hospital