Emergence Delirium clinical trials
The registry lists 752 studies for Emergence Delirium across more than 10 countries. 262 are recruiting or about to start. 604 of them are mainly about Emergence Delirium (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
ClinicalTrials.gov finds 798 studies for Emergence Delirium. How that becomes 749 here
This page counts the studies the registry files under Emergence Delirium, and those it files under no condition that list Emergence Deliriumthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 798Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −4List Emergence Delirium as a condition, but the registry did not file them under itMost often written as “Emergence Delirium in Pediatric Anesthesia” (2), “Pediatric Emergence Agitation and Pain” (1), and “Post Tonsillectomy Emergence Agitation” (1). The registry filed them under other conditions only, most often Pain (1) and Pain, Postoperative (1).
- −48Match it another way46 name it in the title and 2 by a synonym or other text the search reads.
- 746Counted here and found by its search5 of them list Emergence Delirium in their own words; the registry filed them under no condition.
- +3
Counted here, but its search does not find them
- 749The count on this page
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Status
Who runs them
Assiut University (14) · Chinese PLA General Hospital (14) · Charite University, Berlin, Germany (13) · RenJi Hospital (12) · Peking University First Hospital (11) · Ain Shams University (10) · Beijing Tiantan Hospital (10) · Tanta University (10)
What is being tested here
Drugs under test in Emergence Delirium studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexmedetomidine | 30 | 13 | 80 |
| Propofol | 9 | 0 | 24 |
| Remimazolam | 9 | 0 | 13 |
| Ketamine | 6 | 0 | 15 |
| Lidocaine | 6 | 2 | 8 |
| Esketamine | 5 | 0 | 8 |
| Sevoflurane | 4 | 1 | 15 |
| Midazolam | 3 | 2 | 10 |
| Melatonin | 3 | 2 | 6 |
| Acetaminophen | 3 | 1 | 6 |
Drug classes tested here Local anesthetics 10 open · Inhaled anesthetics 6 open · Opioids 3 open · Cholinesterase inhibitors 1 open · NSAIDs 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium · Phase 3 · Mayo Clinic
- Dec 2026Ketofol Versus Ketodex for POD Prophylaxis in Elderly Cancer Surgery · Phase 3 · Cairo University
- Dec 2026Lactium Premedication to Prevent Emergence Agitation · Phase 3 · Tanta University
- Dec 2026Oral Versus Intravenous Magnesium on Emergence Delirium · Phase 3 · Tanta University
- Dec 2026MInimizing Delirium With Nasal Dexmedetomidine-InducEd Sleep (MIDDIES) · Phase 3 · Sixth Affiliated Hospital, Sun Yat-sen University
- Mar 2027MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children · Phase 3 · Arash Afshari
- Mar 2027Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery · Phase 3 · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
- Jun 2027Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery · Phase 3 · RenJi Hospital
- Oct 2027Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery · Phase 3 · Assiut University
- Nov 2027Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy · Phase 3 · Assiut University
Who these studies take
Of the 143 Emergence Delirium studies recruiting now, 79 (55%) set no upper age limit and 44 (31%) stop at 75 or younger. 34 (24%) take children under 18. 2 (1%) are for women only and 0 (0%) for men only; 24 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 13 (9%) | 13 (9%) |
| 18 | 42 (29%) | 42 (29%) |
| 30 | 44 (31%) | 44 (31%) |
| 40 | 44 (31%) | 44 (31%) |
| 50 | 45 (31%) | 45 (31%) |
| 65 | 103 (72%) | 102 (71%) |
| 75 | 99 (69%) | 98 (69%) |
| 85 | 96 (67%) | 96 (67%) |
Across all 752 studies, recruiting or not: 36% stop at 75 or younger and 33% at 65; 28% take children; <1% are for women only and 1% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Emergence Delirium studies take
Of 50 phase 4 interventional studies under Emergence Delirium, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 4 | 19 mo11–33 · 50 studies | — | 19 mo11–33 · 50 studies |
| Interventional, no phase | 19 mo7–36 · 186 studies | — | 19 mo7–36 · 186 studies |
| Observational | 21 mo10–43 · 180 studies | — | 21 mo10–43 · 180 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting5
- Prediction and Prevention of Postoperative Mortality and MorbidityNov 12, 2026NCT06042413
- Lactium Premedication to Prevent Emergence AgitationNov 5, 2026NCT07894484
- Remimazolam for Reducing Postoperative Delirium in Elderly Patients Undergoing Laparoscopic GastrectomyNov 4, 2026NCT07351474
- Acetaminophen-Mannitol Injection and Postoperative DeliriumOct 29, 2026NCT07235995
- Postoperative Delirium and Analgesia in Elderly PatientsOct 28, 2026NCT07849517
Newly registered19
- Prehab-COG: Does Preoperative Exercise Improve Postoperative Cognitive Outcomes?Nov 12, 2026NCT07933003
- Modified Surgical APGAR Score for Predicting Postoperative Delirium in Emergency SurgeryNov 10, 2026NCT07929142
- Cerebral Monitoring and Postoperative Delirium in Pediatric Cardiac SurgeryNov 9, 2026NCT07923942
- The Impact of Fast-Track Anesthesia on Postoperative Neurocognitive Function in Patients Undergoing Cardiac SurgeryNov 6, 2026NCT07923344
- Intracuff Dexmedetomidine Versus Alkalinized Lidocaine for Peri-Extubation Cough and Hemodynamic Responses in Elderly PatientsNov 4, 2026NCT07916246
Show 14 moreShow fewer
- Comparison of IV Dexmedetomidine Versus Clonidine Versus no Alpha 2 Agonist on Emergency Delirium, PACU Length of Stay and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: a Prospective Observational StudyNov 3, 2026NCT07913308
- Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Sphenopalatine Ganglion Block for Functional Endoscopic Sinus SurgeryNov 2, 2026NCT07911202
- Low Pneumoperitoneum Pressure for Delirium Prevention in Elderly LaparoscopyOct 30, 2026NCT07906444
- The Effect of Remimazolam Tosylate on the Incidence of Postoperative Delirium in Older Patients Undergoing Cardiac Surgery: A Prospective Randomized Controlled TrialOct 30, 2026NCT07908121
- Sugammadex Timing and Recovery Profile in Pediatric AdenotonsillectomyOct 28, 2026NCT07902193
- Lactium Premedication to Prevent Emergence AgitationOct 26, 2026NCT07894484
- Liposomal Bupivacaine Fascia Iliaca Block for Perioperative Sleep Quality in Elderly Patients With Intertrochanteric FractureOct 23, 2026NCT07892859
- A Prospective Comparative Clinical Trial of Postoperative Delirium Incidence in Open Versus Laparoscopic NephrectomyOct 23, 2026NCT07892898
- Mechanisms and Intervention Strategies of Perioperative Glycemic Variability on Postoperative DeliriumOct 23, 2026NCT07893353
- Intranasal Dexmedetomidine Combined With Esketamine for Emergence Quality After Suspension LaryngoscopyOct 19, 2026NCT07880938
- Immunonutrition and Neuromonitoring for Postoperative Delirium in Gynecologic OncologyOct 16, 2026NCT07877285
- Effects of Music on Preoperative Anxiety and Emergence Delirium in ChildrenOct 16, 2026NCT07877428
- BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung MachineOct 14, 2026NCT07872982
- Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing TonsillectomyOct 13, 2026NCT07871266
Studies
Recruiting first, then most recently updated. Showing 50 of 752. Browse all 752 → or search them.
- Prediction and Prevention of Postoperative Mortality and MorbidityRecruitingNCT06042413Not applicable1 country
- Prehab-COG: Does Preoperative Exercise Improve Postoperative Cognitive Outcomes?Not yet recruitingNCT07933003Not applicable1 country
- Cerebral Oximetry During Awake Carotid EndarterectomyNot yet recruitingNCT078160811 country
- Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Sphenopalatine Ganglion Block for Functional Endoscopic Sinus SurgeryNot yet recruitingNCT07911202Phase 41 country
- Impact of Neuromonitoring on Postoperative Agitation in Pediatric General AnesthesiaRecruitingNCT07243990Not applicable1 country
- The Impact of Fast-Track Anesthesia on Postoperative Neurocognitive Function in Patients Undergoing Cardiac SurgeryRecruitingNCT079233441 country
- Lactium Premedication to Prevent Emergence AgitationRecruitingNCT07894484Phase 31 country
- Intracuff Dexmedetomidine Versus Alkalinized Lidocaine for Peri-Extubation Cough and Hemodynamic Responses in Elderly PatientsNot yet recruitingNCT07916246Not applicable1 country
- Remimazolam for Reducing Postoperative Delirium in Elderly Patients Undergoing Laparoscopic GastrectomyRecruitingNCT07351474Not applicable1 country
- Comparison of IV Dexmedetomidine Versus Clonidine Versus no Alpha 2 Agonist on Emergency Delirium, PACU Length of Stay and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: a Prospective Observational StudyNot yet recruitingNCT079133081 country
- The Effect of Remimazolam Tosylate on the Incidence of Postoperative Delirium in Older Patients Undergoing Cardiac Surgery: A Prospective Randomized Controlled TrialRecruitingNCT07908121Not applicable1 country
- Low Pneumoperitoneum Pressure for Delirium Prevention in Elderly LaparoscopyRecruitingNCT07906444Not applicable1 country
- Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch SurgeryNot yet recruitingNCT07816068Phase 41 country
- Acetaminophen-Mannitol Injection and Postoperative DeliriumRecruitingNCT07235995Phase 41 country
- Postoperative Delirium and Analgesia in Elderly PatientsRecruitingNCT07849517Not applicable1 country
- Sugammadex Timing and Recovery Profile in Pediatric AdenotonsillectomyNot yet recruitingNCT079021931 country
- Creatine and Perioperative Brain HealthNot yet recruitingNCT07310043Not applicable
- Mechanisms and Intervention Strategies of Perioperative Glycemic Variability on Postoperative DeliriumRecruitingNCT07893353Not applicable1 country
- Prospective Observational Multimodal Neuromonitoring During High-Risk Adult SurgeryNot yet recruitingNCT075777261 country
- Intranasal Dexmedetomidine Combined With Esketamine for Emergence Quality After Suspension LaryngoscopyNot yet recruitingNCT07880938Not applicable1 country
- Post Operative Cognitive Dysfunction After Oncologic SurgeryRecruitingNCT037744201 country
- Immunonutrition and Neuromonitoring for Postoperative Delirium in Gynecologic OncologyRecruitingNCT078772851 country
- BrainProtect-guided, Real-time Cerebral Autoregulation Monitoring and Protection of Brain During Cardiac Surgery With Cardiopulmonary Bypass Requiring Heart-lung MachineNot yet recruitingNCT07872982Not applicable4 countries
- Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing TonsillectomyNot yet recruitingNCT07871266Phase 3
- Intravenous Dexmedetomidine as an Adjuvant to Locoregional Anesthesia in Pediatric SurgeryRecruitingNCT06736483Phase 21 country
- Total Intravenous Versus Inhalational Anesthesia in Patients Undergoing Hip Fracture SurgeryRecruitingNCT078609961 country
- Dexmedetomidine for Prevention of Delirium After Hip Fracture SurgeryRecruitingNCT078678991 country
- BIS in ICU Interventional StudyNot yet recruitingNCT07350122Not applicable
- Remifentanil vs Fentanyl in Children 7-12 After Urologic Surgery: Emergence Delirium and Recovery QualityNot yet recruitingNCT07800845Phase 41 country
- Perioperative Biomarkers and Postoperative Delirium in Older Adults Undergoing Abdominal Cancer SurgeryRecruitingNCT078594881 country
- Transcranial Doppler and Artificial Intelligence Prediction of Postoperative Delirium in Heart Valve SurgeryNot yet recruitingNCT078585781 country
- Effects of PNB Timing on Postoperative Delirium for Hip FractureNot yet recruitingNCT078561081 country
- Music Intervention to Reduce Anxiety and Prevent Delirium in Older Adults Undergoing Cardiac SurgeryNot yet recruitingNCT07851194Not applicable1 country
- CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm StateRecruitingNCT061338421 country
- Dexmedetomidine and Agitation After Nasal SurgeryRecruitingNCT06867302Not applicable1 country
- Effect of Preoperative Ultrasound-Guided Stellate Ganglion Block on Postoperative Delirium in Older Adults Undergoing Elective Peripheral Endovascular InterventionNot yet recruitingNCT07848113Not applicable
- Heart Rate Variability Changes and Postoperative Delirium After Major Abdominal SurgeryRecruitingNCT077834641 country
- Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance ImagingRecruitingNCT07369128Phase 41 country
- Sleep and Circadian Rhythm Biomarkers of Postoperative DeliriumRecruitingNCT060523971 country
- Digital Sleep Optimization for Brain Health Outcomes in Older Surgical PatientsRecruitingNCT06375265Not applicable1 country
- The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older AdultsRecruitingNCT074241701 country
- Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture SurgeryNot yet recruitingNCT07810556Phase 2/3
- Eye Movements to Predict Post-Operative DeliriumEnrolling by invitationNCT078064871 country
- Comparing the Efficacy of Propofol and Dexmedetomidine in Prevention of Emergence Agitation After Sevoflurane Anesthesia in ChildrenRecruitingNCT07799311Phase 41 country
- Ciprofol, Propofol and Sevoflurane for Postoperative Delirium in Elderly Brain Tumor PatientsNot yet recruitingNCT07799623Not applicable1 country
- Selective Antegrade Cerebral Perfusion and Perioperative Optic Nerve Sheath Diameter in Ascending Aortic SurgeryNot yet recruitingNCT07800806Not applicable1 country
- Evaluation of a Hospital Program to Prevent Postoperative Delirium in Older PatientsNot yet recruitingNCT07787832Not applicable
- Maintaining Intraoperative Mean Arterial Pressure at 85 mmHg or Higher to Reduce Postoperative Delirium in Older Patients With Arterial Hypertension Having Non-cardiac SurgeryRecruitingNCT07713121Not applicable1 country
- The Impact of Left Stellate Ganglion Block on Systemic Inflammation and Neuromodulation in CABG Surgery.Not yet recruitingNCT07776496Not applicable
- Emergence Delirium、fBFI-ENO Score (Extraversion + Neuroticism - Openness) Based on the Fast Big Five Personality Scale-10、An Adult Patient With ASAI-III Who is Scheduled for Elective Non-cardiac Surgery and is to Undergo General Anesthesia With Tracheal IntubationNot yet recruitingNCT07775768