Cough clinical trials
The registry lists 427 studies for Cough across more than 10 countries. 67 are recruiting or about to start. 197 of them are mainly about Cough (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-05. Counting its narrower condition Chronic Cough too: 517 studies, 95 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Hull University Teaching Hospitals NHS Trust (10) · Bellus Health Inc. - a GSK company (8) · Merck Sharp & Dohme LLC (6) · University of Florida (6) · GlaxoSmithKline (6) · Mayo Clinic (5) · McMaster University (5) · Izmir Democracy University (5)
What is being tested here
Drugs under test in Cough studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Duloxetine | 2 | 0 | 2 |
| Amitriptyline | 2 | 0 | 2 |
| Lidocaine | 1 | 5 | 13 |
| BLU-5937 | 1 | 3 | 10 |
| Dexmedetomidine | 1 | 1 | 4 |
| Benzonatate | 1 | 1 | 4 |
| HS-10383 | 1 | 0 | 3 |
| Dexamethasone | 1 | 0 | 2 |
| Pregabalin | 1 | 0 | 2 |
| Magnesium Sulfate | 1 | 1 | 2 |
Drug classes tested here Corticosteroids 3 open · Opioids 2 open · Proton pump inhibitors (PPIs) 1 open · Antihistamines 4 · Bronchodilators 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Suppression After Functional Endoscopic Sinus Surgery · Phase 3 · Assiut University
- May 2027Phase III Trial of Susu Zhike Granules in Children With Cold-cough Syndrome for Acute Cough Treatment · Phase 3 · Tasly Pharmaceutical Group Co., Ltd
- Aug 2027A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China Extension · Phase 3 · GlaxoSmithKline
- Nov 2026Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After Thyroidectomy · Pamukkale University
- Nov 2026Effects of Dexmedetomidine Combined With Lidocaine Topical Administration on Cough Reflex During Extubation in Thyroidectomy Patient. · Sohag University
- Nov 2026Objective Evaluation of Cough Effort in Tracheotomized Patients (LOST Study) · Centre Hospitalier de Saint-Denis
- Nov 2026Mindfulness-Oriented Respiratory Distress Symptom Intervention for Lung Cancer · The Hong Kong Polytechnic University
- Dec 2026Acupressure for Cough in Lung Cancer Survivors · The University of Hong Kong
- Dec 2026Sore Throat After Open Neck Elective Surgery · Saint Petersburg State University, Russia
- Dec 2026Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough · Mayo Clinic
Who these studies take
Of the 46 Cough studies recruiting now, 20 (43%) set no upper age limit and 14 (30%) stop at 75 or younger. 10 (22%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 6 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (15%) | 7 (15%) |
| 18 | 34 (74%) | 34 (74%) |
| 30 | 35 (76%) | 35 (76%) |
| 40 | 38 (83%) | 38 (83%) |
| 50 | 39 (85%) | 39 (85%) |
| 65 | 37 (80%) | 37 (80%) |
| 75 | 34 (74%) | 34 (74%) |
| 85 | 30 (65%) | 30 (65%) |
Across all 427 studies, recruiting or not: 44% stop at 75 or younger and 31% at 65; 22% take children; 2% are for women only and 2% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Cough studies take
Of 21 phase 1 interventional studies under Cough, half reached primary completion within 5 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 5 mo3–12 · 21 studies | — | — |
| Phase 2 | 17 mo10–22 · 21 studies | — | — |
| Phase 3 | 27 mo15–37 · 18 studies | — | — |
| Phase 4 | 13 mo7–33 · 20 studies | — | — |
| Interventional, no phase | 15 mo6–38 · 86 studies | — | 15 mo6–38 · 78 studies |
| Observational | 20 mo14–… · 33 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting2
Studies
Recruiting first, then most recently updated. Showing 50 of 427. Browse all 427 → or search them.
- Physical Impairments in Premature Ventricular ComplexRecruitingNCT073965971 country
- Office-Based Superior Laryngeal Nerve Block for Treatment of Neurogenic CoughRecruitingNCT046423521 country
- Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic CoughRecruitingNCT07566117Not applicable1 country
- Remifentanil Versus Remifentanil-Lidocaine for Tracheal Extubation After ThyroidectomyRecruitingNCT07857356Phase 41 country
- Investigating Novel Strategies in Pediatric Immune Responses and Microbiome Environment: Comprehensive Lung Disease Investigation in Children.Enrolling by invitationNCT067460771 country
- A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic CoughNot yet recruitingNCT07288528Phase 41 country
- Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation TrialNot yet recruitingNCT07736105Not applicable1 country
- Gabapentin vs. Benzonatate vs. Standard of Care for Cough in ILDNot yet recruitingNCT07859839Phase 41 country
- Effects of Video LMA Cuff Pressure in Tympanoplasty.Not yet recruitingNCT078493221 country
- Investigation of Injury Risk and Related Factors in Adolescent Male Soccer PlayersNot yet recruitingNCT078436801 country
- Respiratory Strength Training in Heart Transplant RecipientsRecruitingNCT06190171Not applicable1 country
- Effect Of Intracuff Dexamethasone On Postoperative Sore Throat In Patients Undergoing Laparoscopic CholecystectomyNot yet recruitingNCT07760272Not applicable
- 90% Effective Infusion Time of Sufentanil to Prevent Induction Cough: A Biased Coin Sequential StudyNot yet recruitingNCT07778953Not applicable1 country
- Tracheal Cuff Pressure and Postoperative ComplicationsRecruitingNCT072641791 country
- Dose-Escalation Study of Artesunate Patients With IPFRecruitingNCT05988463Phase 11 country
- Acupressure for Cough in Lung Cancer SurvivorsRecruitingNCT07315672Not applicable2 countries
- Efficacy of Intramuscular Steroid Injection for Chronic Cough.RecruitingNCT06634823Early Phase 11 country
- Oliceridine vs Sufentanil for Cough During Anesthesia InductionRecruitingNCT07660380Phase 41 country
- Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric AcidRecruitingNCT07531901Not applicable1 country
- Prospective Multicentre Study on Symptoms in First-onset Bronchial Asthma in Children and AdolescentsRecruitingNCT062014941 country
- Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic AppendectomyRecruitingNCT07678086Not applicable1 country
- Spinal Stimulation + FES-Assisted Cough Training in SCIEnrolling by invitationNCT07683780Not applicable1 country
- Usefulness and Feasibility of Ultrasound in Office Laryngology ProceduresNot yet recruitingNCT06579989Not applicable1 country
- A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China ExtensionRecruitingNCT07650084Phase 31 country
- Stimulation of the Larynx to Treat Unexplained Chronic CoughRecruitingNCT05273190Not applicable1 country
- Observational Study of SIROPSEDAL in Acute CoughNot yet recruitingNCT076256831 country
- Does the Coaching Function Improve the Learning of Mechanical In-exsufflation (MI-E) in Paediatric Subjects?RecruitingNCT06190431Not applicable1 country
- Breathing With Amyotrophic Lateral SclerosisRecruitingNCT05819931Not applicable1 country
- Improved Child Nutrition and Development Through Social TransfersNot yet recruitingNCT07569172Not applicable1 country
- Epidemiological Study on Community Acquired PneumoniaRecruitingNCT021391631 country
- Evaluation of Treatments for Dry or Productive CoughRecruitingNCT07330856Phase 41 country
- Swiss Paediatric Airway CohortRecruitingNCT035052162 countries
- Sore Throat After Open Neck Elective SurgeryRecruitingNCT07124650Phase 41 country
- Validation of the C-mo System - Cough MonitoringRecruitingNCT05989698Not applicable1 country
- Airway Microbiome of Patients With Protracted Bacterial BronchitisRecruitingNCT072554301 country
- Focused Echocardiography for Primary Care PhysiciansNot yet recruitingNCT07427303Not applicable
- Efficacy and Safety of Rengalin in the Treatment of ARVI Cough in ChildrenRecruitingNCT07171099Phase 31 country
- Combined Acupressure Effects on Post-Thoracotomy Pain and Lung VolumeRecruitingNCT07411417Not applicable1 country
- Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related CoughRecruitingNCT05120934Phase 21 country
- Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic CoughRecruitingNCT05110144Phase 21 country
- Endotracheal Tube Suctioning Versus No Suctioning During Emergence From General AnesthesiaRecruitingNCT07287293Not applicable1 country
- Monitoring Coughs for the Early Detection of Worsening COPDRecruitingNCT072124391 country
- Treating People With Idiopathic Pulmonary Fibrosis With the Addition of LansoprazoleRecruitingNCT04965298Phase 31 country
- Prospective Clinical Study on the Clinical Efficacy and Prognostic Outcome of ICS/LABA Combined With Liqin Zhike Formula in the Treatment of Cough Variant AsthmaNot yet recruitingNCT07272278Not applicable
- Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Suppression After Functional Endoscopic Sinus SurgeryNot yet recruitingNCT07213037Phase 3
- Efficiency of the "Medidux" Smartphone App for Demission Management in Patients Medicated in Acute Admission Unit (AAU)RecruitingNCT06655337Not applicable1 country
- Efficacy and Safety of AG2001 in Patients With Acute BronchitisNot yet recruitingNCT07198347Phase 3
- Longitudinal Phenotyping and Endotyping Study in Adult Patients With Mild, Moderate, or Severe AsthmaRecruitingNCT071898061 country
- Validation of a Questionnaire to Measure Cough SeverityRecruitingNCT066698971 country
- Cough Management Wellness App for Refractory or Unexplained Chronic CoughRecruitingNCT07070895Not applicable1 country