Drug
Bupivacaine clinical trials
Also written Marcaine, Exparel, SKY0402 and Marcain.
Includes 296 studies of Liposomal Bupivacaine.
- studies test it
- 1,173
- open now
- 169
- in phase 3
- 157
- first study started
- 2002
Keep track of what changes. Save the Bupivacaine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Other names
- Marcain
- 10
Studies by the year they started
1,168 studies that test it; most in 2024 (95); 1 more planned to start later
| Year | Studies |
|---|---|
| 2002 | 1 |
| 2003 | 2 |
| 2004 | 3 |
| 2005 | 8 |
| 2006 | 8 |
| 2007 | 14 |
| 2008 | 18 |
| 2009 | 22 |
| 2010 | 19 |
| 2011 | 24 |
| 2012 | 33 |
| 2013 | 46 |
| 2014 | 63 |
| 2015 | 81 |
| 2016 | 78 |
| 2017 | 87 |
| 2018 | 86 |
| 2019 | 91 |
| 2020 | 48 |
| 2021 | 80 |
| 2022 | 64 |
| 2023 | 74 |
| 2024 | 95 |
| 2025 | 70 |
| 2026 | 53 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 28
- Phase 1
- 59
- Phase 2
- 142
- Phase 3
- 157
- Phase 4
- 460
- No phase
- 375
What it is tested for
Each study’s main condition, where its own words name it.
- Pain
- 10
Who runs them
Industry 84 · Other 1,089
Pacira Pharmaceuticals, Inc (52) · Assiut University (38) · Ain Shams University (28) · Cairo University (24) · Mayo Clinic (22) · Ataturk University (22) · Istanbul University (17) · Icahn School of Medicine at Mount Sinai (14)
Often tested with
Tested in the same studies.
Dexamethasone (45) · Dexmedetomidine (42) · Ropivacaine (38) · Fentanyl (37) · Lidocaine (37) · Epinephrine (28) · Morphine (27) · Meloxicam (14)
Studies
Open first, then newest update. How each study uses Bupivacaine is read from its arms, and is right about nine times in ten.
Testing it · 1,173
- ESP Blocks in Breast Free FlapsRecruitingPhase 1Carilion ClinicNCT07891039Written as Bupivacaine with Epinephrine and Dexamethasone
- Anterior Iliopsoas Space Block Versus PENG Block on Ease of Positioning for Spinal Anathesia in Patients Undergoing Hip SurgeriesRecruitingPhase 3Benha UniversityNCT07467356Written as Bupivacaine
- Enhanced Recovery After Surgery (ERAS) in Live Donor Kidney Transplant RecipientsEnrolling by invitationPhase 4Baylor Research InstituteNCT06997016Written as Bupivacaine
- Intravesical Bupivacaine on Post-Operative Ureteroscopy PainRecruitingPhase 2University of ChicagoNCT06635889Written as Bupivacaine
- Nephrostomy Tract Infiltration for Pain Control After PCNLRecruitingNot applicableHitit UniversityNCT07721571Written as Bupivacaine
- Two Bupivacaine Concentrations for Rectus Intercostal Fascial Plane Block After Laparoscopic CholecystectomyNot yet recruitingNot applicableMedipol UniversityNCT07841951Written as Bupivacaine 0.25% - rectus intercostal fascial plane block
- Parasternal Intercostal Nerve Block and Chronic Pain After Cardiac SurgeryNot yet recruitingNot applicableBakirkoy Dr. Sadi Konuk Research and Training HospitalNCT07818512Written as Bupivacaine 0.25%
- A Study of Bupivacaine Liposome Injection in Local Analgesia of Pediatric PatientsRecruitingPhase 4Jiangsu HengRui Medicine Co., Ltd.NCT06344091Written as Bupivacaine Liposome Injection
- Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)RecruitingNot applicableSecond Affiliated Hospital of Wenzhou Medical UniversityNCT06452147Written as Bupivacaine liposome
- Mepivacaine Versus Bupivacaine Onset Time in Ultrasound-guided Ankle BlocksEnrolling by invitationPhase 4Mayo ClinicNCT05425979Written as Bupivacaine
- Nerve Block for Severe Abdominal Pain in the Emergency DepartmentRecruitingEarly Phase 1University of California, IrvineNCT07826936Written as Bupivacaine (erector spinae plane block)
- Pain Control for Undergoing Costal Cartilage HarvestingRecruitingPhase 4Mayo ClinicNCT05285566Written as Exparel
- QL Block in Laparoscopic MyomectomyRecruitingPhase 4Joseph Findley MDNCT05979493Written as Bupivacain
- Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody FusionEnrolling by invitationPhase 2/3Foundation for Orthopaedic Research and EducationNCT06350981Written as Exparel
- A Study Of Stellate Ganglion Blockade With Liposomal Bupivacaine In Preventing Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting SurgeryNot yet recruitingPhase 4Mayo ClinicNCT07570940Written as Liposomal bupivacaine
- Nebulized Bupivacaine Analgesia for Cleft Palate RepairRecruitingPhase 3Assiut UniversityNCT04928352Written as Bupivacaine Hydrochloride
- Effect of Local Anesthetic Concentration on Rebound PainRecruitingPhase 4University of VirginiaNCT07146685Written as Bupivacaine
- Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in Orthopedic Surgery.Not yet recruitingPhase 4Shanghai Jiao Tong University Affiliated Sixth People's HospitalNCT07606911Written as liposomal bupivacaine
- Liposomal Bupivacaine vs Ropivacaine for Post-hemorrhoidectomy AnalgesiaNot yet recruitingPhase 4Tongliao City People's HospitalNCT07795203Written as Liposomal Bupivacaine (EXPAREL®)/Bupivacaine
- Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee ArthroplastyNot yet recruitingPhase 4Wake Forest University Health SciencesNCT07097493Written as Liposomal Bupivacaine
See all 1,173 studies that test Bupivacaine →
Given in every arm · 269 — Bupivacaine is usual care beside what is tested
- Modified Thoracolumbar Interfascial Plane Block vs Retrolaminar Block for Pain in Lumbar Spine SurgeriesRecruitingNot applicableZagazig UniversityNCT07883616Written as Bupivacaine
- Exparel and DexamethasoneNot yet recruitingPhase 4Duke UniversityNCT07614802Written as Liposomal Bupivacaine with Bupivacaine
- Low-Volume Pericapsular Nerve Group (PENG) Block With Dexamethasone vs Standard-Volume PENG Block After Total Hip ArthroplastyRecruitingPhase 4Ain Shams UniversityNCT07855341Written as Bupivacaine
- Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery.RecruitingPhase 3Children's Cancer Hospital Egypt 57357NCT07878156Written as Bupivacaine 0.25%
- Dexmedetomidine as an Adjuvant to Greater Auricular Nerve Block in Middle Ear SurgeriesRecruitingPhase 2Minia UniversityNCT07878533Written as Bupivacaine
- Dural Sac Area-Guided Spinal Anesthesia Dosing for TURPEnrolling by invitationNot applicableIstanbul UniversityNCT07794852Written as Bupivacaine
- Safety and Efficacy of Dexamethasone Versus Dexmedetomidine as Adjuvants in PENG Block in Hip Surgeries for Postoperative Pain ManagementNot yet recruitingPhase 3Assiut UniversityNCT07847047Written as Bupivacaine 0.25%
- Effect of Post-Radiofrequency Corticosteroid Injection on the Incidence of Post-Neurotomy NeuritisEnrolling by invitationPhase 2Siriraj HospitalNCT07839195Written as Bupivacaine
- Ultrasound-Guided Ilioinguinal-Iliohypogastric Nerve Block Following Spinal Anesthesia Comparing Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Unilateral Inguinal Hernia RepairNot yet recruitingPhase 4Assiut UniversityNCT07837492Written as Bupivacaine
- Erector Spinae Plane Block Versus Infraspinatus-Teres Minor Interfascial Plane Block for Analgesia After Shoulder ArthroscopyNot yet recruitingNot applicableTaksim Egitim ve Arastirma HastanesiNCT07688395Written as Bupivacaine %0.25 (isobaric)
- Comparing Three Epidural Steroid Injection Approaches for Lumbar Radicular PainNot yet recruitingPhase 4Benha UniversityNCT07813988Written as Bupivacaine
- Magnesium Sulfate With Standard Combined Costoclavicular-Suprascapular Block for Pain Relief After Shoulder Arthroscopy.Not yet recruitingNot applicableAssiut UniversityNCT07798115Written as Bupivacaine
- Analgesic Outcomes of Ultrasound-Guided QLB vs TAP Block in Midline LaparotomyNot yet recruitingNot applicableSheikh Zayed Medical CollegeNCT07796828Written as Bupivacaine 0.25%
- Comparative Study Between Pericapsular Nerve Group Block (PENG) And Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block for Positioning Analgesia Prior to Spinal Anesthesia in Hip Fracture PatientsRecruitingNot applicableAin Shams UniversityNCT07687290Written as bupivacaine 0.25%.
- Interscalene Brachial Plexus Block Versus Serratus Posterior Superior Intercostal Plane Block for Arthroscopic Shoulder SurgeryRecruitingNot applicableFerit YetikNCT07668648Written as Bupivacaine
- Erector Spinae Plane Block and Low-Flow Anaesthesia in Laparoscopic CholecystectomyRecruitingNot applicableTaksim Egitim ve Arastirma HastanesiNCT07653490Written as Bupivacaine
- Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated CoagulationNot yet recruitingPhase 4NYU Langone HealthNCT07644923Written as Bupivacaine
- Comparative Study Between Ultrasound Guided Paravertebral Plane Block and Erector Spinae Plane Block on Post-operative Analgesia After Total Abdominal HysterectomyNot yet recruitingNot applicableAin Shams UniversityNCT07610070Written as bupivicaine 0.25%
- Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery OutcomesNot yet recruitingPhase 2Ganesh M. ShankarNCT07201987Written as Bupivacaine (local, via calcium sulfate beads)
- Caudal Dexmedetomidine vs Ketamine for Postoperative Analgesia in Pediatric DDH SurgeryNot yet recruitingNot applicableAssiut UniversityNCT07385352Written as Bupivacaine
Showing 20 of 269.
As the comparator · 92 — what is tested is compared with Bupivacaine
- Bupivacaine-Lidocaine vs Bupivacaine for Ultrasound-Guided Popliteal Sciatic Nerve BlockRecruitingNot applicableAtaturk UniversityNCT07550348Written as Bupivacaine
- Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis ReleaseRecruitingPhase 4Northwestern UniversityNCT07840183Written as Bupivicaine
- Topical Magnesium Sulfate Versus Peritonsillar Bupivacaine for Post-Tonsillectomy Pain Relief in ChildrenNot yet recruitingPhase 4Assiut UniversityNCT07760207Written as Bupivacaine
- Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKANot yet recruitingPhase 4Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)NCT07430085Written as Bupivacaine
- Bupivacaine Liposomes or Bupivacaine for CMB on Postoperative Analgesia in Laparoscopic Hepatobiliary Pancreatic SurgeryRecruitingPhase 4Huazhong University of Science and TechnologyNCT06737341Written as Bupivacaine(B)
- Sciatic Nerve Block With ALX006 in Subjects Undergoing BunionectomyRecruitingPhase 2Rebel Medicine IncNCT07574385Written as Bupivacaine Hcl 0.25% Inj
- Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal HystrectomyRecruitingPhase 1/2Liaquat National Hospital & Medical CollegeNCT07482709Written as bupivicaine 0.25%
- Post Operative Infusion Pump Pain StudyRecruitingPhase 4Rutgers, The State University of New JerseyNCT07349810Written as Bupivacaine 0.5% Injectable Solution
- Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal AnesthesiaRecruitingNot applicableCairo UniversityNCT07139522Written as Bupivacaine
- Analgesic Effect of Bupivacaine Plus Ketamine Versus Bupivacaine Alone in Transversalis Fascia Plane BlockNot yet recruitingPhase 1Ain Shams UniversityNCT06935669Written as Bupivacaine
- Systemic Versus Local Dexmedetomidine As an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae BlockRecruitingPhase 3Aswan UniversityNCT06386770Written as Bupivacaine Hydrochloride
- Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for MastectomiesRecruitingPhase 4United States Naval Medical Center, PortsmouthNCT06252662Written as Liposomal bupivacaine
- Testing the Feasibility of Using Ropivacaine in Spinal Anesthesia for Patients With Lower Back SurgeryRecruitingEarly Phase 1Fraser HealthNCT05824338Written as Spinal anesthesia for lumbar surgery: bupivacaine
- Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral PalsyRecruitingPhase 4University of California, Los AngelesNCT06189781Written as Bupivacaine, lidocaine, ropivacaine
- Phase 2/3 Study of TLC590 for Postsurgical Pain ManagementNot yet recruitingPhase 2/3Taiwan Liposome CompanyNCT05161637Written as Bupivacain
- Epidural Oxycodone for Pain Management for Lower Limb AmputationRecruitingNot applicableKafrelsheikh UniversityNCT06276179Written as Bupivacaine
- Single Shot Intrathecal Analgesia in Vaginal DeliveryRecruitingNot applicableAin Shams UniversityNCT05998551Written as Bupivacaine Hcl 0.5% Inj
- Phase 2B Study Assessing Pain Relief After Replacement of the KneeCompletedPhase 2Allay Therapeutics, Inc.NCT06799845Written as bupivacaine hydrochloride
- Vaginal Cuff Infiltration With Liposomal Bupivacaine for Pain Relief: A Double Blind, Randomized Controlled TrialWithdrawnPhase 4Jefferson DrapkinNCT05823363Written as Bupivacaine only
- A Study of TLC590 for Postsurgical Pain Following BunionectomyActive, not recruitingPhase 3TLC Biopharmaceuticals, Inc.NCT07222748Written as Liposomal Bupivacaine
Showing 20 of 92.
Codes
What other systems call Bupivacaine · ClinicalTrials.gg INT007098
- MeSH (NLM) D002045BupivacaineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) Y8335394ROBUPIVACAINEConfirmed FDA, NLM, Wikidata
- RxNorm 1815Confirmed FDA, Wikidata
- Wikidata Q422806bupivacaine-(RS)Confirmed FDA, NLM, Wikidata
- NCI Thesaurus C62011BupivacaineOne source FDA
- DrugBank DB00297One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D002045 | Bupivacaine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | Y8335394RO | BUPIVACAINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1815 | — | Confirmed FDA, Wikidata |
| Wikidata | Q422806 | bupivacaine-(RS) | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62011 | Bupivacaine | One source FDA |
| DrugBank | DB00297 | — | One source Wikidata |
Also registered as bupivacaine hydrochloride (UNII 7TQO7W3VT8 · RxNorm 267396) and bupivacaine hydrochloride anhydrous (UNII AKA908P8J1 · RxNorm 1375412).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.