Drug
Diphenhydramine clinical trials
Also written Benadryl.
- studies test it
- 68
- open now
- 12
- in phase 3
- 10
- first study started
- 2000
Keep track of what changes. Save the Diphenhydramine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Brand
- Benadryl
- 18
Studies by the year they started
68 studies that test it; most in 2008 (7)
| Year | Studies |
|---|---|
| 2000 | 1 |
| 2002 | 1 |
| 2004 | 2 |
| 2005 | 1 |
| 2006 | 2 |
| 2007 | 4 |
| 2008 | 7 |
| 2009 | 2 |
| 2010 | 3 |
| 2011 | 2 |
| 2012 | 3 |
| 2013 | 6 |
| 2014 | 2 |
| 2015 | 4 |
| 2016 | 1 |
| 2017 | 4 |
| 2019 | 4 |
| 2020 | 2 |
| 2021 | 2 |
| 2022 | 2 |
| 2023 | 4 |
| 2024 | 3 |
| 2025 | 3 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 15
- Phase 2
- 13
- Phase 3
- 10
- Phase 4
- 18
- No phase
- 14
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 17 · Other 51
Montefiore Medical Center (3) · Johnson & Johnson Consumer and Personal Products Worldwide (3) · Lakehead University (2) · Stanford University (2) · University of Rochester (2) · Dr. Reddy's Laboratories Limited (2) · Tianjin Medical University Cancer Institute and Hospital (2) · University Of Perugia (2)
Often tested with
Tested in the same studies.
Acetaminophen (6) · Cetirizine (4) · Metoclopramide (4) · Melatonin (3) · Trazodone (3) · Gabapentin (3) · Filgrastim (3) · Methylprednisolone (3)
Studies
Open first, then newest update. How each study uses Diphenhydramine is read from its arms, and is right about nine times in ten.
Testing it · 68
- A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for InsomniaRecruitingPhase 4University of PennsylvaniaNCT07542756Written as Diphenhydramine, 25 mg
- Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester AbortionsRecruitingPhase 4University of RochesterNCT07542730Written as Diphenhydramine
- Toripalimab Combined With Platinum-based Chemotherapy With or Without H1 Receptor Antagonist in the Perioperative Treatment of Resectable Non-small Cell Lung CancerNot yet recruitingPhase 2Tianjin Medical University Cancer Institute and HospitalNCT07358689Written as Diphenhydramine
- Anticholinergics for Cervical Edema in LaborRecruitingPhase 2/3The University of Texas Health Science Center, HoustonNCT06702670Written as Treatment with Diphenhydramine
- Trial of Diphenhydramine for Sleep in Children With AutismRecruitingPhase 2Stanford UniversityNCT05501678Written as Diphenhydramine
- Stem Cell Transplantation in Crohn's DiseaseRecruitingPhase 1/2Cedars-Sinai Medical CenterNCT04224558Written as Diphenhydramine
- Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration RepairsRecruitingPhase 3Florida Atlantic UniversityNCT06910241Written as Diphenhydramine
- Histamines and Central HemodynamicsRecruitingNot applicableUniversity of British ColumbiaNCT07285031Written as Diphenhydramine hydrochloride
- Phase III Clinical Study of Cetirizine Hydrochloride Injection in Treatment of Acute UrticariaRecruitingPhase 3Shandong New Time Pharmaceutical Co., LTDNCT06819774Written as Diphenhydramine Hydrochloride Injection
- Study of Tislelizumab and Platinum-based Chemotherapy Combination With H1 Receptor Antagonist（Diphenhydramine）in Advanced and Metastatic Non-Small Cell Lung CancerNot yet recruitingPhase 3Tianjin Medical University Cancer Institute and HospitalNCT06704620Written as Diphenhydramine
- Diphenhydramine in Catheter Related Bladder DiscomfortEnrolling by invitationNot applicableCairo UniversityNCT06345261Written as DiphenhydrAMINE 50 Mg/mL Injectable Solution
- Over-the-Counter Antihistamines & Heat StressRecruitingPhase 4Lakehead UniversityNCT06217367Written as 50 mg Diphenhydramine
- Multi-virus CTLs Expressing CD19 Chimeric Receptors, CD19 Positive Malignancies Post SCT, MULTIPRATActive, not recruitingPhase 1Baylor College of MedicineNCT00840853Written as Benadryl and Tylenol
- Treg Therapy in Subclinical Inflammation in Kidney TransplantationCompletedPhase 1/2National Institute of Allergy and Infectious Diseases (NIAID)NCT02711826Written as Diphenhydramine
- A Study to Evaluate Efficacy, Safety, and Tolerability of Alemtuzumab in Pediatric Patients With RRMS With Disease Activity on Prior DMTTerminatedPhase 3Genzyme, a Sanofi CompanyNCT03368664Written as Diphenydramine
- Chicago Social Drinking ProjectActive, not recruitingNot applicableUniversity of ChicagoNCT00961792Written as Diphenhydramine
- Central Nervous System Effects Following Infusion of Diphenhydramine Using Pharmacokinetic and Pharmacodynamic ModelingTerminatedPhase 4Dent Neuroscience Research CenterNCT05219604Written as DiphenhydrAMINE Injectable Solution
- Prochlorperazine vs Imitrex for Acute Migraine in the Emergency DepartmentWithdrawnNot applicableUnited States Naval Medical Center, PortsmouthNCT00573599Written as prochlorperazine and benadryl IV
- A Safety, Efficacy and Biomarker Study of JNJ-42847922 in Participants With Major Depressive DisorderCompletedPhase 1Janssen-Cilag International NVNCT02476058Written as Diphenhydramine
- Treatment of Nighttime Pruritus in Atopic DermatitisWithdrawnEarly Phase 1University of NebraskaNCT03688464Written as Diphenhydramine
See all 68 studies that test Diphenhydramine →
Given in every arm · 91 — Diphenhydramine is usual care beside what is tested
- A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005)RecruitingPhase 2/3Merck Sharp & Dohme LLCNCT07570173Written as Diphenhydramine
- A Clinical Trial of MK-6255 to Treat Endometrial and Ovarian Cancer (MK-6255-001)Not yet recruitingPhase 1Merck Sharp & Dohme LLCNCT07870278Written as Diphenhydramine
- A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)Not yet recruitingPhase 2Merck Sharp & Dohme LLCNCT07709000Written as Diphenhydramine (or similar antihistamine)
- A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric ParticipantsRecruitingPhase 2Hoffmann-La RocheNCT05039619Written as Diphenhydramine hydrochloride (HCl)
- A Phase II Study of Axicabtagene Ciloleucel, an Anti-CD19 Chimeric Antigen Receptor (CAR) Tcell Therapy, in Combination With Radiotherapy (RT) in Relapsed/Refractory Follicular LymphomaRecruitingPhase 2M.D. Anderson Cancer CenterNCT06043323Written as Diphenhydramine
- A Phase I/II Study of Intraperitoneal Paclitaxel in Patients With Metastatic Appendiceal AdenocarcinomaRecruitingPhase 1/2M.D. Anderson Cancer CenterNCT06207305Written as Diphenhydramine
- A Phase II Study of Perioperative Paclitaxel in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive CytologyRecruitingPhase 2M.D. Anderson Cancer CenterNCT05977998Written as Diphenhydramine
- Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple MyelomaRecruitingPhase 2Benjamin T Diamond, MDNCT05896228Written as Diphenhydramine
- A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple MyelomaRecruitingPhase 2SanofiNCT06356571Written as Diphenhydramine
- Effects of Photobiomodulation (PBM) on Pain After Presentation of Aphthous Ulcers in Pediatric Dental PatientsRecruitingPhase 4The University of Texas Health Science Center, HoustonNCT06819033Written as Maalox plus Benadryl
- Intravenous Fluids in Pediatric MigraineRecruitingNot applicableDayton Children's HospitalNCT06182098Written as Diphenhydramine
- A Phase II Trial of Neoadjuvant Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) With ChemoradiationRecruitingPhase 2Icahn School of Medicine at Mount SinaiNCT04308837Written as Diphenhydramine
- A Phase 2 Study of Isatuximab in Combination With Pomalidomide and Dexamethasone in MM Patients Who Received One Prior Line of Therapy Containing Lenalidomide and a Proteasome InhibitorNot yet recruitingPhase 2Hellenic Society of HematologyNCT05298683Written as Diphenhydramine (or equivalent)
- A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus NephritisActive, not recruitingPhase 3Hoffmann-La RocheNCT04221477Written as Diphenhydramine
- Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell LeukemiaActive, not recruitingPhase 2National Cancer Institute (NCI)NCT01059786Written as Diphenhydramine
- A Study to Evaluate the Efficacy and Safety of Obinutuzumab Versus MMF in Participants With Childhood Onset Idiopathic Nephrotic SyndromeCompletedPhase 3Hoffmann-La RocheNCT05627557Written as Diphenhydramine Hydrochloride
- A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous NephropathyActive, not recruitingPhase 3Hoffmann-La RocheNCT04629248Written as Diphenhydramine
- Effects of Inhibiting Early Inflammation in Kidney Transplant PatientsCompletedPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT02495077Written as Diphenhydramine
- SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMMActive, not recruitingPhase 3SanofiNCT05405166Written as Diphenhydramine
- TReatment for ImmUne Mediated PathopHysiologyActive, not recruitingPhase 2National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT04862221Written as Diphenhydramine
Showing 20 of 91.
As the comparator · 21 — what is tested is compared with Diphenhydramine
- Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot ProjectNot yet recruitingPhase 3University of MiamiNCT07472413Written as Diphenhydramine
- Auricular Acupuncture vs SOC in Migraine HARecruitingNot applicableUniversity of LouisvilleNCT02681211Written as Diphenhydramine 1mg/kg, max 50mg
- Topical Tripelennamine 1% Cream Versus Diphenhydramine 1% Cream for the Relief of Histamine-Induced Itching: A Proof Concept Study in Healthy Adults.CompletedEarly Phase 1Palm Beach Atlantic UniversityNCT07778472Written as Diphenhydramine
- A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple SclerosisCompletedPhase 3Hoffmann-La RocheNCT05232825Written as Diphenhydramine IV
- Psilocybin-facilitated Treatment for Cocaine UseCompletedPhase 2University of Alabama at BirminghamNCT02037126Written as Diphenhydramine
- Safely Stopping Pre-medications in Patients With Breast Cancer Who Are Receiving PaclitaxelCompletedPhase 2/3Ohio State University Comprehensive Cancer CenterNCT04862585Written as Diphenhydramine
- Pilot Phase III Clinical Trial of JDP-205 IV Injection for Treatment of Acute UrticariaCompletedPhase 3JDP Therapeutics, Inc.NCT02023164Written as Diphenhydramine
- A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol DependenceCompletedPhase 2NYU Langone HealthNCT02061293Written as Diphenhydramine
- Using Doxepin for UrticariaStatus unknownPhase 3State University of New York - Upstate Medical UniversityNCT05115136Written as Diphenhydramine
- Feasibility of a Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to PaclitaxelCompletedPhase 3Ciusss de L'Est de l'Île de MontréalNCT04237090Written as Diphenhydramine
- A Study of Lasmiditan on Simulated Driving Performance in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT03459612Written as Diphenhydramine
- Clinical Trial Comparing JDP-205 to Diphenhydramine Injection for the Treatment of Acute UrticariaCompletedPhase 3JDP Therapeutics, Inc.NCT02935699Written as Active Control (Diphenhydramine)
- Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED PatientsCompletedNot applicableLehigh Valley HospitalNCT00641797Written as Diphenhydramine
- "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"CompletedPhase 3Brooke Army Medical CenterNCT03081416Written as Benadryl
- The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus KetamineCompletedPhase 4University Medical Center of Southern NevadaNCT02657031Written as Diphenhydramine
- Droperidol Versus Metoclopramide + Diphenhydramine for the Treatment of Primary HeadachesTerminatedNot applicableUniversity of IowaNCT01406860Written as Metoclopramide + diphenhydramine
- Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to AlfentanilCompletedNot applicableJohns Hopkins UniversityNCT00991809Written as Diphenhydramine
- Compare Pharmacokinetic (PK) Profiles of Naproxen Sodium, Diphenhydramine Hydrochloride, and Naproxen Sodium and Diphenhydramine Hydrochloride CombinationCompletedPhase 1BayerNCT01666678Written as Diphenhydramine HCl
- Simulated Driving Study in Restless Legs SyndromeCompletedPhase 2XenoPort, Inc.NCT01332318Written as Diphenhydramine
- Study to Assess the Effect of Gabapentin Enacarbil on Simulated Driving in Healthy SubjectsCompletedPhase 1XenoPort, Inc.NCT01411124Written as diphenhydramine
Showing 20 of 21.
Codes
What other systems call Diphenhydramine · ClinicalTrials.gg INT007376
- MeSH (NLM) D004155DiphenhydramineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 8GTS82S83MDIPHENHYDRAMINEConfirmed FDA, NLM, Wikidata
- RxNorm 3498Confirmed FDA, Wikidata
- Wikidata Q413486diphenhydramineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C61728DiphenhydramineOne source FDA
- DrugBank DB01075One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D004155 | Diphenhydramine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 8GTS82S83M | DIPHENHYDRAMINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 3498 | — | Confirmed FDA, Wikidata |
| Wikidata | Q413486 | diphenhydramine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C61728 | Diphenhydramine | One source FDA |
| DrugBank | DB01075 | — | One source Wikidata |
Also registered as diphenhydramine citrate (UNII 4OD433S209 · RxNorm 82004) and diphenhydramine hydrochloride (UNII TC2D6JAD40 · RxNorm 1362).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.