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Osteoarthritis, Knee clinical trials

The registry lists 3,292 studies for Osteoarthritis, Knee across more than 10 countries. 621 are recruiting or about to start. 3,054 of them are mainly about Osteoarthritis, Knee (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

ClinicalTrials.gov finds 4,553 studies for Osteoarthritis, Knee. How that becomes 3,290 here

This page counts the studies the registry files under Osteoarthritis, Knee, and those it files under no condition that list Osteoarthritis, Kneethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count

  1. 4,553Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
  2. −40List Osteoarthritis, Knee as a condition, but the registry did not file them under itMost often written as “Bilateral Knee Osteoarthritis” (3), “Osteoarthritis Knees Both” (3), and “Post-Traumatic Osteoarthritis of Knee” (3). The registry filed them under other conditions only, most often Osteoarthritis (35) and Pain (6).
  3. −1,223Match it another way503 name it in the title, 4 in a keyword, and 716 by a synonym or other text the search reads.
  4. 3,290The count on this page59 of them list Osteoarthritis, Knee in their own words; the registry filed them under no condition.

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Status

Completed
1,843
Status unknown
450
Recruiting
382
Not yet recruiting
213
Active, not recruiting
155
Terminated
135

Phase

Phase 2
355
Phase 3
270
Phase 4
229
Phase 1
175
Early Phase 1
26

Where

United States
796
Turkey
268
Canada
170
China
136
Pakistan
134
France
124

Who runs them

Riphah International University (74) · Istituto Ortopedico Rizzoli (31) · Cairo University (26) · Assiut University (22) · Zimmer Biomet (22) · Chinese University of Hong Kong (20) · University of North Carolina, Chapel Hill (19) · Pfizer (17)

What is being tested here

Drugs under test in Osteoarthritis, Knee studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Hyaluronic Acid4618
Duloxetine4416
Cannabidiol408
Platelet rich plasma31042
Triamcinolone3422
Diclofenac328
Metformin314
Triamcinolone Acetonide2418
Tranexamic Acid2214
Dexamethasone2012

Drug classes tested here NSAIDs 6 open · Corticosteroids 5 open · SNRIs 4 open · Local anesthetics 3 open · Antifibrinolytics 2 open

Coming up

45phase 3 studies under way
232studies finish main data collection within a year11 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 382 Osteoarthritis, Knee studies recruiting now, 176 (46%) set no upper age limit and 113 (30%) stop at 75 or younger. 19 (5%) take children under 18. 11 (3%) are for women only and 0 (0%) for men only; 39 (10%) take healthy volunteers.

Recruiting studies that take each age, of 382
AgeWomenMen
1015 (4%)15 (4%)
18145 (38%)144 (38%)
30181 (47%)179 (47%)
40277 (73%)273 (71%)
50356 (93%)347 (91%)
65356 (93%)346 (91%)
75306 (80%)301 (79%)
85219 (57%)215 (56%)

Across all 3,292 studies, recruiting or not: 31% stop at 75 or younger and 11% at 65; 5% take children; 3% are for women only and <1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Osteoarthritis, Knee studies take

Of 101 phase 2 interventional studies under Osteoarthritis, Knee, half reached primary completion within 20 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 120 mo11–44 · 61 studies13 mo9–21 · 34 studies—
Phase 1/225 mo16–47 · 39 studies——
Phase 220 mo12–39 · 101 studies19 mo12–25 · 58 studies30 mo11–61 · 43 studies
Phase 2/331 mo11–43 · 18 studies——
Phase 321 mo15–35 · 100 studies20 mo13–27 · 65 studies32 mo16–50 · 35 studies
Phase 419 mo10–36 · 97 studies—19 mo10–32 · 88 studies
Interventional, no phase18 mo8–36 · 1,251 studies17 mo10–34 · 140 studies18 mo8–36 · 1,111 studies
Observational24 mo14–61 · 220 studies—24 mo12–48 · 179 studies

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 13, 2026.

Started recruiting9

Show 4 more

Results posted2

Stopped1

Newly registered43

Show 38 more

Studies

Recruiting first, then most recently updated. Showing 50 of 3,292. Browse all 3,292 → or search them.